A Ferro-Heme Protein Senses Oxygen Levels, Which Modulate the Glucagon-Dependent Activation of the Phosphoenolpyruvate Carboxykinase Gene in Rat Hepatocyte Cultures

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1993.2115 ◽

1993 ◽

Vol 195 (2) ◽

pp. 792-798 ◽

Author(s):

T. Kietzmann ◽

H. Schmidt ◽

K. Unthanfechner ◽

I. Probst ◽

K. Jungermann

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Heme Protein ◽

Rat Hepatocyte ◽

Oxygen Levels ◽

Hepatocyte Cultures ◽

Phosphoenolpyruvate Carboxykinase Gene

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Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures Evidence for a heme protein as oxygen sensor

FEBS Letters ◽

10.1016/0014-5793(92)81113-z ◽

1992 ◽

Vol 311 (3) ◽

pp. 251-255 ◽

Author(s):

Thomas Kietzmann ◽

Helga Schmidt ◽

Irmelin Probst ◽

Kurt Jungermann

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Oxygen Sensor ◽

Heme Protein ◽

Rat Hepatocyte ◽

Hepatocyte Cultures ◽

Phosphoenolpyruvate Carboxykinase Gene

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Oxygen sensed via a ferro-heme protein modulates the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene in rat hepatocyte cultures

10.1016/0270-9139(93)92190-b ◽

1993 ◽

Vol 18 (4) ◽

pp. A165

Author(s):

T KIETZMANN

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Heme Protein ◽

Rat Hepatocyte ◽

Hepatocyte Cultures

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Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1991.tb16061.x ◽

1991 ◽

Vol 198 (3) ◽

pp. 635-639 ◽

Author(s):

Josef HELLKAMP ◽

Bruno CHRIST ◽

Helge BASTIAN ◽

Kurt JUNGERMANN

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Rat Hepatocyte ◽

Hepatocyte Cultures ◽

Phosphoenolpyruvate Carboxykinase Gene

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Modulation of the Glucagon-dependent Induction of Phosphoenolpyruvate Carboxykinase by Adenosine, but not Ketone Bodies or Animonia in Rat Hepatocyte Cultures. Possible significance for the zonal heterogeneity of liver parenchyma

Biological Chemistry Hoppe-Seyler ◽

10.1515/bchm3.1987.368.2.1579 ◽

1987 ◽

Vol 368 (2) ◽

pp. 1579-1588 ◽

Author(s):

Bruno CHRIST ◽

Rudolf LÖHNE ◽

Helga SCHMIDT ◽

Kurt JUNGERMANN

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Ketone Bodies ◽

Liver Parenchyma ◽

Rat Hepatocyte ◽

Hepatocyte Cultures

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Oxygen regulates the expression of aldolase A, glyceraldehyde-3-phosphate dehydrogynase and the glucagon-dependent induction of the phosphoenolpyruvate carboxykinase gene via a heme protein mediated mechanism in hepatocytes Institut f�r Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D-37073 G�ttingen, Germany

10.1016/0270-9139(95)94922-4 ◽

1995 ◽

Vol 22 (4) ◽

pp. A300

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Heme Protein ◽

Phosphoenolpyruvate Carboxykinase Gene

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Basal and insulin-stimulated phosphoenolpyruvate carboxykinase (PCK) mRNA degradation is not modulated by oxygen in contrast to it's glucagon-dependent induction in primary rat hepatocyte cultures

10.1016/0270-9139(94)90494-4 ◽

1994 ◽

Vol 19 (4) ◽

pp. I81

Author(s):

T Kietzmann

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Mrna Degradation ◽

Rat Hepatocyte ◽

Hepatocyte Cultures

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Oxygen modulates the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in the first 277 bp of its promoter by sequences different from the CRE via a heme protein-mediated mechanism in hepatocytes Institut f�r Biochemie und Molekulare Zellbiologie, Humboldtallee 23, D-37073 G�ttingen, Germany

10.1016/0270-9139(95)94920-8 ◽

1995 ◽

Vol 22 (4) ◽

pp. A299

Keyword(s):

Phosphoenolpyruvate Carboxykinase ◽

Heme Protein ◽

Phosphoenolpyruvate Carboxykinase Gene

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Induction of phosphoenolpyruvate carboxykinase gene expression by retinoic acid in an adult rat hepatocyte line

Biochemistry ◽

10.1021/bi00501a004 ◽

1990 ◽

Vol 29 (49) ◽

pp. 10883-10888 ◽

Author(s):

Chi Jiunn Pan ◽

Wolfgang Hoeppner ◽

Janice Yang Chou

Keyword(s):

Gene Expression ◽

Retinoic Acid ◽

Phosphoenolpyruvate Carboxykinase ◽

Rat Hepatocyte ◽

Adult Rat ◽

Phosphoenolpyruvate Carboxykinase Gene

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Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and the glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2

FEBS Letters ◽

10.1016/0014-5793(96)00557-1 ◽

1996 ◽

Vol 388 (2-3) ◽

pp. 228-232 ◽

Author(s):

Thomas Kietzmann ◽

Stefanie Freimann ◽

Jutta Bratke ◽

Kurt Jungermann

Keyword(s):

Gene Expression ◽

Hydrogen Peroxide ◽

Phosphoenolpyruvate Carboxykinase ◽

Rat Hepatocyte ◽

Hepatocyte Cultures ◽

Glycolytic Aldolase ◽

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Toxicological properties of thymoquinone in primary rat hepatocyte cultures

Planta Medica ◽

10.1055/s-0028-1084326 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

M Khader ◽

N Bresgen ◽

P Eckl

Keyword(s):

Rat Hepatocyte ◽

Hepatocyte Cultures

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