Mutations on the Hinge Region of Leukocyte Elastase Inhibitor Determine the Loss of Inhibitory Function

2000 ◽  
Vol 274 (3) ◽  
pp. 841-844 ◽  
Author(s):  
Paolo Perani ◽  
Samia Zeggai ◽  
Alicia Torriglia ◽  
Yves Courtois
Keyword(s):  
Hinge Region ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Inhibitory Function

Leukocyte Elastase Inhibitor

2009 ◽  
Vol 1171 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Chloé Leprêtre ◽  
Giuseppina Sidoli ◽  
A. Ivana Scovassi ◽  
Alicia Torriglia
Keyword(s):  
Leukocyte Elastase ◽  
Elastase Inhibitor

scholarly journals The hidden side of SERPINB1/Leukocyte Elastase Inhibitor

2017 ◽  
Vol 62 ◽  
pp. 178-186 ◽  
Author(s):  
Alicia Torriglia ◽  
Elisabeth Martin ◽  
Imene Jaadane
Keyword(s):  
Leukocyte Elastase ◽  
Elastase Inhibitor

scholarly journals Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 392
Author(s):  
Candela Castillo-Felipe ◽  
Lorena Franco-Martínez ◽  
Asta Tvarijonaviciute ◽  
Pia Lopez-Jornet ◽  
Elsa Lamy
Keyword(s):  
Sleep Disturbances ◽  
Relevant Information ◽  
Burning Mouth Syndrome ◽  
Diagnostic Tools ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Number Of Factors ◽  
Whole Saliva ◽  
Burning Mouth ◽  
As Stress

Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosis.

Repurposing a leukocyte elastase inhibitor for neuropathic pain

2015 ◽  
Vol 21 (5) ◽  
pp. 429-430 ◽  
Author(s):  
Andy D Weyer ◽  
Cheryl L Stucky
Keyword(s):  
Neuropathic Pain ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor
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