Role of c-Fyn in FGF-2-Mediated Tube-like Structure Formation by Murine Brain Capillary Endothelial Cells

2002 ◽  
Vol 290 (4) ◽  
pp. 1354-1360 ◽  
Author(s):  
Satoshi Tsuda ◽  
Akira Ohtsuru ◽  
Shunichi Yamashita ◽  
Hiroshi Kanetake ◽  
Shigeru Kanda
Keyword(s):  
Endothelial Cells ◽  
Structure Formation ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells ◽  
Murine Brain

Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells

2010 ◽  
Vol 339 (1-2) ◽  
pp. 201-213 ◽  
Author(s):  
Shimon Lecht ◽  
Hadar Arien-Zakay ◽  
Martin Kohan ◽  
Peter I. Lelkes ◽  
Philip Lazarovici
Keyword(s):  
Endothelial Cells ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells ◽  
Murine Brain

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

2015 ◽  
Vol 1594 ◽  
pp. 15-26 ◽  
Author(s):  
Pietra Candela ◽  
Julien Saint-Pol ◽  
Mélanie Kuntz ◽  
Marie-Christine Boucau ◽  
Yordenca Lamartiniere ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cellular Level ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Brain Pericytes ◽  
Capillary Endothelial Cells

scholarly journals Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn

2002 ◽  
Vol 115 (1) ◽  
pp. 175-183 ◽  
Author(s):  
Yasushi Mochizuki ◽  
Takao Nakamura ◽  
Hiroshi Kanetake ◽  
Shigeru Kanda
Keyword(s):  
Endothelial Cells ◽  
Structure Formation ◽  
Cellular Responses ◽  
Tube Formation ◽  
Brain Capillary ◽  
Downstream Signaling ◽  
Capillary Endothelial Cells ◽  
Murine Brain ◽  
Phosphoinositide 3 Kinase ◽  
Angiopoietin 2

The angiopoietin (Ang)/Tie2 system is exclusively involved in vasculogenesis and angiogenesis. Ang2 is known to inhibit Ang1-mediated phosphorylation of Tie2 as well as cellular responses during embryonic development. Recent studies have demonstrated that Ang2 has angiogenic activities in adult tissues and cultured endothelial cells. In the present study, we examined the downstream signaling pathways involved in Ang2-mediated cellular responses by murine brain capillary cell line, IBE cells. Tie2 was tyrosine phoshorylated by Ang2. Ang2 showed no effect on proliferation, but stimulated chemotaxis and tube-like structure formation. Phosphoinositide 3-kinase (PI 3-kinase) was activated by Ang2 through c-Fes and was involved in chemotaxis toward Ang2. Ang2 also activated c-Fyn in IBE cells. Cells expressing kinase-inactive c-Fyn attenuated Ang2-induced tube formation, suggesting that c-Fyn was responsible for Ang-2-mediated tube formation. Collecting these data, Ang2 activates c-Fes and c-Fyn, leading to migration and tube formation by murine capillary endothelial cells.

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