Transplantation of Clonal Neural Precursor Cells Derived from Adult Human Brain Establishes Functional Peripheral Myelin in the Rat Spinal Cord

2001 ◽  
Vol 167 (1) ◽  
pp. 27-39 ◽  
Author(s):  
Yukinori Akiyama ◽  
Osamu Honmou ◽  
Takaaki Kato ◽  
Teiji Uede ◽  
Kazuo Hashi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Human Brain ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord ◽  
Adult Human Brain ◽  
Adult Human

Adult human spinal cord harbors neural precursor cells that generate neurons and glial cells in vitro

2008 ◽  
Vol 86 (9) ◽  
pp. 1916-1926 ◽  
Author(s):  
C. Dromard ◽  
H. Guillon ◽  
V. Rigau ◽  
C. Ripoll ◽  
J.C. Sabourin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glial Cells ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Human Spinal Cord ◽  
Adult Human

Endogenous stem cell proliferation induced by intravenous hedgehog agonist administration after contusion in the adult rat spinal cord

2009 ◽  
Vol 10 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Nicholas C. Bambakidis ◽  
Eric M. Horn ◽  
Peter Nakaji ◽  
Nicholas Theodore ◽  
Elizabeth Bless ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intravenous Administration ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord ◽  
Adult Rats ◽  
Significant Difference ◽  
Cord Injury

Object Sonic hedgehog (Shh) is a glycoprotein molecule that upregulates the transcription factor Gli1. The Shh protein plays a critical role in the proliferation of endogenous neural precursor cells when directly injected into the spinal cord after a spinal cord injury in adult rodents. Small-molecule agonists of the hedgehog (Hh) pathway were used in an attempt to reproduce these findings through intravenous administration. Methods The expression of Gli1 was measured in rat spinal cord after the intravenous administration of an Hh agonist. Ten adult rats received a moderate contusion and were treated with either an Hh agonist (10 mg/kg, intravenously) or vehicle (5 rodents per group) 1 hour and 4 days after injury. The rats were killed 5 days postinjury. Tissue samples were immediately placed in fixative. Samples were immunohistochemically stained for neural precursor cells, and these cells were counted. Results Systemic dosing with an Hh agonist significantly upregulated Gli1 expression in the spinal cord (p < 0.005). After spinal contusion, animals treated with the Hh agonist had significantly more nestin-positive neural precursor cells around the rim of the lesion cavity than in vehicle-treated controls (means ± SDs, 46.9 ± 12.9 vs 20.9 ± 8.3 cells/hpf, respectively, p < 0.005). There was no significant difference in the area of white matter injury between the groups. Conclusions An intravenous Hh agonist at doses that upregulate spinal cord Gli1 transcription also increases the population of neural precursor cells after spinal cord injury in adult rats. These data support previous findings based on injections of Shh protein directly into the spinal cord.

Electrophysiological Properties of Mitogen-Expanded Adult Rat Spinal Cord and Subventricular Zone Neural Precursor Cells

1999 ◽  
Vol 158 (1) ◽  
pp. 143-154 ◽  
Author(s):  
Rong-Huan Liu ◽  
Dante J. Morassutti ◽  
Scott R. Whittemore ◽  
Jeffrey S. Sosnowski ◽  
David S.K. Magnuson
Keyword(s):  
Spinal Cord ◽  
Subventricular Zone ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord ◽  
Electrophysiological Properties ◽  
Adult Rat ◽  
Adult Rat Spinal Cord

Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cord

2009 ◽  
Vol 1278 ◽  
pp. 15-26 ◽  
Author(s):  
Mia Emgård ◽  
Lena Holmberg ◽  
Eva-Britt Samuelsson ◽  
Ben A. Bahr ◽  
Scott Falci ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord

Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury

2021 ◽  
Vol 568 ◽  
pp. 103-109
Author(s):  
Xue Chen ◽  
Xin-Yao Yin ◽  
Ya-Yu Zhao ◽  
Chen-Chun Wang ◽  
Pan Du ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
The Novel ◽  
Cord Injury ◽  
Seed Cells ◽  
Muse Cells

scholarly journals Spinal cord-derived neural precursor cells as a preventive therapy for spinal cord injury

2018 ◽  
Vol 13 (4) ◽  
pp. 1101
Author(s):  
SeyedMojtaba Hosseini ◽  
Ali Sharafkhah ◽  
SeyyedMohyeddin Ziaee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Preventive Therapy ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cord Injury

scholarly journals EPO-releasing neural precursor cells promote axonal regeneration and recovery of function in spinal cord traumatic injury

2017 ◽  
Vol 35 (6) ◽  
pp. 583-599 ◽  
Author(s):  
S. Carelli ◽  
T. Giallongo ◽  
Z. Gombalova ◽  
D. Merli ◽  
A.M. Di Giulio ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Axonal Regeneration ◽  
Recovery Of Function ◽  
Traumatic Injury ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

Region-specific growth properties and trophic requirements of brain- and spinal cord-derived rat embryonic neural precursor cells

Neuroscience ◽  
2005 ◽  
Vol 135 (3) ◽  
pp. 851-862 ◽  
Author(s):  
S.-L. Fu ◽  
Z.-W. Ma ◽  
L. Yin ◽  
C. Iannotti ◽  
P.-H. Lu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Specific Growth ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Growth Properties ◽  
Brain And Spinal Cord
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