Region-specific growth properties and trophic requirements of brain- and spinal cord-derived rat embryonic neural precursor cells

Neuroscience ◽  
2005 ◽  
Vol 135 (3) ◽  
pp. 851-862 ◽  
Author(s):  
S.-L. Fu ◽  
Z.-W. Ma ◽  
L. Yin ◽  
C. Iannotti ◽  
P.-H. Lu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Specific Growth ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Growth Properties ◽  
Brain And Spinal Cord

Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury

2021 ◽  
Vol 568 ◽  
pp. 103-109
Author(s):  
Xue Chen ◽  
Xin-Yao Yin ◽  
Ya-Yu Zhao ◽  
Chen-Chun Wang ◽  
Pan Du ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
The Novel ◽  
Cord Injury ◽  
Seed Cells ◽  
Muse Cells

scholarly journals Spinal cord-derived neural precursor cells as a preventive therapy for spinal cord injury

2018 ◽  
Vol 13 (4) ◽  
pp. 1101
Author(s):  
SeyedMojtaba Hosseini ◽  
Ali Sharafkhah ◽  
SeyyedMohyeddin Ziaee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Preventive Therapy ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Cord Injury

scholarly journals EPO-releasing neural precursor cells promote axonal regeneration and recovery of function in spinal cord traumatic injury

2017 ◽  
Vol 35 (6) ◽  
pp. 583-599 ◽  
Author(s):  
S. Carelli ◽  
T. Giallongo ◽  
Z. Gombalova ◽  
D. Merli ◽  
A.M. Di Giulio ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Axonal Regeneration ◽  
Recovery Of Function ◽  
Traumatic Injury ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

Adult human spinal cord harbors neural precursor cells that generate neurons and glial cells in vitro

2008 ◽  
Vol 86 (9) ◽  
pp. 1916-1926 ◽  
Author(s):  
C. Dromard ◽  
H. Guillon ◽  
V. Rigau ◽  
C. Ripoll ◽  
J.C. Sabourin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glial Cells ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Human Spinal Cord ◽  
Adult Human

scholarly journals Analysis of Gene Expression in Mouse Spinal Cord-derived Neural Precursor Cells During Neuronal Differentiation

2009 ◽  
Vol 7 (2) ◽  
pp. 85-96
Author(s):  
Joon-Ik Ahn ◽  
So-Young Kim ◽  
Moon-Jeong Ko ◽  
Hye-Joo Chung ◽  
Ho-Sang Jeong
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Neuronal Differentiation ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Mouse Spinal Cord

Endogenous stem cell proliferation induced by intravenous hedgehog agonist administration after contusion in the adult rat spinal cord

2009 ◽  
Vol 10 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Nicholas C. Bambakidis ◽  
Eric M. Horn ◽  
Peter Nakaji ◽  
Nicholas Theodore ◽  
Elizabeth Bless ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intravenous Administration ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord ◽  
Adult Rats ◽  
Significant Difference ◽  
Cord Injury

Object Sonic hedgehog (Shh) is a glycoprotein molecule that upregulates the transcription factor Gli1. The Shh protein plays a critical role in the proliferation of endogenous neural precursor cells when directly injected into the spinal cord after a spinal cord injury in adult rodents. Small-molecule agonists of the hedgehog (Hh) pathway were used in an attempt to reproduce these findings through intravenous administration. Methods The expression of Gli1 was measured in rat spinal cord after the intravenous administration of an Hh agonist. Ten adult rats received a moderate contusion and were treated with either an Hh agonist (10 mg/kg, intravenously) or vehicle (5 rodents per group) 1 hour and 4 days after injury. The rats were killed 5 days postinjury. Tissue samples were immediately placed in fixative. Samples were immunohistochemically stained for neural precursor cells, and these cells were counted. Results Systemic dosing with an Hh agonist significantly upregulated Gli1 expression in the spinal cord (p < 0.005). After spinal contusion, animals treated with the Hh agonist had significantly more nestin-positive neural precursor cells around the rim of the lesion cavity than in vehicle-treated controls (means ± SDs, 46.9 ± 12.9 vs 20.9 ± 8.3 cells/hpf, respectively, p < 0.005). There was no significant difference in the area of white matter injury between the groups. Conclusions An intravenous Hh agonist at doses that upregulate spinal cord Gli1 transcription also increases the population of neural precursor cells after spinal cord injury in adult rats. These data support previous findings based on injections of Shh protein directly into the spinal cord.

Transplantation of Bone Marrow Stromal Cell-Derived Neural Precursor Cells Ameliorates Deficits in a Rat Model of Complete Spinal Cord Transection

2013 ◽  
Vol 22 (9) ◽  
pp. 1613-1625 ◽  
Author(s):  
Misaki Aizawa-Kohama ◽  
Toshiki Endo ◽  
Masaaki Kitada ◽  
Shohei Wakao ◽  
Akira Sumiyoshi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Rat Model ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Precursor Cells ◽  
Spinal Cord Transection ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Marrow Stromal Cell

Stem cell delivery by lumbar puncture as a therapeutic alternative to direct injection into injured spinal cord

2008 ◽  
Vol 9 (4) ◽  
pp. 390-399 ◽  
Author(s):  
Birgit Neuhuber ◽  
Alissa L. Barshinger ◽  
Courtney Paul ◽  
Jed S. Shumsky ◽  
Takahiko Mitsui ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Lumbar Puncture ◽  
Recovery Of Function ◽  
Direct Injection ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Bladder Function ◽  
Neural Precursor ◽  
Cell Delivery ◽  
Injury Site

Object Using cellular transplants to treat spinal cord injury is a promising therapeutic strategy, but transplants grafted directly into the injury site can further damage the already compromised cord. To avoid additional trauma and to simplify translation to the clinic, it is advantageous to use less invasive delivery methods. Methods The authors compared the efficacy of intrathecal cell delivery at the lumbar region (lumbar puncture [LP]) to direct injection into a thoracic contusion injury using a mixed population of lineage-restricted neural precursor cells. Results Direct injection resulted in a higher volume of neural precursor cells located throughout the injury site, whereas fewer LP-delivered cells accumulated at the dorsal aspect of the injured cord. Both grafting methods were neuroprotective, resulting in reduction of injury size and greater tissue sparing compared with controls. Functional recovery was evaluated by assessing motor and bladder function. Animals that received cells via direct injection performed significantly better in the open-field locomotor test than did operated controls, while LP-treated animals showed intermediate recovery of function that did not differ statistically from that of either operated controls or directly injected animals. Bladder function, however, was significantly improved in both directly injected and LP-treated animals. Conclusion Grafting of stem cells via LP resulted in localized accumulation of cells at the injury site, neuroprotection, and modest recovery of function. Further optimization of the LP procedure by increasing the number of cells that are delivered and determining the optimal delivery schedule may further improve recovery to levels comparable to direct injection.

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