A Spontaneous Canine Model of Mucous Membrane (Cicatricial) Pemphigoid, an Autoimmune Blistering Disease Affecting Mucosae and Mucocutaneous Junctions

2001 ◽  
Vol 16 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Thierry Olivry ◽  
Stanley M Dunston ◽  
Marianne Schachter ◽  
Luting Xu ◽  
Ngon Nguyen ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Canine Model ◽  
Cicatricial Pemphigoid ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease

scholarly journals Serum and Salivary BP180 NC 16a Enzyme-Linked Immunosorbent Assay in Mucous Membrane Pemphigoid. Analysis of a Cohort of 25 Patients

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 21
Author(s):  
Vella ◽  
Galleggiante ◽  
Laudadio ◽  
Contaldo ◽  
Stasio ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Immunosorbent Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mucous Membrane Pemphigoid ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease

Mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease, affecting one [...]

scholarly journals Oral Pemphigus Vulgaris: A case report

2020 ◽  
Vol 10 (1) ◽  
pp. 91-93
Author(s):  
Radha Baral ◽  
Bidhata Ojha ◽  
Dipshikha Bajracharya
Keyword(s):  
Case Report ◽  
Mucous Membrane ◽  
Male Patient ◽  
Clinical Examination ◽  
Adhesion Molecule ◽  
Case History ◽  
Pemphigus Vulgaris ◽  
Underlying Mechanism ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease

Pemphigus vulgaris is an autoimmune blistering disease clinically presenting as vesicles, bullae and erosion on the skin and mucous membrane. Histopathologically, it is characterized by acantholy­sis and supra basilar split. The underlying mechanism causing intra epithelial split in pemphigus vulgaris is binding of IgG autoantibodies to desmoglin 3 which belongs to a transmembrane gly­coprotein adhesion molecule. Here we present a case of 27 years old male patient suffering from pemphigus vulgaris. This Case report highlights the importance of detailed case history, thorough clinical examination and appropriate investigation to reach a diagnosis of vesiculobullous lesion.

scholarly journals Comparison of Two Diagnostic Assays for Anti-Laminin 332 Mucous Membrane Pemphigoid

2021 ◽  
Vol 12 ◽  
Author(s):  
Stephanie Goletz ◽  
Federica Giurdanella ◽  
Maike M. Holtsche ◽  
Miranda Nijenhuis ◽  
Barbara Horvath ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Blood Donors ◽  
Pemphigus Vulgaris ◽  
Mucous Membrane Pemphigoid ◽  
Diagnostic Assays ◽  
Autoimmune Blistering Disease ◽  
Highly Sensitive ◽  
Blistering Disease ◽  
Mucosal Lesions ◽  
Laminin 332

Anti-laminin 332 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by predominant mucosal lesions and autoantibodies against laminin 332. The exact diagnosis of anti-laminin 332 MMP is important since nearly 30% of patients develop solid cancers. This study compared two independently developed diagnostic indirect immunofluorescence (IF) tests based on recombinant laminin 332 expressed in HEK239 cells (biochip mosaic assay) and the migration trails of cultured keratinocytes rich in laminin 332 (footprint assay). The sera of 54 anti-laminin 332 MMP, 35 non-anti-laminin 332 MMP, and 30 pemphigus vulgaris patients as well as 20 healthy blood donors were analyzed blindly and independently. Fifty-two of 54 and 54/54 anti-laminin 332 MMP sera were positive in the biochip mosaic and the footprint assay, respectively. In the 35 non-anti-laminin 332 MMP sera, 3 were positive in both tests and 4 others showed weak reactivity in the footprint assay. In conclusion, both assays are easy to perform, highly sensitive, and specific, which will further facilitate the diagnosis of anti-laminin 332 MMP.

Autoimmune Blistering Disease with Concurrent IgG Antibodies to Desmoglein 1 and BP180 : Two Cases

2013 ◽  
Vol 75 (5) ◽  
pp. 415-418
Author(s):  
Miki ICHIKAWA ◽  
Maya TANAKA ◽  
Kazunori URABE ◽  
Masutaka FURUE
Keyword(s):  
Igg Antibodies ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease

Sweet Syndrome and Pemphigus Vulgaris

2012 ◽  
Vol 16 (2) ◽  
pp. 128-130 ◽  
Author(s):  
Ashley O'toole ◽  
Maureen O'malley
Keyword(s):  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Neutrophilic Dermatosis ◽  
Rare Presentation ◽  
Sweet Syndrome ◽  
Autoimmune Blistering Disease ◽  
Mucous Membranes ◽  
Blistering Disease ◽  
Erythematous Plaques ◽  
New Onset

Background: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes. Sweet syndrome is an uncommon reactive neutrophilic dermatosis. Objective: This case report describes the rare presentation of a 58-year-old female patient with newly diagnosed pemphigus vulgaris who later presented with erythematous plaques and leukocytosis highly suggestive of Sweet syndrome. Methods: Review of the literature using the PubMed and Medline databases. Results: The clinical presentation of new-onset Sweet syndrome in a patient with pemphigus has been reported in the literature only on one other occasion. Conclusion: The observation of an association between Sweet syndrome and autoimmune diseases, such as pemphigus vulgaris, may ultimately lead to better understanding of the pathophysiology of this disease.

scholarly journals Pemphigus herpetiformis : A rare clinical variant of pemphigus

2016 ◽  
Vol 13 (1) ◽  
pp. 61-65
Author(s):  
P Shrestha ◽  
R B Tajhya ◽  
A Pokharel
Keyword(s):  
Inflammatory Infiltrate ◽  
Autoimmune Blistering Disease ◽  
Neutrophilic Dermatoses ◽  
Clinical Variant ◽  
Blistering Disease ◽  
Anti Inflammatory

Pemphigus herpetiformis is an autoimmune blistering disease. We report a case of pemphigus herpetiformis, a generalized form, manifested as pruritic grouped vesicles at extremities and trunk, in a seventy years old man. Neutrophil dominant inflammatory substrate was seen in histopathology. Direct immunofluorescene revealed IgG reactivity in net like pattern at upper epidermis, confirming pemphigus. The patient responded well to prednisolone and colchicine combination initially and maintained remission later on colchicine alone. Colchicine has anti-mitotic, anti-inflammatory and immunosuppressive mechanism of actions and proven benefits in neutrophilic dermatoses. Therefore we recommend colchicine as mono therapy or in combination with immunosuppressive, for the treatment of pemphigus herpetiformis where neutrophil is predominant inflammatory infiltrate histologically.NJDVL Vol. 13, No. 1, 2015 Page: 61-65

scholarly journals Blistering Diseases in a Tertiary Care Hospital: A 10-year Audit

2020 ◽  
Vol 18 (1) ◽  
pp. 24-27
Author(s):  
Niraj Parajuli ◽  
Laila Lama ◽  
Anupama Karki ◽  
Rushma Shrestha ◽  
Sumida Tiwari ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Tertiary Care ◽  
Length Of Hospital Stay ◽  
Referral Hospital ◽  
Care Hospital ◽  
Medical Sciences ◽  
Mortality And Morbidity ◽  
Autoimmune Blistering Disease ◽  
Dermatological Disease ◽  
Blistering Disease

Introduction: Cutaneous blisters can occur in variety of conditions. They are broadly classified as immunobullous or non-immunobullous. Immunobullous blistering diseases can further classify as intraepidermal or subepidermal. Non-immunobullous blistering disease are commonly due to infections, drugs among others. Some of the blistering disease carry significant mortality and morbidity. There are only limited data on blistering diseases from Nepal, so this study will provide details on the prevalence of this rare dermatological disease from one of the tertiary care referral hospital in the country. Objective: To assess the clinical pattern and prevalence of various blistering diseases in a tertiary care referral hospital. Materials and Methods: All of the data were obtained from the admission register maintained at department of dermatology and venereology, National Academy of Medical Sciences. All the patients admitted with blistering disease from year April 2008 till March 2018 were included. The details including age, sex, type of blistering disease and length of hospital stay were recorded.  Results: A total of 710 patients were admitted in the dermatology ward over the period of 10 years.  There were a total of 193 blistering disease admitted during this period. Autoimmune blistering disease was diagnosed in 59 patients whereas 100 patients had non-immunobullous disease. The age grouped range from 4- 93 years with the mean age of 43± 19.71 years. The average number of hospital stay of all blistering diseases was 11.73±11.36 days. Conclusion: Blistering diseases are one of the most common conditions requiring admission in dermatology ward. Some of these diseases carry a significant morbidity and mortality. So, prompt diagnosis and treatment is of utmost importance.

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