scholarly journals Pemphigus herpetiformis : A rare clinical variant of pemphigus

2016 ◽  
Vol 13 (1) ◽  
pp. 61-65
Author(s):  
P Shrestha ◽  
R B Tajhya ◽  
A Pokharel
Keyword(s):  
Inflammatory Infiltrate ◽  
Autoimmune Blistering Disease ◽  
Neutrophilic Dermatoses ◽  
Clinical Variant ◽  
Blistering Disease ◽  
Anti Inflammatory

Pemphigus herpetiformis is an autoimmune blistering disease. We report a case of pemphigus herpetiformis, a generalized form, manifested as pruritic grouped vesicles at extremities and trunk, in a seventy years old man. Neutrophil dominant inflammatory substrate was seen in histopathology. Direct immunofluorescene revealed IgG reactivity in net like pattern at upper epidermis, confirming pemphigus. The patient responded well to prednisolone and colchicine combination initially and maintained remission later on colchicine alone. Colchicine has anti-mitotic, anti-inflammatory and immunosuppressive mechanism of actions and proven benefits in neutrophilic dermatoses. Therefore we recommend colchicine as mono therapy or in combination with immunosuppressive, for the treatment of pemphigus herpetiformis where neutrophil is predominant inflammatory infiltrate histologically.NJDVL Vol. 13, No. 1, 2015 Page: 61-65

Autoimmune Blistering Disease with Concurrent IgG Antibodies to Desmoglein 1 and BP180 : Two Cases

2013 ◽  
Vol 75 (5) ◽  
pp. 415-418
Author(s):  
Miki ICHIKAWA ◽  
Maya TANAKA ◽  
Kazunori URABE ◽  
Masutaka FURUE
Keyword(s):  
Igg Antibodies ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease

Sweet Syndrome and Pemphigus Vulgaris

2012 ◽  
Vol 16 (2) ◽  
pp. 128-130 ◽  
Author(s):  
Ashley O'toole ◽  
Maureen O'malley
Keyword(s):  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Neutrophilic Dermatosis ◽  
Rare Presentation ◽  
Sweet Syndrome ◽  
Autoimmune Blistering Disease ◽  
Mucous Membranes ◽  
Blistering Disease ◽  
Erythematous Plaques ◽  
New Onset

Background: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes. Sweet syndrome is an uncommon reactive neutrophilic dermatosis. Objective: This case report describes the rare presentation of a 58-year-old female patient with newly diagnosed pemphigus vulgaris who later presented with erythematous plaques and leukocytosis highly suggestive of Sweet syndrome. Methods: Review of the literature using the PubMed and Medline databases. Results: The clinical presentation of new-onset Sweet syndrome in a patient with pemphigus has been reported in the literature only on one other occasion. Conclusion: The observation of an association between Sweet syndrome and autoimmune diseases, such as pemphigus vulgaris, may ultimately lead to better understanding of the pathophysiology of this disease.

scholarly journals Blistering Diseases in a Tertiary Care Hospital: A 10-year Audit

2020 ◽  
Vol 18 (1) ◽  
pp. 24-27
Author(s):  
Niraj Parajuli ◽  
Laila Lama ◽  
Anupama Karki ◽  
Rushma Shrestha ◽  
Sumida Tiwari ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Tertiary Care ◽  
Length Of Hospital Stay ◽  
Referral Hospital ◽  
Care Hospital ◽  
Medical Sciences ◽  
Mortality And Morbidity ◽  
Autoimmune Blistering Disease ◽  
Dermatological Disease ◽  
Blistering Disease

Introduction: Cutaneous blisters can occur in variety of conditions. They are broadly classified as immunobullous or non-immunobullous. Immunobullous blistering diseases can further classify as intraepidermal or subepidermal. Non-immunobullous blistering disease are commonly due to infections, drugs among others. Some of the blistering disease carry significant mortality and morbidity. There are only limited data on blistering diseases from Nepal, so this study will provide details on the prevalence of this rare dermatological disease from one of the tertiary care referral hospital in the country. Objective: To assess the clinical pattern and prevalence of various blistering diseases in a tertiary care referral hospital. Materials and Methods: All of the data were obtained from the admission register maintained at department of dermatology and venereology, National Academy of Medical Sciences. All the patients admitted with blistering disease from year April 2008 till March 2018 were included. The details including age, sex, type of blistering disease and length of hospital stay were recorded.  Results: A total of 710 patients were admitted in the dermatology ward over the period of 10 years.  There were a total of 193 blistering disease admitted during this period. Autoimmune blistering disease was diagnosed in 59 patients whereas 100 patients had non-immunobullous disease. The age grouped range from 4- 93 years with the mean age of 43± 19.71 years. The average number of hospital stay of all blistering diseases was 11.73±11.36 days. Conclusion: Blistering diseases are one of the most common conditions requiring admission in dermatology ward. Some of these diseases carry a significant morbidity and mortality. So, prompt diagnosis and treatment is of utmost importance.

scholarly journals Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Rita Cascão ◽  
Bruno Vidal ◽  
Helena Raquel ◽  
Ana Neves-Costa ◽  
Nuno Figueiredo ◽  
...  
Keyword(s):  
Tumour Necrosis ◽  
Inflammatory Infiltrate ◽  
Cellular Proliferation ◽  
Inflammatory Diseases ◽  
Gambogic Acid ◽  
Antiproliferative Effects ◽  
Inflammatory Score ◽  
Anti Inflammatory ◽  
Acid Administration ◽  
Necrosis Factor

Background. We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1βlevels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1βpathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early RA treatment. We have recently identified gambogic acid as a promising therapeutic candidate to simultaneously block IL-1βand TNF secretion. Our main goal here was to investigate whether gambogic acid administration was able to attenuate inflammation in antigen-induced arthritis (AIA) rats.Methods. Gambogic acid was administered to AIA rats in the early and late phases of arthritis. The inflammatory score, ankle perimeter, and body weight were evaluated during the period of treatment. Rats were sacrificed after 19 days of disease progression and paw samples were collected for histological and immunohistochemical evaluation.Results. We found that inflammation in joints was significantly suppressed following gambogic acid administration. Histological and immunohistochemical evaluation of treated rats revealed normal joint structures with complete abrogation of the inflammatory infiltrate and cellular proliferation.Conclusions. Our results suggest that gambogic acid has significant anti-inflammatory properties and can possibly constitute a prototype anti-inflammatory drug with therapeutic efficacy in the treatment of inflammatory diseases such as RA.

Development of a Novel Assay for Autoimmune Blistering Disease

2010 ◽  
Vol 135 ◽  
pp. S46
Author(s):  
Jean-Baptiste Barbaroux ◽  
John Mee ◽  
Hui Li Kwong ◽  
Richard Groves
Keyword(s):  
Autoimmune Blistering Disease ◽  
Blistering Disease

A Spontaneous Canine Model of Mucous Membrane (Cicatricial) Pemphigoid, an Autoimmune Blistering Disease Affecting Mucosae and Mucocutaneous Junctions

2001 ◽  
Vol 16 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Thierry Olivry ◽  
Stanley M Dunston ◽  
Marianne Schachter ◽  
Luting Xu ◽  
Ngon Nguyen ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Canine Model ◽  
Cicatricial Pemphigoid ◽  
Autoimmune Blistering Disease ◽  
Blistering Disease

scholarly journals A Possible Role for CD8+ T Lymphocytes in the Cell-Mediated Pathogenesis of Pemphigus Vulgaris

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Federica Giurdanella ◽  
Luca Fania ◽  
Maria Gnarra ◽  
Paola Toto ◽  
Daniela Di Rollo ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Immunohistochemical Staining ◽  
Inflammatory Infiltrate ◽  
Pemphigus Vulgaris ◽  
Skin Lesions ◽  
Passive Transfer ◽  
Autoimmune Blistering Disease ◽  
Deficient Mice

Pemphigus vulgaris (PV) is an autoimmune blistering disease whose pathogenesis involves both humoral and cell-mediated immune response. Though the pathogenetic role of autoantibodies directed against desmoglein 3 is certain, a number of other factors have been suggested to determine acantholysis in PV. In this study we examined the possible role of CD8+ T cells in the development of acantholysis by a passive transfer of PV autoantibodies using CD8 deficient mice, and we also studied the inflammatory infiltrate of PV skin lesions by immunohistochemical staining. The results of the immunohistochemical staining to study the expression of CD3, CD4, and CD8 in PV skin lesions showed that CD4+ are more expressed than CD8+ in the inflammatory infiltrate of PV lesions, confirming the data of the previous literature. The passive transfer study showed a lower incidence of pemphigus in the group of CD8 deficient mice compared to the control one of wild-type mice. These results suggest that CD8+ T cells may play a role in the pathogenesis of PV, perhaps through the Fas/FasL pathway.

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