Refined Solution Structure and Dynamics of the DNA-binding Domain of the Heat Shock Factor fromKluyveromyces lactis

1995 ◽  
Vol 254 (4) ◽  
pp. 704-719 ◽  
Author(s):  
F.F. Damberger ◽  
J.G. Pelton ◽  
C. Liu ◽  
H. Cho ◽  
C.J. Harrison ◽  
...  
Keyword(s):  
Heat Shock ◽  
Dna Binding ◽  
Solution Structure ◽  
Heat Shock Factor ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Structure And Dynamics

Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11 1 1Edited by P. E. Wright

2000 ◽  
Vol 296 (2) ◽  
pp. 351-359 ◽  
Author(s):  
Maria J.P van Dongen ◽  
Anna Cederberg ◽  
Peter Carlsson ◽  
Sven Enerbäck ◽  
Mats Wikström
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Solution Structure ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Structure And Dynamics

Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor

1994 ◽  
Vol 1 (9) ◽  
pp. 605-614 ◽  
Author(s):  
Geerten W. Vuister ◽  
Soon-Jong Kim ◽  
András Orosz ◽  
John Marquardt ◽  
Carl Wu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Shock ◽  
Dna Binding ◽  
Solution Structure ◽  
Binding Domain ◽  
Heat Shock Transcription Factor ◽  
Dna Binding Domain

scholarly journals The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster

Structure ◽  
1994 ◽  
Vol 2 (7) ◽  
pp. 609-627 ◽  
Author(s):  
David NM Jones ◽  
M.Alexandra Searles ◽  
Graeme L Shaw ◽  
Mair EA Churchill ◽  
Sarbjit S Ner ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Dna Binding ◽  
Solution Structure ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Structure And Dynamics

scholarly journals Roles of His101in DNA-Binding Domain of Human Heat Shock Factor 1 Under Acid pH Environment

2012 ◽  
Vol 33 (12) ◽  
pp. 4201-4203
Author(s):  
Ming Lu ◽  
Bobae Kwon ◽  
Ziwei Chang ◽  
Hyeon-Gyeong Park ◽  
Jang-Su Park
Keyword(s):  
Heat Shock ◽  
Dna Binding ◽  
Heat Shock Factor ◽  
Binding Domain ◽  
Heat Shock Factor 1 ◽  
Dna Binding Domain ◽  
Acid Ph

scholarly journals The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive.

1995 ◽  
Vol 15 (8) ◽  
pp. 4309-4318 ◽  
Author(s):  
Y Shi ◽  
P E Kroeger ◽  
R I Morimoto
Keyword(s):  
Heat Shock ◽  
Dna Binding ◽  
Transcriptional Activation ◽  
Heat Shock Factor ◽  
Binding Domain ◽  
Heat Shock Factor 1 ◽  
Dna Binding Domain ◽  
Activation Domain ◽  
Transcriptional Activation Domain ◽  
Carboxyl Terminal

We have characterized a stress-responsive transcriptional activation domain of mouse heat shock factor 1 (HSF1) by using chimeric GAL4-HSF1 fusion proteins. Fusion of the GAL4 DNA-binding domain to residues 124 to 503 of HSF1 results in a chimeric factor that binds DNA yet lacks any transcriptional activity. Transactivation is acquired upon exposure to heat shock or by deletion of a negative regulatory domain including part of the DNA-binding-domain-proximal leucine zippers. Analysis of a collection of GAL4-HSF1 deletion mutants revealed the minimal region for the constitutive transcriptional activator to map within the extreme carboxyl-terminal 108 amino acids, corresponding to a region rich in acidic and hydrophobic residues. Loss of residues 395 to 425 or 451 to 503, which are located at either end of this activation domain, severely diminished activity, indicating that the entire domain is required for transactivation. The minimal activation domain of HSF1 also confers enhanced transcriptional response to heat shock or cadmium treatment. These results demonstrate that the transcriptional activation domain of HSF1 is negatively regulated and that the signal for stress induction is mediated by interactions between the amino-terminal negative regulator and the carboxyl-terminal transcriptional activation domain.

Alpha-helix 1 in the DNA-binding domain of heat shock factor 1 regulates its heat-induced trimerization and DNA-binding

2009 ◽  
Vol 385 (4) ◽  
pp. 612-617 ◽  
Author(s):  
Ming Lu ◽  
Kwang-Jea Sohn ◽  
Si-Won Kim ◽  
Chun-Ri Li ◽  
Suhkmann Kim ◽  
...  
Keyword(s):  
Heat Shock ◽  
Dna Binding ◽  
Alpha Helix ◽  
Heat Shock Factor ◽  
Binding Domain ◽  
Heat Shock Factor 1 ◽  
Dna Binding Domain

Letter to Editor: Solution structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric β-barrel fold

2004 ◽  
Vol 30 (2) ◽  
pp. 211-214 ◽  
Author(s):  
Alejandro D. Nadra ◽  
Tommaso Eliseo ◽  
Yu-Keung Mok ◽  
Fabio C.L. Almeida ◽  
Mark Bycroft ◽  
...  
Keyword(s):  
Dna Binding ◽  
Solution Structure ◽  
Transcriptional Regulator ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Hpv 16

scholarly journals Solution Structure of the DNA-Binding Domain of the Tomato Heat-Stress Transcription Factor HSF24

1996 ◽  
Vol 236 (3) ◽  
pp. 911-921 ◽  
Author(s):  
Jurgen Schultheiss ◽  
Olaf Kunert ◽  
Uwe Gase ◽  
Klaus-Dieter Scharf ◽  
Lutz Nover ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Heat Stress ◽  
Dna Binding ◽  
Solution Structure ◽  
Binding Domain ◽  
Dna Binding Domain
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