Comparison of Skeletal Muscle Laser Doppler Flowmetry to Changes in Central Hemodynamics in Detecting the Physiological Response to Moderate Hemorrhage

1995 ◽  
Vol 58 (2) ◽  
pp. 189-192 ◽  
Author(s):  
Agustin A. Rodriguez ◽  
Glenn P. Gardner ◽  
Wayne W. Lamorte ◽  
Eliot T. Obi-Tabot ◽  
C.Robert Valeri ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Laser Doppler Flowmetry ◽  
Physiological Response ◽  
Laser Doppler ◽  
Central Hemodynamics ◽  
Doppler Flowmetry

Assessment of muscle blood flow by laser-Doppler flowmetry during hemorrhage in SHR

1990 ◽  
Vol 259 (3) ◽  
pp. H860-H865
Author(s):  
J. H. Lombard ◽  
R. J. Roman
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Muscle Blood Flow ◽  
Control Period ◽  
Tissue Perfusion ◽  
Gracilis Muscle ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Skeletal Muscle Blood Flow

Skeletal muscle blood flow was assessed via laser-Doppler flowmetry (LDF) in the gracilis muscle of anesthetized 12- to 15-wk-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) control rats subjected to graded hemorrhage. Tissue perfusion was assessed at 20 specific sites in the muscle before and 20 min after each of five successive 1-ml withdrawals of blood. Mean LDF signals recorded from the gracilis muscle of SHR and WKY were similar during the prehemorrhage control period. After hemorrhage, mean arterial pressure and calculated vascular resistance of the gracilis muscle were higher in SHR than in WKY, and SHR exhibited a greater reduction of LDF signal in response to hemorrhage than WKY. Although SHR and WKY had a similar number of low flow sites (LDF signal less than 0.17 V) during the control period, successive blood volume withdrawals led to a significantly greater increase in the number of poorly perfused areas in the muscles of the hypertensive animals. The results of this study suggest that LDF is a useful tool to assess tissue perfusion during circulatory stress and that hemorrhage causes a greater decrease in skeletal muscle blood flow in SHR than in WKY. More severe reductions in tissue perfusion may contribute to the reduced ability of hypertensive animals to survive after hypotensive hemorrhage.

Haemodynamic responses to temperature changes of human skeletal muscle studied by laser-Doppler flowmetry

2012 ◽  
Vol 33 (7) ◽  
pp. 1181-1197 ◽  
Author(s):  
Tiziano Binzoni ◽  
David Tchernin ◽  
Jonas Richiardi ◽  
Dimitri Van De Ville ◽  
Jean-Noël Hyacinthe
Keyword(s):  
Skeletal Muscle ◽  
Laser Doppler Flowmetry ◽  
Human Skeletal Muscle ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Temperature Changes

Effect of hyperoxemia and ritanserin on skeletal muscle microflow

1990 ◽  
Vol 68 (4) ◽  
pp. 1494-1500 ◽  
Author(s):  
P. Thorborg ◽  
U. Gustafsson ◽  
F. Sjoberg ◽  
D. K. Harrison ◽  
D. H. Lewis
Keyword(s):  
Skeletal Muscle ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Muscle Oxygenation ◽  
Doppler Flowmetry ◽  
Group I ◽  
Skeletal Muscle Oxygenation ◽  
Group Ii ◽  
The Right ◽  
Hydrogen Clearance

Serotonin2 (5-HT2) receptor antagonists (ketanserin, ritanserin) can normalize a hyperoxemia-induced disturbance in skeletal muscle oxygenation, presumably by local microflow changes. The purpose of this study was to develop equipment for local hydrogen clearance measurements with a modified eight-channel platinum electrode to assess changes in local skeletal muscle capillary blood flow induced by hyperoxemia and ritanserin (0.035 mg/kg) during hyperoxemia. Laser-Doppler flowmetry was used for regional microflow measurements. Two groups of six anesthetized and artificially ventilated rabbits were studied: group I with normoxemia and hyperoxemia [arterial PO2 (PaO2) 48 kPa; 360 Torr] and group II before and after ritanserin with hyperoxemia (PaO2 46 kPa; 345 Torr). In group I, hyperoxemia induced a mean local hydrogen clearance decrease of 22% while laser-Doppler flowmetry signal decreased 31%. In group II, ritanserin induced a 125% mean local hydrogen clearance increase compared with hyperoxemia (or 37% compared with group I normoxemia); laser-Doppler flowmetry signal increased 30%. The sum distribution of local hydrogen clearances shifted to the left during hyperoxemia and to the right after ritanserin. The conclusion from this study is that local and regional microflow changes can explain the effects of hyperoxemia and ritanserin on skeletal muscle oxygenation.

scholarly journals Opportunities and limitations of laser Doppler flowmetry in the assessment of skin microcirculation in patients with arterial hypertenstion

2015 ◽  
Vol 14 (1) ◽  
pp. 41-45
Author(s):  
A. P. Vasilev ◽  
N. N. Streltsova
Keyword(s):  
Laser Doppler Flowmetry ◽  
Clinical Medicine ◽  
Individual Characteristics ◽  
Laser Doppler ◽  
Central Hemodynamics ◽  
Skin Microcirculation ◽  
Doppler Flowmetry ◽  
Functional Dynamics ◽  
Clinical Conditions ◽  
To Receive

Introduction. Assessment of microcirculation by laser Doppler flowmetry (LDF) is widely applied in clinical medicine. Though, it is important to highlight the difficulty of getting stable results of LDF in the skin microvessels and their interpretation in patients with arterial hypertension (AH). This study was undertaken to address this issue. Results and discussion. Based on both available literature and our data, high functional dynamics and individual characteristics of microcirculation (MC) parameters and spatial heterogeneity of mircovascular (MV) channel was demonstrated. Interpretation difficulties of research results, connected to these factors, can be eliminated using certain methodology. Incorrect interpretation of MC parameters can be caused by ignorance of central hemodynamics features, with no estimation of bloodstream distribution. Conclusion. Consideration of the listed factors will allow to receive more accurate physiological interpretation of MC parameters in the skin - the most reachable object in clinical conditions.

Vasomotion in rat skeletal muscle induced by hemorrhage as recorded by laser-doppler flowmetry

1991 ◽  
Vol 42 (2) ◽  
pp. 224-228 ◽  
Author(s):  
Urban Gustafsson ◽  
Karin Wårdell ◽  
Gert E. Nilsson ◽  
David H. Lewis
Keyword(s):  
Skeletal Muscle ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Rat Skeletal Muscle ◽  
Doppler Flowmetry

Cutaneous laser-Doppler flowmetry: influence of underlying muscle blood flow

1988 ◽  
Vol 65 (1) ◽  
pp. 478-481 ◽  
Author(s):  
J. L. Saumet ◽  
D. L. Kellogg ◽  
W. F. Taylor ◽  
J. M. Johnson
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Muscle Blood Flow ◽  
Ventral Surface ◽  
Skin Surface ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Forearm Exercise ◽  
Opening And Closing

To find whether the measurement of skin blood flow (SkBF) by laser-Doppler flowmetry (LDF) is influenced by blood flow to underlying skeletal muscle, five subjects performed mild forearm exercise to induce a metabolic hyperemia in muscle in both forearms. This exercise consisted of alternative opening and closing of both hands at a frequency of approximately 1/s for a duration of 3 min. This exercise was performed twice by each subject. Forearm blood flow (FBF) by plethysmography increased from 2.64 +/- 0.49 (rest) to 31.11 +/- 9.95 ml.100 ml-1.min-1 (immediately after exercise) (P less than 0.001). No statistically significant postexercise increase was observed in LDF measured on the dorsal (110 +/- 21 to 105 +/- 21 mV) or ventral surface (266 +/- 113 to 246 +/- 77 mV) of the forearm. LDF measured from the chest also showed no significant change, indicating that the exercise was too mild to have reflex effects on SkBF. Moreover, the slope of the logarithmic linear regression and the half-time for recovery during the postexercise period for FBF were not reflected in LDF measurements from any of the three sites. We conclude that LDF measured from the skin surface is not influenced by blood flow to underlying skeletal muscle.

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