Platelet Glycoprotein IIb/IIIa Receptor Antagonist (Abciximab) Inhibited Platelet Activation and Promoted Skin Flap Survival after Ischemia/Reperfusion Injury

2002 ◽  
Vol 107 (1) ◽  
pp. 50-55
Author(s):  
Yur-Ren Kuo ◽  
Seng-Feng Jeng ◽  
Feng-Sheng Wang ◽  
Hui-Chen Huang ◽  
Fu-Chan Wei ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Reperfusion Injury ◽  
Platelet Activation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Skin Flap ◽  
Platelet Glycoprotein ◽  
Flap Survival ◽  
Skin Flap Survival

Improved skin flap survival in venous ischemia-reperfusion injury with the use of adipose-derived stem cells

Microsurgery ◽  
2015 ◽  
Vol 35 (8) ◽  
pp. 645-652 ◽  
Author(s):  
Hyun Ho Han ◽  
Young Min Lim ◽  
Sang Wook Park ◽  
Su Jin Lee ◽  
Jong Won Rhie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Skin Flap ◽  
Adipose Derived Stem Cells ◽  
Flap Survival ◽  
Skin Flap Survival ◽  
Venous Ischemia

scholarly journals Ischemia and reperfusion in skin flaps: effects of mannitol and vitamin C in reducing necrosis area in a rat experimental model

2005 ◽  
Vol 20 (5) ◽  
pp. 358-363 ◽  
Author(s):  
Winston Bonetti Yoshida ◽  
Eloísa Bueno Pires de Campos
Keyword(s):  
Vitamin C ◽  
Experimental Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Skin Flap ◽  
Skin Flaps ◽  
Flap Survival ◽  
Ringer’S Solution ◽  
Skin Flap Survival ◽  
Lactated Ringer's Solution

PURPOSE: The aim of the present study was to develop an experimental model of ischemia-reperfusion injury in rat skin flap and to verify the effect of mannitol and vitamin C on reducing necrosis area. METHODS: A 6-x 3-cm groin skin flap was raised and submitted to 8 hours of ischemia by clamping the vascular pedicle and to 7 days of reperfusion. The animals were divided in four groups: S1 and S2 (10 animals each) and C and T (14 animals each). In groups S1 and S2 skin flaps were not submitted to ischemia and animals received lactated Ringer's solution (S1) and antioxidant solution (S2 ). In groups C and T, flaps were subjected to 8 hours of warm ischemia and animals received Lactated Ringer's solution (Group C) and antioxidant solution immediately before reperfusion, (Group T). Flap survival was evaluated on the seventh day using a paper template technique and computer-assistant imaging analysis of necrotic and normal areas. RESULTS: Statistical analysis showed no area differences between groups C and T. CONCLUSION: The experimental model provided consistent necrotic area in control groups and drugs used were not effective in improving skin flap survival.

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