Cannabinoid CB1 Receptor Expression in Rat Spinal Cord

2000 ◽  
Vol 15 (6) ◽  
pp. 510-521 ◽  
Author(s):  
W.Paul Farquhar-Smith ◽  
Michaela Egertová ◽  
Elizabeth J. Bradbury ◽  
Stephen B. McMahon ◽  
Andrew S.C. Rice ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cb1 Receptor ◽  
Receptor Expression ◽  
Cannabinoid Cb1 Receptor ◽  
Rat Spinal Cord

scholarly journals Upregulation of EphA Receptor Expression in the Injured Adult Rat Spinal Cord

2002 ◽  
Vol 11 (3) ◽  
pp. 229-239 ◽  
Author(s):  
Christopher A. Willson ◽  
Margarita Irizarry-Ramírez ◽  
Hope E. Gaskins ◽  
Lillian Cruz-Orengo ◽  
Johnny D. Figueroa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Gray Matter ◽  
Receptor Expression ◽  
Axonal Guidance ◽  
Receptor Subtypes ◽  
Rat Spinal Cord ◽  
Functional Connections ◽  
Cord Injury ◽  
Epha Receptor

After spinal cord injury (SCI), the inability of supraspinal neurons to regenerate or reform functional connections is likely due to proteins in the surrounding microenvironment restricting regeneration. EphAs are a family of receptor tyrosine kinases that are involved in axonal guidance during development. These receptors and their ligands, the Ephrins, act via repulsive mechanisms to guide growing axons towards their appropriate targets and allow for the correct developmental connections to be made. In the present study, we investigated whether EphA receptor expression changed after a thoracic contusion SCI. Our results indicate that several EphA molecules are upregulated after SCI. Using semiquantitative RT-PCR to investigate mRNA expression after SCI, we found that EphA3, A4, and A7 mRNAs were upregulated. EphA3, A4, A6, and A8 receptor immunoreactivity increased in the ventrolateral white matter (VWM) at the injury epicenter. EphA7 had the highest level of immunoreactivity in both control and injured rat spinal cord. EphA receptor expression in the white matter originated from glial cells as coexpression in both astrocytes and oligodendrocytes was observed. In contrast, gray matter expression was localized to neurons of the ventral gray matter (motor neurons) and dorsal horn. After SCI, specific EphA receptor subtypes are upregulated and these increases may create an environment that is unfavorable for neurite outgrowth and functional regeneration.

scholarly journals Association between Cannabinoid CB1 Receptor Expression and Akt Signalling in Prostate Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65798 ◽  
Author(s):  
Mariateresa Cipriano ◽  
Jenny Häggström ◽  
Peter Hammarsten ◽  
Christopher J. Fowler
Keyword(s):  
Prostate Cancer ◽  
Cb1 Receptor ◽  
Receptor Expression ◽  
Cannabinoid Cb1 Receptor

Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models

2003 ◽  
Vol 17 (12) ◽  
pp. 2750-2754 ◽  
Author(s):  
Ji Zhang ◽  
Cyrla Hoffert ◽  
Huy Khang Vu ◽  
Thierry Groblewski ◽  
Sultan Ahmad ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Receptor Expression ◽  
Cb2 Receptor ◽  
Rat Spinal Cord ◽  
Pain Models

Modulation of NMDA receptor expression in the rat spinal cord by peripheral nerve injury and adrenal medullary grafting

1995 ◽  
Vol 687 (1-2) ◽  
pp. 103-113 ◽  
Author(s):  
Aldric T. Hama ◽  
James R. Unnerstall ◽  
Julie B. Siegan ◽  
Jacqueline Sagen
Keyword(s):  
Spinal Cord ◽  
Nmda Receptor ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Receptor Expression ◽  
Rat Spinal Cord

Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord

2005 ◽  
Vol 491 (1) ◽  
pp. 56-68 ◽  
Author(s):  
Xiao Hong Yu ◽  
Alfredo Ribeiro da Silva ◽  
Yves De Koninck
Keyword(s):  
Spinal Cord ◽  
Receptor Expression ◽  
Rat Spinal Cord ◽  
Neurokinin 1 Receptor ◽  
Lamina I ◽  
Neurokinin 1
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