scholarly journals The Sequence and Antiapoptotic Functional Domains of the Human Cytomegalovirus UL37 Exon 1 Immediate Early Protein Are Conserved in Multiple Primary Strains

Virology ◽  
2001 ◽  
Vol 279 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Wail A. Hayajneh ◽  
Anamaris M. Colberg-Poley ◽  
Anna Skaletskaya ◽  
Laura M. Bartle ◽  
Marci M. Lesperance ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Functional Domains ◽  
Early Protein ◽  
Multiple Primary ◽  
Exon 1

scholarly journals Human Cytomegalovirus Immediate-Early Protein IE2 Tethers a Transcriptional Repression Domain to p53

1996 ◽  
Vol 271 (7) ◽  
pp. 3534-3540 ◽  
Author(s):  
Hsiu-Lan Tsai ◽  
Guang-Hsiung Kou ◽  
Shan-Chun Chen ◽  
Cheng-Wen Wu ◽  
Young-Sun Lin
Keyword(s):  
Human Cytomegalovirus ◽  
Transcriptional Repression ◽  
Immediate Early ◽  
Early Protein ◽  
Repression Domain

scholarly journals Correction to: Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis

2020 ◽  
Author(s):  
Le Wen ◽  
Fei Zhao ◽  
Yong Qiu ◽  
Shuang Cheng ◽  
Jin-Yan Sun ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Original Publication ◽  
Early Protein

In the original publication the email addresses of corresponding authors have not been displayed. The correct email addresses of corresponding authors are provided in this correction. Fang-Cheng Li ([email protected]), Fei Hu ([email protected]), Min-Hua Luo ([email protected]).

scholarly journals The human cytomegalovirus US3 immediate-early protein lacking the putative transmembrane domain regulates gene expression

1993 ◽  
Vol 21 (12) ◽  
pp. 2931-2937 ◽  
Author(s):  
Daniel J. Tenney ◽  
Linda D. Santomenna ◽  
Karyn B. Goudie ◽  
Anamaris M. Colberg-Poley
Keyword(s):  
Gene Expression ◽  
Human Cytomegalovirus ◽  
Transmembrane Domain ◽  
Immediate Early ◽  
Putative Transmembrane Domain ◽  
Early Protein

scholarly journals Internal cleavage of the human cytomegalovirus UL37 immediate-early glycoprotein and divergent trafficking of its proteolytic fragments

2004 ◽  
Vol 85 (7) ◽  
pp. 1989-1994 ◽  
Author(s):  
Manohara S. Mavinakere ◽  
Anamaris M. Colberg-Poley
Keyword(s):  
Endoplasmic Reticulum ◽  
Human Cytomegalovirus ◽  
Cleavage Site ◽  
Immediate Early ◽  
Signal Peptidase ◽  
Signal Sequences ◽  
Terminal Fragment ◽  
Exon 1

The human cytomegalovirus UL37 gene encodes at least three isoforms, which share N-terminal UL37 exon 1 (UL37x1) sequences. UL37 proteins traffic dually into the endoplasmic reticulum (ER) and to mitochondria. Trafficking of the UL37 glycoprotein (gpUL37) in relation to its post-translational processing was investigated. gpUL37 is internally cleaved in the ER and its products traffic differentially. Its C-terminal fragment (UL37COOH) is ER-localized and N-glycosylated. Unlike conventional ER signal sequences, its N-terminal () fragment is stable and traffics to mitochondria. Inhibition of N-glycosylation did not block pUL37 cleavage and dramatically decreased the levels of but not of UL37COOH. pUL37M, which differs from gpUL37 by the lack of residues 178–262 and hence the UL37x3 consensus signal peptidase cleavage site, traffics into the ER and mitochondria, but is neither cleaved nor N-glycosylated. This finding of a relationship between ER processing and mitochondrial importation of UL37 proteins is unique for herpesvirus proteins.

Dual regulatory role of human cytomegalovirus immediate-early protein in IL1B transcription is dependent upon Spi-1/PU.1

2002 ◽  
Vol 294 (4) ◽  
pp. 854-863 ◽  
Author(s):  
Zhiyong Yang ◽  
Nawarat Wara-aswapati ◽  
Yasuhiro Yoshida ◽  
Nancy Walker ◽  
Deborah L Galson ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Regulatory Role ◽  
Early Protein

scholarly journals Infection of APC by Human Cytomegalovirus Controlled Through Recognition of Endogenous Nuclear Immediate Early Protein 1 by Specific CD4+T Lymphocytes

2002 ◽  
Vol 169 (3) ◽  
pp. 1293-1301 ◽  
Author(s):  
Emmanuelle Le Roy ◽  
Michel Baron ◽  
Wolfgang Faigle ◽  
Danièle Clément ◽  
David M. Lewinsohn ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Early Protein

Subcellular localization of the major immediate early protein (IE1) of human cytomegalovirus at early times after infection

Virology ◽  
1988 ◽  
Vol 162 (2) ◽  
pp. 478-482 ◽  
Author(s):  
Steven M. Otto ◽  
Glenda Sullivan-Tailyour ◽  
Cheryl L. Malone ◽  
Mark F. Stinski
Keyword(s):  
Subcellular Localization ◽  
Human Cytomegalovirus ◽  
Immediate Early ◽  
Early Protein
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