scholarly journals Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions

2017 ◽  
pp. 189-215 ◽  
Author(s):  
Christopher Pittenger
Keyword(s):  
Tourette Syndrome ◽  
Knockout Mice ◽  
Histidine Decarboxylase

scholarly journals Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear

2015 ◽  
Vol 595 ◽  
pp. 50-53 ◽  
Author(s):  
Meiyu Xu ◽  
Lina Li ◽  
Hiroshi Ohtsu ◽  
Christopher Pittenger
Keyword(s):  
Tourette Syndrome ◽  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Genetic Model

Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: A study in histidine decarboxylase gene knockout mice

2005 ◽  
Vol 522 (1-3) ◽  
pp. 55-62 ◽  
Author(s):  
Akiko Yoshida ◽  
Jalal Izadi Mobarakeh ◽  
Eiko Sakurai ◽  
Shinobu Sakurada ◽  
Tohru Orito ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Gene Knockout ◽  
Gene Knockout Mice ◽  
Histamine H1 Receptors

scholarly journals Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice

FEBS Letters ◽  
2001 ◽  
Vol 508 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Carlos P. Fitzsimons ◽  
Eszter Lazar-Molnar ◽  
Zsuzsa Tomoskozi ◽  
Edit Buzás ◽  
Elena S. Rivera ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Receptor Expression ◽  
Down Regulation ◽  
Histamine H2 Receptor ◽  
Tissue Specific ◽  
H2 Receptor

New functions of histamine found in histidine decarboxylase gene knockout mice

2003 ◽  
Vol 305 (3) ◽  
pp. 443-447 ◽  
Author(s):  
Hiroshi Ohtsu ◽  
Takehiko Watanabe
Keyword(s):  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Gene Knockout ◽  
Gene Knockout Mice

scholarly journals Genetic animal models of Tourette syndrome: The long and winding road from lab to clinic

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
Ruben Cauchi ◽  
Zsanett Tárnok
Keyword(s):  
Animal Models ◽  
Tourette Syndrome ◽  
Histidine Decarboxylase ◽  
Genetic Model ◽  
Transmembrane Protein ◽  
Human Condition ◽  
Genetic Modifiers ◽  
Therapeutic Drugs ◽  
Genetic Aberration ◽  
Sleep Abnormalities

AbstractTourette syndrome (TS) is a disabling neuropsychiatric disorder characterised by persistent motor and vocal tics. TS is a highly comorbid state, hence, patients might experience anxiety, obsessions, compulsions, sleep abnormalities, depression, emotional liability, learning problems, and attention deficits in addition to tics. In spite of its complex heterogeneous genetic aetiology, recent studies highlighted a strong link between TS and genetic lesions in the HDC (L-histidine decarboxylase) gene, which encodes the enzyme that synthetises histamine, and the SLITRK1 (SLIT and TRK-like family member 1) gene, which encodes a transmembrane protein that was found to regulate neurite outgrowth. In addition to validating the contribution of a specific genetic aberration to the development of a particular pathology, animal models are crucial to dissect the function of disease-linked proteins, expose disease pathways through examination of genetic modifiers and discover as well as assess therapeutic strategies. Mice with a knockout of either Hdc or Slitrk1 exhibit anxiety and those lacking Hdc, display dopamine agonist-triggered stereotypic movements. However, the mouse knockouts do not spontaneously display tics, which are recognised as the hallmark of TS. In this review, we explore the features of the present genetic animal models of TS and identify reasons for their poor resemblance to the human condition. Importantly, we highlight ways forward aimed at developing a valuable genetic model of TS or a model that has good predictive validity in developing therapeutic drugs for the treatment of tics, hence potentially accelerating the arduous journey from lab to clinic.

scholarly journals Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness

SLEEP ◽  
2019 ◽  
Vol 42 (5) ◽  
Author(s):  
Xiao Yu ◽  
Ying Ma ◽  
Edward C Harding ◽  
Raquel Yustos ◽  
Alexei L Vyssotski ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Nrem Sleep ◽  
Delta Power ◽  
Adult Mice ◽  
Sleep Homeostasis ◽  
Normal Sleep ◽  
Wake State

Abstract Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start of the lights-off period, when they remained sleepier. The amount of time spent in NREM sleep and in the wake state in mice with lesioned HA neurons was unchanged over 24 hr, but the sleep–wake cycle was more fragmented. Both the delayed increase in wakefulness at the start of the night and the sleep–wake fragmentation are similar phenotypes to histidine decarboxylase knockout mice, which cannot synthesize HA. Chronic loss of HA neurons did not affect sleep homeostasis after sleep deprivation. However, the chronic loss of HA neurons or chemogenetic inhibition of HA neurons did notably reduce the ability of the wake-promoting compound modafinil to sustain wakefulness. Thus, part of modafinil’s wake-promoting actions arise through the HA system.

scholarly journals Nitric Oxide Mediates T Cell Cytokine Production and Signal Transduction in Histidine Decarboxylase Knockout Mice

2007 ◽  
Vol 179 (10) ◽  
pp. 6613-6619 ◽  
Author(s):  
Agnes Koncz ◽  
Maria Pasztoi ◽  
Mercedesz Mazan ◽  
Ferenc Fazakas ◽  
Edit Buzas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
T Cell ◽  
Knockout Mice ◽  
Cytokine Production ◽  
Histidine Decarboxylase ◽  
Cell Cytokine Production

scholarly journals Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice

Neuron ◽  
2014 ◽  
Vol 81 (1) ◽  
pp. 77-90 ◽  
Author(s):  
Lissandra Castellan Baldan ◽  
Kyle A. Williams ◽  
Jean-Dominique Gallezot ◽  
Vladimir Pogorelov ◽  
Maximiliano Rapanelli ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Histidine Decarboxylase ◽  
Decarboxylase Deficiency

Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice

2005 ◽  
Vol 14 (3) ◽  
pp. 169-175 ◽  
Author(s):  
M. Seike ◽  
M. Ikeda ◽  
H. Kodama ◽  
T. Terui ◽  
H. Ohtsu
Keyword(s):  
Contact Dermatitis ◽  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Gene Knockout ◽  
Gene Knockout Mice

Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity

2010 ◽  
Vol 48 (5) ◽  
pp. 727-735 ◽  
Author(s):  
Yao Shen ◽  
Ping He ◽  
Yan-ying Fan ◽  
Jian-xiang Zhang ◽  
Hai-jing Yan ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Glutamate Excitotoxicity
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