scholarly journals Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice

FEBS Letters ◽  
2001 ◽  
Vol 508 (2) ◽  
pp. 245-248 ◽  
Author(s):  
Carlos P. Fitzsimons ◽  
Eszter Lazar-Molnar ◽  
Zsuzsa Tomoskozi ◽  
Edit Buzás ◽  
Elena S. Rivera ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Receptor Expression ◽  
Down Regulation ◽  
Histamine H2 Receptor ◽  
Tissue Specific ◽  
H2 Receptor

Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice

2006 ◽  
Vol 51 (3) ◽  
pp. 612-622 ◽  
Author(s):  
Jalal Izadi Mobarakeh ◽  
Kazuhiro Takahashi ◽  
Shinobu Sakurada ◽  
Atsuo Kuramasu ◽  
Kazuhiko Yanai
Keyword(s):  
Knockout Mice ◽  
Gene Knockout ◽  
Receptor Gene ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Antinociceptive Effects ◽  
Gene Knockout Mice

scholarly journals Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri

mBio ◽  
2015 ◽  
Vol 6 (6) ◽  
Author(s):  
Chunxu Gao ◽  
Angela Major ◽  
David Rendon ◽  
Monica Lugo ◽  
Vanessa Jackson ◽  
...  
Keyword(s):  
Lactobacillus Reuteri ◽  
Intestinal Inflammation ◽  
Histidine Decarboxylase ◽  
Model Systems ◽  
Colonic Inflammation ◽  
Histamine H2 Receptor ◽  
Content Type ◽  
Intestinal Microbes ◽  
H2 Receptor ◽  
Probiotic Strains

ABSTRACT Probiotics and commensal intestinal microbes suppress mammalian cytokine production and intestinal inflammation in various experimental model systems. Limited information exists regarding potential mechanisms of probiotic-mediated immunomodulation in vivo. In this report, we demonstrate that specific probiotic strains of Lactobacillus reuteri suppress intestinal inflammation in a trinitrobenzene sulfonic acid (TNBS)-induced mouse colitis model. Only strains that possess the hdc gene cluster, including the histidine decarboxylase and histidine-histamine antiporter genes, can suppress colitis and mucosal cytokine (interleukin-6 [IL-6] and IL-1β in the colon) gene expression. Suppression of acute colitis in mice was documented by diminished weight loss, colonic injury, serum amyloid A (SAA) protein concentrations, and reduced uptake of [18F]fluorodeoxyglucose ([18F]FDG) in the colon by positron emission tomography (PET). The ability of probiotic L. reuteri to suppress colitis depends on the presence of a bacterial histidine decarboxylase gene(s) in the intestinal microbiome, consumption of a histidine-containing diet, and signaling via the histamine H2 receptor (H2R). Collectively, luminal conversion of l-histidine to histamine by hdc + L. reuteri activates H2R, and H2R signaling results in suppression of acute inflammation within the mouse colon. IMPORTANCE Probiotics are microorganisms that when administered in adequate amounts confer beneficial effects on the host. Supplementation with probiotic strains was shown to suppress intestinal inflammation in patients with inflammatory bowel disease and in rodent colitis models. However, the mechanisms of probiosis are not clear. Our current studies suggest that supplementation with hdc + L. reuteri, which can convert l-histidine to histamine in the gut, resulted in suppression of colonic inflammation. These findings link luminal conversion of dietary components (amino acid metabolism) by gut microbes and probiotic-mediated suppression of colonic inflammation. The effective combination of diet, gut bacteria, and host receptor-mediated signaling may result in opportunities for therapeutic microbiology and provide clues for discovery and development of next-generation probiotics.

Functional analyses of the histamine H2 receptor using H2 receptor knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A102-A103
Author(s):  
Y FUKUSHIMA ◽  
T SAITOH ◽  
T ISHIKAWA ◽  
M OMATA
Keyword(s):  
Knockout Mice ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Functional Analyses

Histamine Receptor Expression, Hippocampal Plasticity and Ammonia in Histidine Decarboxylase Knockout Mice

2011 ◽  
Vol 32 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Aisa Chepkova ◽  
Evgenij Yanovsky ◽  
Regis Parmentier ◽  
Hiroshi Ohtsu ◽  
Helmut L. Haas ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Histidine Decarboxylase ◽  
Histamine Receptor ◽  
Receptor Expression ◽  
Hippocampal Plasticity

scholarly journals Suppression of rat stomach histidine decarboxylase activity by histamine: H2-receptor-mediated feed-back

1977 ◽  
Vol 269 (3) ◽  
pp. 643-667 ◽  
Author(s):  
R. Håkanson ◽  
L.-I. Larsson ◽  
G. Liedberg ◽  
J. F. Rehfeld ◽  
F. Sundler
Keyword(s):  
Histidine Decarboxylase ◽  
Decarboxylase Activity ◽  
Rat Stomach ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Histidine Decarboxylase Activity

The C Terminal Tail of the Histamine H2 Receptor Contains Positive and Negative Signals Important for Signal Transduction and Receptor Down-Regulation

2002 ◽  
Vol 67 (5) ◽  
pp. 1791-1800 ◽  
Author(s):  
M. J. Smit ◽  
H. Timmerman ◽  
J. Blauw ◽  
M. W. Beukers ◽  
E. Roovers ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Down Regulation ◽  
Histamine H2 Receptor ◽  
H2 Receptor

Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis

2014 ◽  
Vol 127 (7) ◽  
pp. 435-448 ◽  
Author(s):  
Zhi Zeng ◽  
Liang Shen ◽  
Xixian Li ◽  
Tao Luo ◽  
Xuan Wei ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Fibrosis ◽  
Cardiac Fibroblasts ◽  
Down Regulation ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Mitochondrial Permeability ◽  
Myocardial Apoptosis ◽  
Heart Failure Progression

In the present study, we have shown that H2R deficiency or blockade could reduce cardiac fibrosis through the down-regulation of calcineurin expression in cardiac fibroblasts and reduce myocardial apoptosis through lowering of mitochondrial permeability in cardiomyocytes, finally achieving the goal of improving heart failure.

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