scholarly journals KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway

2020 ◽  
Author(s):  
Paige M. Estave ◽  
Mary B. Spodnick ◽  
Anushree N. Karkhanis
Keyword(s):  
Mesolimbic Dopamine ◽  
Mesolimbic Dopamine Pathway

scholarly journals Corticosterone enhances N-methyl-d-aspartate receptor signaling to promote isolated ventral tegmental area activity in a reconstituted mesolimbic dopamine pathway

2016 ◽  
Vol 120 ◽  
pp. 159-165 ◽  
Author(s):  
Jennifer N. Berry ◽  
Meredith A. Saunders ◽  
Lynda J. Sharrett-Field ◽  
Anna R. Reynolds ◽  
Michael T. Bardo ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Receptor Signaling ◽  
Mesolimbic Dopamine ◽  
Aspartate Receptor ◽  
Ventral Tegmental ◽  
Mesolimbic Dopamine Pathway

4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels

2019 ◽  
Vol 237 (3) ◽  
pp. 757-772 ◽  
Author(s):  
Arvie Abiero ◽  
Chrislean Jun Botanas ◽  
Raly James Custodio ◽  
Leandro Val Sayson ◽  
Mikyung Kim ◽  
...  
Keyword(s):  
Mesolimbic Dopamine ◽  
Reinforcing Effects ◽  
Mesolimbic Dopamine Pathway

Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

Science ◽  
2006 ◽  
Vol 311 (5762) ◽  
pp. 864-868 ◽  
Author(s):  
O. Berton
Keyword(s):  
Essential Role ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Mesolimbic Dopamine ◽  
Mesolimbic Dopamine Pathway

Brain-Derived Neurotrophic Factor And The Plasticity Of The Mesolimbic Dopamine Pathway

2004 ◽  
pp. 425-444 ◽  
Author(s):  
Oliver Guillin ◽  
Nathalie Griffon ◽  
Jorge Diaz ◽  
Bernard Le Foll ◽  
Erwan Bezard ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Mesolimbic Dopamine ◽  
Mesolimbic Dopamine Pathway

scholarly journals Lipid signalling in the mesolimbic dopamine pathway

2018 ◽  
Vol 44 (1) ◽  
pp. 221-222 ◽  
Author(s):  
Stephanie Fulton ◽  
Thierry Alquier
Keyword(s):  
Mesolimbic Dopamine ◽  
Lipid Signalling ◽  
Mesolimbic Dopamine Pathway

scholarly journals Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway

2016 ◽  
Vol 36 (18) ◽  
pp. 5160-5169 ◽  
Author(s):  
Justine Renard ◽  
Michael Loureiro ◽  
Laura G. Rosen ◽  
Jordan Zunder ◽  
Cleusa de Oliveira ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Behavioral Sensitization ◽  
Kinase Signaling ◽  
Mesolimbic Dopamine ◽  
P70s6 Kinase ◽  
Mesolimbic Dopamine Pathway ◽  
Kinase Signaling Pathway

scholarly journals Alterations in excitatory and inhibitory synaptic development within the mesolimbic dopamine pathway in a mouse model of prenatal drug exposure

2020 ◽  
Author(s):  
Taylor Boggess ◽  
Hannah Sexton ◽  
Anna Mazur ◽  
Richard D. Egleton ◽  
Lawrence M. Grover ◽  
...  
Keyword(s):  
Mouse Model ◽  
Drug Exposure ◽  
Drugs Of Abuse ◽  
Prenatal Drug Exposure ◽  
Opioid Abuse ◽  
Mesolimbic Dopamine ◽  
Synaptic Development ◽  
Microscopy Imaging ◽  
The Mean ◽  
Mesolimbic Dopamine Pathway

AbstractThe rise in rates of opioid abuse in recent years has led to an increase in the incidence of neonatal abstinence syndrome (NAS). Despite having a greater understanding of NAS and its symptoms, there still remains a lack of information surrounding the long-term effects of prenatal exposure to drugs of abuse on neurological development. One potential outcome of prenatal drug exposure that has been increasingly explored is disruption in normal synaptogenesis within the central nervous system. Both opioids and gabapentin, an antiepileptic drug commonly co-abused by opioid abuse disorder patients, have been shown to interfere with the normal functioning of astrocytes, non-neuronal glial cells known to serve many functions, including regulation of synaptic development. The goal of this study was to investigate the effects of prenatal drug exposure on synaptogenesis within brain regions associated with the mesolimbic dopamine pathway, the primary reward pathway within the brain associated with drug abuse and addiction, in a pregnant mouse model. Immunohistochemistry (IHC) and confocal fluorescence microscopy imaging studies on the brains of postnatal day 21 (P21) mouse pups revealed a significant increase in the mean number of excitatory synapses within the anterior cingulate cortex (ACC), nucleus accumbens (NAc), and prefrontal cortex (PFC) in mice that were prenatally exposed to either the opioid drug buprenorphine or gabapentin. These studies also revealed a significant decrease in the mean number of inhibitory synapses within the NAc and PFC of mice treated with buprenorphine. This observed net increase in excitatory signaling capability within the developing mesolimbic dopamine pathway suggests that exposure to drugs of abuse in utero can trigger maladaptive neuronal connectivity that persists beyond the earliest stages of life.

The Mesolimbic Dopamine Pathway and Romantic Love

Brain Mapping ◽  
2015 ◽  
pp. 631-633 ◽  
Author(s):  
X. Xu ◽  
X. Weng ◽  
A. Aron
Keyword(s):  
Romantic Love ◽  
Mesolimbic Dopamine ◽  
Mesolimbic Dopamine Pathway

scholarly journals Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway

2019 ◽  
Vol 10 (5) ◽  
pp. 2125-2143 ◽  
Author(s):  
Samantha E. Yohn ◽  
Jordan Galbraith ◽  
Erin S. Calipari ◽  
P. Jeffrey Conn
Keyword(s):  
Eating Disorder ◽  
Binge Eating ◽  
Drug Addiction ◽  
Binge Eating Disorder ◽  
Mesolimbic Dopamine ◽  
Group I ◽  
Group I Mglurs ◽  
Mesolimbic Dopamine Pathway
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