Telomere Length and Oxidative Stress in Patients with ST-Segment Elevation and Non-ST-Segment Elevation Myocardial Infarction

Abstract Objective Reperfusion of ischemic myocardium generates oxidative stress, which itself can mediate myocardial injury. So, in this study, we investigated the level of oxidative stress markers and its association with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Results As indicated in the results, Post MI (Myocardial Infarction) heart failure was significantly higher in the group A (11% vs 4%, p = 0.047). Complete STR (ST-segment resolution) was observed to be significantly higher in the group B (36% vs 17%, p = 0.006). The SOD (Superoxide dismutase) and GPX (Glutathione peroxidase) levels were significantly higher in the group B compared to the other group (1547.51 ± 328.29 vs. 1449.97 ± 246.06, p = 0.019 and 60.62 ± 11.95 vs 57.41 ± 10.14, p = 0.042). The levels of GPX and SOD were shown to be directly related with complete STR and post PCI (Percutaneous coronary intervention)TIMI(Thrombolysis in Myocardial Infarction) flow 3 in the group A (p = 0.002 and p < 0.01, p = 0.005 and p < 0.02, respectively).

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Oxidative Stress and Paraoxonase 1 Activity Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Angiology ◽

10.1177/0003319714533588 ◽

2014 ◽

Vol 66 (4) ◽

pp. 339-345 ◽

Cited By ~ 27

Author(s):

Abdurrezzak Börekçi ◽

Mustafa Gür ◽

Caner Türkoğlu ◽

Murat Çaylı ◽

Şahbettin Selek ◽

...

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Percutaneous Coronary Intervention ◽

Coronary Intervention ◽

Paraoxonase 1 ◽

Contrast Induced Nephropathy ◽

St Segment Elevation ◽

Segment Elevation Myocardial Infarction ◽

St Segment ◽

Percutaneous Coronary

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Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation (STEMI) -relationship with oxidative stress

Archives of Medical Science ◽

10.5114/aoms/136074 ◽

2021 ◽

Author(s):

Aleksandra Vukašinović ◽

Barbara Ostanek ◽

Aleksandra Klisic ◽

Srdjan Kafedžić ◽

Marija Zdravković ◽

...

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Blood Vessel ◽

Telomere Length ◽

Telomerase Activity ◽

Control Group ◽

Leukocyte Telomere Length ◽

St Segment Elevation ◽

St Segment ◽

Vessel Rupture

IntroductionWe aimed to find association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction (AMI). Furthermore, association of telomere-telomerase system with oxidative stress markers was tested.Material and methodsLeukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated.ResultsPatients were divided into: stabile angina pectoris (AP) (n=22), AMI with: ST-segment elevation (STEMI) (n=93), non-obstructive coronary arteries (MINOCA) (n=7), blood vessel rupture (n=6) in three time points, and compared to with 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group [AP=0.373 (0.355-0.386), STEMI=0.375 (0.349-0.395), MINOCA=0.391 (0.366-0.401), blood vessel rupture=0.360 (0.352-0.385) vs CG=0.069 (0.061-0.081), p=0.000], while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture compared to the control group [STEMI=1.179 (0.931-1.376), MINOCA=1.026 (0.951-1.070), blood vessel rupture=1.089 (0.842-1.173) vs CG=1.329 (1.096-1.624), p=0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to control group and AP patients [5.83 (4.55-7.54) and 10.28 (9.19-10.72) vs 4.94 (3.29-6.18) and 4.18 (2.58-4.86), p=0.000]. Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to peripheral blood leukocytes in the same patients [1.25 (1.01 - 1.84) vs 1.18 (0.909 - 1.516), p=0.036; and 0.366 (0.367 - 0.379) vs 0.366 (0.367 - 0.379), p=0.000, respectively]. Telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from controls.ConclusionsLeukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.

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