Over-the-Counter Codeine—from Therapeutic Use to Dependence, and the Grey Areas in Between

Author(s):  
Suzanne Nielsen ◽  
Marie Claire Van Hout

2021 ◽  
Author(s):  
Tomasz Zaprutko ◽  
Dorota Kopciuch ◽  
Anna Paczkowska ◽  
Józefina Sprawka ◽  
Julia Cynar ◽  
...  

BACKGROUND Over the last decade, we’ve observed an enormous social media development, which have recently become commercial services. OBJECTIVE The objective was to verify Facebook as a source of pharmaceuticals offers. We also intended to identify prescription (Rx) and over-the-counter (OTC) medicines if available on that platform. METHODS The study was conducted from January 2019 to July 2020. We investigated offers of pharmaceuticals posted on the Polish Facebook (individual posts and communities) between 2016 and 2019. Medicines were divided into Rx and OTC brands and in accordance with their possible therapeutic use. We verified whether the medicines were for sale, to exchange, or available for free. Posts and groups were investigated for example by entering the phrase “for free,” followed by a city in Poland. RESULTS Out of 409 offers, 380 (92.91%) concerned Rx brands and 29 OTC brands. 315 (77.02%) medications were available “for free”. In 47 (11.49%) cases, an “exchange” was expected, and 47 (11.49%) announcements were marked as “for sale”. Cardiovascular medicines (n=125) were the most popular. There were also antidiabetics (n=38) and antipsychotics (n=28). We also found clear candidates for misuse. These were opioids (n=7), benzodiazepines (n=2 )as well as clomifene (n=1) and letrozole (n=1). CONCLUSIONS Facebook is a significant source of uncontrolled access to medicines. The majority of offers concerned Rx brands, including opioids and benzodiazepines. Medicines offered on Facebook are mainly accessible for free, and the scope and the number of medicines offered on Facebook should make this issue a hazardous phenomenon.



Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.





1950 ◽  
Vol 34 (6) ◽  
pp. 1761-1777 ◽  
Author(s):  
Harold Jeghers ◽  
Irving B. Brick
Keyword(s):  


1993 ◽  
Vol 26 (5) ◽  
pp. 737-746 ◽  
Author(s):  
Edwin M. Monsell ◽  
Stephen P. Cass ◽  
Leonard P. Rybak


2012 ◽  
Vol 43 (8) ◽  
pp. 10 ◽  
Author(s):  
Frances Correa
Keyword(s):  








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