Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis

2021 ◽  
Author(s):  
Allen Jankeel ◽  
Izabela Coimbra-Ibraim ◽  
Ilhem Messaoudi
Keyword(s):  
Simian Varicella Virus ◽  
Molecular Virology ◽  
Varicella Virus

scholarly journals Intratracheal inoculation of human varicella zoster virus (VZV; MAV strain) vaccine successfully induced VZV IgG antibodies in rhesus monkeys

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Jong-Min Kim ◽  
Chung-Gyu Park
Keyword(s):  
Rhesus Monkey ◽  
Varicella Zoster Virus ◽  
Humoral Immunity ◽  
Antibody Production ◽  
Rhesus Monkeys ◽  
Igg Antibodies ◽  
Simian Varicella Virus ◽  
Varicella Zoster ◽  
Varicella Virus ◽  
Strain Vaccine

Abstract Background The objective of this study was to investigate whether the use of live attenuated varicella zoster virus (VZV) MAV vaccination can efficiently induce VZV antibody production in naive rhesus monkeys as an approach to prevent simian varicella virus (SVV) reactivation in animals immunosuppressed for transplantation studies. Results Clinically available human VZV vaccine was used to induce the production of anti-VZV antibodies in rhesus monkeys. A vial of the vaccine was subcutaneously injected at 0 week, and the second and third vaccination was performed at 5 and 6 weeks by intratracheal inoculation. The titer of anti-VZV IgG was assessed at 0, 2, 4, 6, and 7 weeks. At 2 weeks, 3/16 were seropositive for VZV IgG. At 6 weeks, 9/16 were shown to be seropositive. At 7 weeks, 16/16 were found to be seropositive. Conclusions The VZV vaccine via intratrachael inoculation was shown to induce VZV IgG humoral immunity in rhesus monkeys and may be important immunosuppressed macaques for transplantation studies. Although the humoral immunity produced is an important finding, further studies will be necessary to confirm possible protection and it could protect probably against SVV infection in rhesus monkey.

scholarly journals Robust pro-inflammatory and lesser anti-inflammatory immune responses during primary simian varicella virus infection and reactivation in rhesus macaques

2014 ◽  
Vol 20 (5) ◽  
pp. 526-530 ◽  
Author(s):  
Vicki Traina-Dorge ◽  
Robert Sanford ◽  
Stephanie James ◽  
Lara A. Doyle-Meyers ◽  
Eileen de Haro ◽  
...  
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Rhesus Macaques ◽  
Simian Varicella Virus ◽  
Varicella Virus ◽  
Anti Inflammatory

Pharmacokinetics and antiviral activity of a novel isonucleoside, BMS-181165, against simian varicella virus infection in African green monkeys

1994 ◽  
Vol 23 (3-4) ◽  
pp. 219-224 ◽  
Author(s):  
K.F. Soike ◽  
J.-L. Huang ◽  
J.W. Russell ◽  
V.J. Whiterock ◽  
J.E. Sundeen ◽  
...  
Keyword(s):  
Virus Infection ◽  
Antiviral Activity ◽  
Simian Varicella Virus ◽  
Varicella Virus ◽  
Green Monkeys

Enhancement of Simian Varicella Virus Infection in African Green Monkeys by Recombinant Human Tumor Necrosis Factor  

1989 ◽  
Vol 159 (2) ◽  
pp. 331-334 ◽  
Author(s):  
K. F. Soike ◽  
C. W. Czarnlecki ◽  
G. Baskin ◽  
J. Blanchard ◽  
D. Liggitt
Keyword(s):  
Tumor Necrosis Factor ◽  
Virus Infection ◽  
Tumor Necrosis ◽  
Human Tumor ◽  
Human Tumor Necrosis Factor ◽  
Simian Varicella Virus ◽  
Varicella Virus ◽  
Necrosis Factor ◽  
Green Monkeys

scholarly journals Simian Varicella Virus Pathogenesis

2010 ◽  
pp. 309-321 ◽  
Author(s):  
Ravi Mahalingam ◽  
Ilhem Messaoudi ◽  
Don Gilden
Keyword(s):  
Simian Varicella Virus ◽  
Varicella Virus

The genomes of simian varicella virus and varicella zoster virus are colinear

1992 ◽  
Vol 26 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Carla Y. Pumphrey ◽  
Wayne L. Gray
Keyword(s):  
Varicella Zoster Virus ◽  
Simian Varicella Virus ◽  
Varicella Zoster ◽  
Varicella Virus

Investigation of antiviral activity of 1-β-d-arabinofuranosylthymine (ara-T) and 1-β-d-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U) in monkeys infected with simian varicella virus

1984 ◽  
Vol 4 (5) ◽  
pp. 245-257 ◽  
Author(s):  
Kenneth F. Soike ◽  
Gary Baskin ◽  
Connie Cantrell ◽  
Peter Gerone
Keyword(s):  
Antiviral Activity ◽  
Simian Varicella Virus ◽  
Varicella Virus
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