Background. The major histocompatibility complex class I chain-related gene A
(MICA) (OMIM-600169) is a polymorphic gene in the HLA region expressed
mainly by epithelial cells. The MICA protein encoded by the allele
influences the activation of NK cells, which modify ?-cells destruction and
has been found to be involved in susceptibility of T1DM. Objective. The aim
of this study was to find the association of MICA alleles with T1DM among
eastern Indian population. Subjects and methods.Study was conducted in 134
eastern Indian patients and with 137 healthy controls for the possible role
of MICA gene in T1DM pathogenesis. Results. The MICA*A5 microsatellite
allele, showed significantly higher frequencies in patients than controls
(p=0.003, OR= 1.746, CI= 1.206-2.528). MICA A*6 was found to be protective
in our study (p=<0.01, OR=0.406, CI= 0.268-0.616).
Erratum to: Glutaric Acidemia Type 1-Clinico-Molecular Profile and Novel Mutations in GCDH Gene in Indian Patients
