Social Organization, Reproductive Systems, and Mediation of Baboon Endogenous Virus (BaEV) Copy Number in Gelada, Hamadryas, and Other Papio Baboons

2006 ◽  
pp. 123-143
Author(s):  
Monica Uddin ◽  
Jane E. Phillips-Conroy ◽  
Clifford J. Jolly
Keyword(s):  
Social Organization ◽  
Copy Number ◽  
Endogenous Virus ◽  
Reproductive Systems ◽  
Baboon Endogenous Virus

Syncytium formation induced by baboon endogenous virus in several transformed human cell lines

Virology ◽  
1981 ◽  
Vol 108 (1) ◽  
pp. 230-234 ◽  
Author(s):  
Terukazu Tanaka ◽  
Hajime Ogura ◽  
Munehiko Ocho ◽  
Masayoshi Namba ◽  
Sachiko Omura ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Cell ◽  
Syncytium Formation ◽  
Human Cell Lines ◽  
Endogenous Virus ◽  
Baboon Endogenous Virus

In Vivo Activation of the Baboon Endogenous Virus

1981 ◽  
Vol 166 (2) ◽  
pp. 271-276 ◽  
Author(s):  
J. W. Eichberg ◽  
S. S. Kalter ◽  
R. L. Heberling ◽  
D. A. Lawlor ◽  
J. D. Morrison ◽  
...  
Keyword(s):  
Endogenous Virus ◽  
Baboon Endogenous Virus

Cell receptors for baboon endogenous virus recognized by monoclonal antibodies.

1983 ◽  
Vol 48 (3) ◽  
pp. 697-708 ◽  
Author(s):  
L Thiry ◽  
J Cogniaux-LeClerc ◽  
R Olislager ◽  
S Sprecher-Goldberger ◽  
P Buekens
Keyword(s):  
Monoclonal Antibodies ◽  
Endogenous Virus ◽  
Cell Receptors ◽  
Baboon Endogenous Virus

Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6

Nature ◽  
1983 ◽  
Vol 301 (5896) ◽  
pp. 129-132 ◽  
Author(s):  
J. Craig Cohen ◽  
Michael Murphey-Corb
Keyword(s):  
Human Chromosome ◽  
Chromosome 6 ◽  
Endogenous Virus ◽  
Targeted Integration ◽  
Human Chromosome 6 ◽  
Baboon Endogenous Virus

scholarly journals Presence of Endogenous Viral Elements Negatively Correlates with Feline Leukemia Virus Susceptibility in Puma and Domestic Cat Cells

2020 ◽  
Vol 94 (21) ◽  
Author(s):  
Elliott S. Chiu ◽  
Sue VandeWoude
Keyword(s):  
Copy Number ◽  
Puma Concolor ◽  
Leukemia Virus ◽  
Domestic Cat ◽  
Feline Leukemia Virus ◽  
Domestic Cats ◽  
Endogenous Virus ◽  
Content Type ◽  
Copy Numbers ◽  
Felid Species

ABSTRACT While feline leukemia virus (FeLV) has been shown to infect felid species other than the endemic domestic cat host, differences in FeLV susceptibility among species has not been evaluated. Previous reports have noted a negative correlation between endogenous FeLV (enFeLV) copy number and exogenous FeLV (exFeLV) infection outcomes in domestic cats. Since felids outside the genus Felis do not harbor enFeLV genomes, we hypothesized absence of enFeLV results in more severe disease consequences in felid species lacking these genomic elements. We infected primary fibroblasts isolated from domestic cats (Felis catus) and pumas (Puma concolor) with FeLV and quantitated proviral and viral antigen loads. Domestic cat enFeLV env and long terminal repeat (LTR) copy numbers were determined for each individual and compared to FeLV viral outcomes. FeLV proviral and antigen levels were also measured in 6 naturally infected domestic cats and 11 naturally infected Florida panthers (P. concolor coryi). We demonstrated that puma fibroblasts are more permissive to FeLV than domestic cat cells, and domestic cat FeLV restriction was highly related to enFeLV-LTR copy number. Terminal tissues from FeLV-infected Florida panthers and domestic cats had similar exFeLV proviral copy numbers, but Florida panther tissues have higher FeLV antigen loads. Our work indicates that enFeLV-LTR elements negatively correlate with exogenous FeLV replication. Further, Puma concolor samples lacking enFeLV are more permissive to FeLV infection than domestic cat samples, suggesting that endogenization can play a beneficial role in mitigating exogenous retroviral infections. Conversely, presence of endogenous retroelements may relate to new host susceptibility during viral spillover events. IMPORTANCE Feline leukemia virus (FeLV) can infect a variety of felid species. Only the primary domestic cat host and related small cat species harbor a related endogenous virus in their genomes. Previous studies noted a negative association between the endogenous virus copy number and exogenous virus infection in domestic cats. This report shows that puma cells, which lack endogenous FeLV, produce more virus more rapidly than domestic cat fibroblasts following cell culture challenge. We document a strong association between domestic cat cell susceptibility and FeLV long terminal repeat (LTR) copy number, similar to observations in natural FeLV infections. Viral replication does not, however, correlate with FeLV env copy number, suggesting that this effect is specific to FeLV-LTR elements. This discovery indicates a protective capacity of the endogenous virus against the exogenous form, either via direct interference or indirectly via gene regulation, and may suggest evolutionary outcomes of retroviral endogenization.

scholarly journals Discovery of a New Endogenous Type C Retrovirus (FcEV) in Cats: Evidence for RD-114 Being an FcEVGag-Pol/Baboon Endogenous Virus BaEVEnv Recombinant

1999 ◽  
Vol 73 (10) ◽  
pp. 7994-8002 ◽  
Author(s):  
Antoinette C. van der Kuyl ◽  
John T. Dekker ◽  
Jaap Goudsmit
Keyword(s):  
De Novo ◽  
Germ Line ◽  
Endogenous Retrovirus ◽  
Domestic Cat ◽  
Papio Cynocephalus ◽  
Endogenous Virus ◽  
Dna Library ◽  
Genomic Dna Library ◽  
Type C ◽  
Baboon Endogenous Virus

ABSTRACT Analysis of a cat genomic DNA library showed that cats harbor a previously unrecognized endogenous type C retrovirus, whoseenv gene has homology to the murine Fv-4resistance gene. This unique retrovirus, designated FcEV (Felis catus endogenous retrovirus), has a type C pol gene, closely related to the primate Papio cynocephalusendogenous virus (PcEV) pol, not overlapping theenv gene, unlike in other type C retroviruses, and is presumably present in a higher copy number than RD-114. Phylogenetic analysis of FcEV and RD-114 fragments amplified from cat species and comparison with baboon endogenous virus (BaEV) fragments from monkeys suggested that RD-114 does not represent the cat strain of BaEV but is actually a new recombinant between FcEV type C genes and theenv gene of BaEV. Although BaEV did appear to have infected an ancestor of the domestic cat lineage, it was a de novo recombinant that made its way into the cat germ line.

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