Cytokines, “Depression Due to A General Medical Condition,” and Antidepressant Drugs

1999 ◽  
pp. 283-316 ◽  
Author(s):  
Raz Yirmiya ◽  
Joseph Weidenfeld ◽  
Yehuda Pollak ◽  
Michal Morag ◽  
Avraham Morag ◽  
...  
Keyword(s):  
Medical Condition ◽  
Antidepressant Drugs ◽  
General Medical Condition

scholarly journals In Silico and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Serotonin Reuptake Properties

2021 ◽  
Author(s):  
Alexey Sarapultsev ◽  
Pavel Vassiliev ◽  
Daniil Grinchii ◽  
Ruslan Paliokha ◽  
Andrey Kochetkov ◽  
...  
Keyword(s):  
Reuptake Inhibitor ◽  
In Silico ◽  
Serotonin Reuptake ◽  
Medical Condition ◽  
Partial Agonist ◽  
Antidepressant Drugs ◽  
Acute Administration ◽  
In Vivo Electrophysiology ◽  
General Medical Condition

L-17 is a thiadiazine derivative with putative anti-inflammatory, neuroprotective, and antidepressant-like properties. In this study, we applied combined in silico and in vivo electrophysiology techniques to reveal the potential mechanism of action of L-17. PASS 10.4 Professional Extended software suggested that L-17 might have pro-cognitive, antidepressant, and antipsychotic effects. Docking energy assessment with AutoDockVina predicted that the binding affinities of L-17 to the serotonin transporter (SERT) and serotonin receptors 3 and 1A (5-HT3 and 5-HT1A) are compatible to the selective serotonin reuptake inhibitor (SSRI) fluoxetine and selective antagonists of 5-HT3 and 5-HT1A receptors, granisetron and WAY100135, respectively. However, while the binding mechanisms of L-17 to the SERT and 5-HT1A receptor were similar to fluoxetine and WAY100135, its interacting with 5-HT3 receptor might be substantially different from this of granisetron. Acute administration of L-17 led to dose-dependent inhibition of firing activity of 5-HT neurons of the dorsal raphe nucleus. This inhibition was partially reversed by subsequent administration of WAY100135. Based on both in silico and in vivo electrophysiology assessments, we suggest that L-17 is a potent 5-HT reuptake inhibitor and a putative partial agonist of 5-HT1A receptors. As such, L-17 in particular and thiadiazine derivatives, in general, might be a representative of a new class of antidepressant drugs. Since L-17 also possesses neuro- and cardioprotective properties, it can be useful in affective illness developing due to the general medical condition, such as post-stroke and post-myocardial infarction (MI) depression.

Association between severity of schizophrenic symptoms and urinary retention

2001 ◽  
Vol 16 (8) ◽  
pp. 497-500 ◽  
Author(s):  
R. Shiloh ◽  
A. Weizman ◽  
P. Dorfman-Etrog ◽  
N. Weizer ◽  
H. Munitz
Keyword(s):  
Urinary Retention ◽  
Rating Scale ◽  
Medical Condition ◽  
Paranoid Schizophrenia ◽  
Temporal Correlation ◽  
Continuous Treatment ◽  
Psychotic Symptoms ◽  
General Medical Condition ◽  
Haloperidol Treatment ◽  
Psychotic Exacerbation

SummaryA case is presented in which severe urinary retention (UR) occurred during an acute psychotic exacerbation of paranoid schizophrenia. The voiding dysfunction was apparent during continuous treatment with unchanged doses of haloperidol, and it completely resolved with the remission of the psychotic symptoms. A clear temporal correlation was evident between the patient’s mental status, the Brief Psychiatric Rating Scale (BPRS) score and the degree of the UR as assessed by quantitatively measuring the total daily postvoiding urine residues. We could not relate the UR to any apparent general medical condition or to the haloperidol treatment. The presented data suggests that UR in schizophrenic patients might be the end-result of various psychosis-related mechanisms.

Anxiety Disorders in Palliative Care

2014 ◽  
pp. 19-28
Author(s):  
William S. Breitbart
Keyword(s):  
Palliative Care ◽  
Anxiety Disorders ◽  
Medical Condition ◽  
Terminally Ill ◽  
Adjustment Disorder ◽  
Assessment Tools ◽  
Pharmacological Agents ◽  
General Medical Condition ◽  
Severe Anxiety

Anxiety is common in palliative care patients and may significantly impact patients’ quality of life. Anxiety can have many etiologies resulting in different anxiety syndromes, ranging from adjustment disorder, anxiety resulting from general medical condition, to medication-induced anxiety disorders. Pre-existing anxiety disorders should also be taken into consideration in palliative care settings. Different screening and assessment tools have been used to improve recognition and assessment of anxiety in the terminally ill. Treatment of anxiety in this patient population includes use of a variety of pharmacological agents to relieve severe anxiety symptoms and use of psychotherapy interventions that have been shown to be safe and effective in the terminally ill. This chapter includes an overview of the prevalence, assessment, and management of anxiety disorders in palliative care settings.

Correlazioni positive tra spiritualità e salute: i risultati di alcune indagini / Positive correlations between spirituality and health: results from some surveys

2019 ◽  
Vol 68 (1) ◽  
pp. 41-54
Author(s):  
Paolo Morocutti
Keyword(s):  
Quality Of Life ◽  
Health Personnel ◽  
Medical Condition ◽  
Well Being ◽  
Close Correlation ◽  
General Medical Condition ◽  
Spirituality And Health ◽  
Positive Correlations ◽  
Positive Effect

La dimensione religiosa dell’uomo contribuisce in modo sostanziale al mantenimento della condizione medica generale, migliorando e preservando la qualità della vita. Quanto fa bene la fede? La preghiera fa ammalare meno e guarire prima? La partecipazione ai servizi religiosi porta realmente un effetto positivo sulla salute? Gli studi esaminati in questo articolo sembrano rispondere affermativamente a queste domande, evidenziando la stretta correlazione tra religiosità/spiritualità, salute e benessere fisico e psicologico. L’impatto antropologico e sociologico di tale realtà conduce ad evidenti riflessioni storiche e filosofiche, ma anche mediche e bioetiche, generando l’esigenza di una profonda trasformazione nella formazione del personale sanitario, dove l’aspetto religioso o spirituale non è ritenuto importante, né rilevante nell’approccio medico per la cura e l’assistenza del paziente. Nonostante ciò, numerosi studi approfondiscono ed attestano l’importanza di questo aspetto sia dei singoli, sia dell’intera popolazione. ---------- Religious dimension of man contributes substantially to maintain general medical condition, improving and preserving quality of life. How good is faith? Does prayer make you sick less and get better sooner? Does participation in religious services actually have a positive effect on health? The studies examined within this article seem to answer positively to these questions, highlighting the close correlation between religiosity / spirituality, health and physical and psychological well-being. The anthropological and sociological impact of this reality leads to evident historical and philosophical as well as medical and bioethical reflections, generating the need for a deep transformation of health personnel training, where the religious or spiritual aspect are not considered as important, nor relevant for medical approach to patient’s care. Nevertheless, several studies address and highlight the importance of this aspect for both individuals and whole population.

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