Novel Mechanisms of Estrogen Action

2007 ◽  
pp. 33-38 ◽  
Author(s):  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Action

MtTF4: An old tumor but a new model for studies of estrogen action on cell division

1984 ◽  
Vol 20 (6) ◽  
pp. 1634
Author(s):  
M.O. Pharaboz ◽  
V. Albaladejo ◽  
Y. Morel ◽  
O. Pascal ◽  
J. André
Keyword(s):  
Cell Division ◽  
Estrogen Action ◽  
New Model

scholarly journals Estrogen Action in Vitro

1972 ◽  
Vol 247 (4) ◽  
pp. 1299-1305
Author(s):  
Benita S. Katzenellenbogen ◽  
Jack Gorski
Keyword(s):  
Estrogen Action

scholarly journals The cerebellum as a target for estrogen action

2012 ◽  
Vol 33 (4) ◽  
pp. 403-411 ◽  
Author(s):  
Valerie L. Hedges ◽  
Timothy J. Ebner ◽  
Robert L. Meisel ◽  
Paul G. Mermelstein
Keyword(s):  
Estrogen Action

scholarly journals Morpholino-Mediated Knockdown of ERα, ERβa, and ERβb mRNAs in Zebrafish (Danio rerio) Embryos Reveals Differential Regulation of Estrogen-Inducible Genes

Endocrinology ◽  
2013 ◽  
Vol 154 (11) ◽  
pp. 4158-4169 ◽  
Author(s):  
Lucinda B. Griffin ◽  
Kathleen E. January ◽  
Karen W. Ho ◽  
Kellie A. Cotter ◽  
Gloria V. Callard
Keyword(s):  
Danio Rerio ◽  
Specific Gene ◽  
Estrogen Action ◽  
Cytochrome P450 Aromatase ◽  
Retained Intron ◽  
Inducible Genes ◽  
Hepatic Genes ◽  
Danio Rerio Embryos

Genetically distinct estrogen receptor (ER) subtypes (ERα and ERβ) play a major role in mediating estrogen actions in vertebrates, but their unique and overlapping functions are not entirely clear. Although mammals have 1 gene of each subtype (ESR1 and ESR2), teleost fish have a single esr1 (ERα) and 2 esr2 (ERβa and ERβb) genes. To determine the in vivo role of different ER isoforms in regulating estrogen-inducible transcription targets, zebrafish (Danio rerio) embryos were microinjected with esr-specific morpholino (MO) oligonucleotides to disrupt splicing of the exon III/intron III junction in the DNA-binding domain. Each MO knocked down its respective normal transcript and increased production of variants with a retained intron III (esr1 MO) or a deleted or mis-spliced exon III (esr2a and esr2b MOs). Both esr1 and esr2b MOs blocked estradiol induction of vitellogenin and ERα mRNAs, predominant hepatic genes, but esr2b was the only MO that blocked induction of cytochrome P450 aromatase B mRNA, a predominant brain gene. Knockdown of ERβa with the esr2a MO had no effect on estrogen induction of the 3 mRNAs but, when coinjected with esr1 MO, attenuated the effect of ERα knockdown. Results indicate that ERα and ERβb, acting separately or cooperatively on specific gene targets, are positive transcriptional regulators of estrogen action, but the role of ERβa, if any, is unclear. We conclude that MO technology in zebrafish embryos is an advantageous approach for investigating the interplay of ER subtypes in a true physiological context.

Estrogen Action in the Mouse Uterus: Adrenal Modulation of Receptor Levels

Endocrinology ◽  
1982 ◽  
Vol 110 (4) ◽  
pp. 1208-1216 ◽  
Author(s):  
VALERIE E. QUARMBY ◽  
CHRISTINE FOX-DAVIES ◽  
MARK H. SWAISGOOD ◽  
KENNETH S. KORACH
Keyword(s):  
Estrogen Action ◽  
Mouse Uterus

scholarly journals Central estrogen action sites involved in prepubertal restraint of pulsatile luteinizing hormone release in female rats

2015 ◽  
Vol 61 (4) ◽  
pp. 351-359 ◽  
Author(s):  
Yoshihisa UENOYAMA ◽  
Akira TANAKA ◽  
Kenji TAKASE ◽  
Shunji YAMADA ◽  
Vutha PHENG ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Female Rats ◽  
Hormone Release ◽  
Estrogen Action ◽  
Luteinizing Hormone Release

scholarly journals Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo

2008 ◽  
Vol 20 (5) ◽  
pp. 761-769 ◽  
Author(s):  
J. A. Clowes ◽  
G. Z. Eghbali-Fatourechi ◽  
L. McCready ◽  
M. J. Oursler ◽  
S. Khosla ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Postmenopausal Women ◽  
Estrogen Action

Estrogen action in the reproductive tract of rhesus monkeys during antiprogestin treatment.

Endocrinology ◽  
1993 ◽  
Vol 132 (4) ◽  
pp. 1845-1856 ◽  
Author(s):  
O D Slayden ◽  
J J Hirst ◽  
R M Brenner
Keyword(s):  
Rhesus Monkeys ◽  
Reproductive Tract ◽  
Estrogen Action
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