Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer’s Disease and Related Dementias

2021 ◽  
pp. 447-457
Author(s):  
Brian Spencer ◽  
Robert A. Rissman ◽  
Cassia Overk ◽  
Eliezer Masliah
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Chain ◽  
Single Chain Antibodies

Preparation and in vitro activity of single chain antibodies against Alzheimer's disease

2020 ◽  
Vol 227 ◽  
pp. 1-7
Author(s):  
Lu Fu ◽  
Yu Zhang ◽  
Xu Zhang ◽  
Wenhan Tian ◽  
Wenhui Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Single Chain ◽  
Single Chain Antibodies

scholarly journals Muscle-Directed Anti-Aβ Single-Chain Antibody Delivery via AAV1 Reduces Cerebral Aβ Load in an Alzheimer’s Disease Mouse Model

2012 ◽  
Vol 49 (2) ◽  
pp. 277-288 ◽  
Author(s):  
Junling Yang ◽  
Abhinandan Pattanayak ◽  
Min Song ◽  
Jinghong Kou ◽  
Hiroaki Taguchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Antibody Delivery

scholarly journals Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice

2010 ◽  
Vol 18 (8) ◽  
pp. 1471-1481 ◽  
Author(s):  
Deborah A Ryan ◽  
Michael A Mastrangelo ◽  
Wade C Narrow ◽  
Mark A Sullivan ◽  
Howard J Federoff ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning Behavior ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Aav Vector ◽  
Serotype 1 ◽  
Antibody Delivery

scholarly journals Anti-Aβ single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease

2006 ◽  
Vol 23 (3) ◽  
pp. 502-511 ◽  
Author(s):  
Ken-ichiro Fukuchi ◽  
Kazuki Tahara ◽  
Hong-Duck Kim ◽  
J. Adam Maxwell ◽  
Terry L. Lewis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Adeno Associated Virus ◽  
Antibody Delivery

scholarly journals Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities inDrosophilamodels of Alzheimer's disease

2015 ◽  
Vol 24 (21) ◽  
pp. 6093-6105 ◽  
Author(s):  
Pedro Fernandez-Funez ◽  
Yan Zhang ◽  
Jonatan Sanchez-Garcia ◽  
Lorena de Mena ◽  
Swati Khare ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Chain Variable Fragment ◽  
Single Chain
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