Prediction of plasma levels and clinical response in depression

1981 ◽  
pp. 263-271 ◽  
Author(s):  
Stuart A. Montgomery
Keyword(s):  
Clinical Response ◽  
Plasma Levels

The relationships between clinical response, psychophysiological variables and plasma levels of amitriptyline and diazepam in neurotic outpatients

1981 ◽  
Vol 72 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Eve C. Johnstone ◽  
Rachel C. Bourne ◽  
T. J. Crow ◽  
C. D. Frith ◽  
S. Gamble ◽  
...  
Keyword(s):  
Clinical Response ◽  
Plasma Levels

PLASMA LEVELS OF ANTIDEPRESSANTS AND CLINICAL RESPONSE

The Lancet ◽  
1973 ◽  
Vol 301 (7794) ◽  
pp. 95-96 ◽  
Author(s):  
Mats Gruvstad
Keyword(s):  
Clinical Response ◽  
Plasma Levels

BASELINE VENOUS ENDOTHELIN-1 (ET1) PLASMA LEVELS DOES NOT PREDICT CLINICAL RESPONSE TO BOSENTAN IN PULMONARY ARTERIAL HYPERTENSION

CHEST Journal ◽  
2005 ◽  
Vol 128 (4) ◽  
pp. 202S
Author(s):  
Carmine D. Vizza ◽  
Claudio Letizia ◽  
Roberto Badagliacca ◽  
Susanna Sciomer ◽  
Roberto Poscia ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Clinical Response ◽  
Plasma Levels ◽  
Endothelin 1 ◽  
Pulmonary Arterial

CORRELATION OF CLINICAL RESPONSE (PANSS) AND PLASMA LEVELS OF HALOPERIDOL AND REDUCED HALOPERIDOL IN SCHIZOPHRENIA.

1992 ◽  
Vol 15 ◽  
pp. 356B
Author(s):  
J. M. Leroux ◽  
E. Elia ◽  
M. Jacquet ◽  
J. Pommery ◽  
J. C. Levron ◽  
...  
Keyword(s):  
Clinical Response ◽  
Plasma Levels ◽  
Reduced Haloperidol

Haloperidol plasma levels and clinical response in paranoid schizophrenics

1984 ◽  
Vol 234 (4) ◽  
pp. 231-236 ◽  
Author(s):  
Paul Linkowski ◽  
Philippe Hubain ◽  
Remy Frenckell ◽  
Julien Mendlewicz
Keyword(s):  
Clinical Response ◽  
Plasma Levels

Fluphenazine plasma levels and clinical response

1985 ◽  
Vol 5 (1) ◽  
pp. 54
Author(s):  
Mavroidis MD ◽  
Kanter DR ◽  
Hirschowitz J ◽  
Garver D
Keyword(s):  
Clinical Response ◽  
Plasma Levels

P.3.c.059 Clozapine plasma levels, ABCB1 haplotype and clinical response to treatment in psychotic patients

2007 ◽  
Vol 17 ◽  
pp. S458-S459
Author(s):  
G. Consoli ◽  
M. Lastella ◽  
M. Catena ◽  
A. Ciapparelli ◽  
L. Ciofi ◽  
...  
Keyword(s):  
Clinical Response ◽  
Plasma Levels ◽  
Response To Treatment

Clozapine plasma levels and dosing strategies in patients with treatment-refractory schizophrenia

1997 ◽  
Vol 14 (3) ◽  
pp. 85-88 ◽  
Author(s):  
Peter F Buckley ◽  
Philip Cola ◽  
Mitsuru Hasegawa ◽  
Christine Lys ◽  
Paul Thompson
Keyword(s):  
Clinical Practice ◽  
Partial Response ◽  
Clinical Response ◽  
Clinical Improvement ◽  
Plasma Levels ◽  
Major Metabolite ◽  
The Other ◽  
Adequate Response ◽  
Dosing Strategies ◽  
Treatment Refractory

AbstractObjective: To determine the effect on clinical response to clozapine of increasing the plasma levels of clozapine and its major metabolite N-desmethylclozapine in 19 patients with schizophrenia who had plasma clozapine levels ≤ 370ng/ml, a level previously determined to identify patients who were unlikely to have an adequate response to clozapine.Method: The dosage of clozapine was increased by 20% in 11 patients and left unaltered in the other eight patients. Clozapine and N-desmethylclozapine plasma levels were measured after six weeks at the higher dose.Results: Nine of the 11 patients in whom clozapine dosage was increased subsequently achieved plasma clozapine levels ≥ 370ng/ml. However, in this group of patients who already had partially responded to clozapine, increasing the dosage of clozapine did not produce additional clinical improvement.Conclusion: Clozapine plasma levels are useful in clinical practice to guide dosage strategies. However, these results suggest that increasing the dosage of clozapine to achieve plasma levels ≥ 370ng/ml is unlikely to produce further improvement in patients who have already achieved a partial response to clozapine at plasma levels ≤ 370ng/ml.

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