Multidimensional NMR Studies of Immunosuppressant/Immunophilin Complexes

1993 ◽  
pp. 92-133
Author(s):  
Stephen W. Fesik ◽  
Placido Neri
Keyword(s):  
Multidimensional Nmr ◽  
Nmr Studies

Multidimensional NMR studies of immunosuppressants and their binding proteins

1993 ◽  
pp. 215-219
Author(s):  
Stephen Fesik ◽  
Andrew Petros ◽  
Timothy Logan ◽  
Liping Yu ◽  
Robert Xu ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Multidimensional Nmr ◽  
Nmr Studies

Multidimensional NMR studies of an exchangeable apolipoprotein and its interactions with lipids

1997 ◽  
pp. 427-438 ◽  
Author(s):  
Jianjun Wang ◽  
Daisy Sahoo ◽  
Dean Schieve ◽  
Stéphane M. Gagné ◽  
Brian D. Sykes ◽  
...  
Keyword(s):  
Multidimensional Nmr ◽  
Nmr Studies ◽  
Exchangeable Apolipoprotein

Multidimensional NMR Studies on Polyurethane-Based Dendritic Wedges

2002 ◽  
pp. 147-165
Author(s):  
Minghui Chai ◽  
Peter L. Rinaldi ◽  
Uraiwan Puapaiboon ◽  
Richard T. Taylor
Keyword(s):  
Multidimensional Nmr ◽  
Nmr Studies

Multidimensional NMR Studies of Poly(ethylene-co-1-butene) Microstructures

2003 ◽  
Vol 36 (11) ◽  
pp. 4017-4028 ◽  
Author(s):  
Sangrama K. Sahoo ◽  
Tong Zhang ◽  
D. Venkat Reddy ◽  
Peter L. Rinaldi ◽  
Lester H. McIntosh ◽  
...  
Keyword(s):  
Multidimensional Nmr ◽  
Nmr Studies ◽  
Poly Ethylene

The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function

2017 ◽  
Vol 398 (5-6) ◽  
pp. 577-588 ◽  
Author(s):  
Miriam Schöpel ◽  
Veena Nambiar Potheraveedu ◽  
Thuraya Al-Harthy ◽  
Raid Abdel-Jalil ◽  
Rolf Heumann ◽  
...  
Keyword(s):  
Sequence Similarity ◽  
Point Mutations ◽  
Hypervariable Region ◽  
Small Gtpases ◽  
Multidimensional Nmr ◽  
Nucleotide Exchange ◽  
Nmr Studies ◽  
High Sequence Similarity ◽  
And Function ◽  
Gtpase Cycle

Abstract Ras GTPases are key players in cellular signalling because they act as binary switches. These states manifest through toggling between an active (GTP-loaded) and an inactive (GDP-loaded) form. The hydrolysis and replenishing of GTP is controlled by two additional protein classes: GAP (GTPase-activating)- and GEF (Guanine nucleotide exchange factors)-proteins. The complex interplay of the proteins is known as the GTPase-cycle. Several point mutations of the Ras protein deregulate this cycle. Mutations in Ras are associated with up to one-third of human cancers. The three isoforms of Ras (H, N, K) exhibit high sequence similarity and mainly differ in a region called HVR (hypervariable region). The HVR governs the differential action and cellular distribution of the three isoforms. Rheb is a Ras-like GTPase that is conserved from yeast to mammals. Rheb is mainly involved in activation of cell growth through stimulation of mTORC1 activity. In this review, we summarise multidimensional NMR studies on Rheb and Ras carried out to characterise their structure-function relationship and explain how the activity of these small GTPases can be modulated by low molecular weight compounds. These might help to design GTPase-selective antagonists for treatment of cancer and brain disease.

NMR studies of the R2 repeat and related peptide fragments of the DNA binding domain of c-Myb. New light on the structure and folding of R2.

1999 ◽  
Vol 96 (9/10) ◽  
pp. 1580-1584 ◽  
Author(s):  
I. Ségalas ◽  
S. Desjardins ◽  
H. Oulyadi ◽  
Y. Prigent ◽  
S. Tribouillard ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Peptide Fragments ◽  
Nmr Studies ◽  
Related Peptide
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