High-dose ursodeoxycholic acid in the treatment of primary sclerosing cholangitis

2007 ◽  
pp. 238-250
Author(s):  
R. W. Chapman
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
High Dose

scholarly journals Primary sclerosing cholangitis and pregnancy

2011 ◽  
Vol 1 (3) ◽  
pp. 55 ◽  
Author(s):  
Casper Q. Kammeijer ◽  
Robert A. De Man ◽  
Christianne J.M. De Groot
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Rare Case ◽  
Progressive Disease ◽  
High Dose ◽  
Term Outcome ◽  
Long Term Outcome ◽  
In Pregnancy

Primary sclerosing cholangitis is a progressive disease, and coincidentally in pregnancy it is rare. It is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure. A rare case of primary sclerosing cholangitis in pregnancy is presented. The course of the pregnancy was marked by threatened preterm delivery and exacerbation of cholestasis. She was successfully treated with ursodeoxycholic acid (UDCA). Although, primary sclerosing cholangitis has both maternal and fetal effects on pregnancy, the overall outcome is favorable. Only few cases have been reported using high dose ursodeoxycholic acid for primary sclerosing cholangitis in pregnancy, it often improves pruritus but has no protection against stillbirth. Data on the safety to the fetus or neonate and long-term outcome are scarce.

scholarly journals High dose ursodeoxycholic acid in primary sclerosing cholangitis does not prevent colorectal neoplasia

2012 ◽  
Vol 35 (4) ◽  
pp. 451-457 ◽  
Author(s):  
L. Lindström ◽  
K. M. Boberg ◽  
O. Wikman ◽  
I. Friis-Liby ◽  
R. Hultcrantz ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Colorectal Neoplasia ◽  
High Dose

High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis

2001 ◽  
Vol 96 (5) ◽  
pp. 1558-1562 ◽  
Author(s):  
Denise M. Harnois ◽  
Paul Angulo ◽  
Roberta A. Jorgensen ◽  
Nicholas F. LaRusso ◽  
Keith D. Lindor
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
High Dose

scholarly journals Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression

Hepatology ◽  
2010 ◽  
Vol 52 (1) ◽  
pp. 197-203 ◽  
Author(s):  
Emmanouil Sinakos ◽  
Hanns-Ulrich Marschall ◽  
Kris V. Kowdley ◽  
Alex Befeler ◽  
Jill Keach ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Disease Progression ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Acid Treatment ◽  
High Dose
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