scholarly journals High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

2011 ◽  
Vol 106 (9) ◽  
pp. 1638-1645 ◽  
Author(s):  
John E Eaton ◽  
Marina G Silveira ◽  
Darrell S Pardi ◽  
Emmanouil Sinakos ◽  
Kris V Kowdley ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Colorectal Neoplasia ◽  
High Dose

scholarly journals High dose ursodeoxycholic acid in primary sclerosing cholangitis does not prevent colorectal neoplasia

2012 ◽  
Vol 35 (4) ◽  
pp. 451-457 ◽  
Author(s):  
L. Lindström ◽  
K. M. Boberg ◽  
O. Wikman ◽  
I. Friis-Liby ◽  
R. Hultcrantz ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Colorectal Neoplasia ◽  
High Dose

Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: A meta-analysis

2002 ◽  
Vol 56 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Roy M. Soetikno ◽  
Otto S. Lin ◽  
Paul A. Heidenreich ◽  
Harvey S. Young ◽  
Michael O. Blackstone
Keyword(s):  
Ulcerative Colitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Colorectal Neoplasia ◽  
Meta Analysis ◽  
Increased Risk

scholarly journals Primary sclerosing cholangitis and pregnancy

2011 ◽  
Vol 1 (3) ◽  
pp. 55 ◽  
Author(s):  
Casper Q. Kammeijer ◽  
Robert A. De Man ◽  
Christianne J.M. De Groot
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Rare Case ◽  
Progressive Disease ◽  
High Dose ◽  
Term Outcome ◽  
Long Term Outcome ◽  
In Pregnancy

Primary sclerosing cholangitis is a progressive disease, and coincidentally in pregnancy it is rare. It is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure. A rare case of primary sclerosing cholangitis in pregnancy is presented. The course of the pregnancy was marked by threatened preterm delivery and exacerbation of cholestasis. She was successfully treated with ursodeoxycholic acid (UDCA). Although, primary sclerosing cholangitis has both maternal and fetal effects on pregnancy, the overall outcome is favorable. Only few cases have been reported using high dose ursodeoxycholic acid for primary sclerosing cholangitis in pregnancy, it often improves pruritus but has no protection against stillbirth. Data on the safety to the fetus or neonate and long-term outcome are scarce.

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