The Hair Follicle Stem Cell as the Paradigm Multipotent Adult Stem Cell

2008 ◽  
pp. 275-287 ◽  
Author(s):  
Robert M. Hoffman
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Adult Stem Cell ◽  
Hair Follicle Stem Cell

scholarly journals Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis

2021 ◽  
Vol 9 ◽  
Author(s):  
Bojie Lin ◽  
Jiangying Zhu ◽  
Guoqian Yin ◽  
Mingde Liao ◽  
Guanyu Lin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Hair Follicle ◽  
Promoter Region ◽  
Cell Function ◽  
Adult Stem Cell ◽  
Stem Cell Differentiation ◽  
Model Systems ◽  
Hair Follicle Stem Cell

IntroductionAdult stem cell function has been one of the most intensively explored areas of biological and biomedical research, with hair follicle stem cells serving as one of the best model systems. This study explored the role of the transcription factor DLX5 in regulating hair follicle stem cell (HFSC) differentiation.MethodsHFSCs were isolated, characterized, and assessed for their expression of DLX5, c-MYC, NSD1, and miR-29c-3p using RT-qPCR, Western blot analysis, or immunofluorescence. Next, the ability of HFSCs to proliferate as well as differentiate into either sebaceous gland cells or epidermal cells was determined. The binding of DLX5 to the c-MYC promoter region, the binding of c-MYC to the miR-29c-3p promoter region, and the binding of miR-29c-3p to the 3′-UTR of NSD1 mRNA were verified by luciferase activity assay and ChIP experiments.ResultsDLX5 was highly expressed in differentiated HFSCs. DLX5 transcriptionally activated c-MYC expression to induce HFSC differentiation. c-MYC was able to bind the miR-29c-3p promoter and thus suppressed its expression. Without miR-29c-3p mediated suppression, NSD1 was then able to promote HFSC differentiation. These in vitro experiments suggested that DLX5 could promote HFSC differentiation via the regulation of the c-MYC/miR-29c-3p/NSD1 axis.DiscussionThis study demonstrates that DLX5 promotes HFSC differentiation by modulating the c-MYC/miR-29c-3p/NSD1 axis and identifies a new mechanism regulating HFSC differentiation.

Defining the hair follicle stem cell (Part II)

2009 ◽  
Vol 36 (10) ◽  
pp. 1134-1137 ◽  
Author(s):  
Peggy Myung ◽  
Thomas Andl ◽  
Mayumi Ito
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hair Follicle Stem Cell

BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation

2017 ◽  
Vol 86 (2) ◽  
pp. e60 ◽  
Author(s):  
Carlos Clavel ◽  
Delia Quek ◽  
Jamien Lim ◽  
Shuan Yong Teo
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Hair Growth ◽  
Stem Cell Niche ◽  
Skin Pigmentation ◽  
Bmp Signaling ◽  
Hair Follicle Stem Cell ◽  
Cell Niche

scholarly journals Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

2019 ◽  
Vol 38 (19) ◽  
Author(s):  
Daniel Peña‐Jimenez ◽  
Silvia Fontenete ◽  
Diego Megias ◽  
Coral Fustero‐Torre ◽  
Osvaldo Graña‐Castro ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Stem Cell Niche ◽  
Lymphatic Vessels ◽  
Skin Regeneration ◽  
Hair Follicle Stem Cell ◽  
Cell Niche
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