Role of side-chain amidation for the anticholestatic action of nourursodeoxycholic acid in rat liver

2009 ◽  
pp. 163-165
Author(s):  
S. Maitz ◽  
G. U. Denk ◽  
R. Wimmer ◽  
C. Rust ◽  
P. Invernizzi ◽  
...  
Keyword(s):  
Rat Liver ◽  
Side Chain

METABOLISM OF 17α-HYDROXYPROGESTERONE-4-14C-17α-CAPROATE BY HOMOGENATES OF RAT LIVER AND HUMAN PLACENTA

1961 ◽  
Vol 36 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Margaret Wiener ◽  
Charles I. Lupa ◽  
E. Jürgen Plotz
Keyword(s):  
Rat Liver ◽  
Human Placenta ◽  
Steric Hindrance ◽  
Placental Tissue ◽  
Caproic Acid ◽  
Major Product ◽  
Side Chain ◽  
Anaerobic Conditions ◽  
Prolonged Action ◽  
Long Acting

ABSTRACT 17α-hydroxyprogesterone-4-14C-17α-caproate (HPC), a long-acting progestational agent, was incubated with homogenates of rat liver and human placenta. The rat liver was found to reduce Ring A of HPC under anaerobic conditions to form allopregnane-3β,17α-diol-20-one-17α-caproate and pregnane-3β,17α-diol-20-one-17α-caproate, the allopregnane isomer being the major product. The caproic acid ester was neither removed nor altered during the incubation. Placental tissue did not attack HPC under conditions where the 20-ketone of progesterone was reduced. It is postulated that this absence of attack on the side chain is due to steric hindrance from the caproate ester, and that this may account for the prolonged action of HPC.

Role of nitric oxide in hepatic and pulmonary injury following ischemia-reperfusion of rat liver

2003 ◽  
Vol 124 (4) ◽  
pp. A719-A720
Author(s):  
Yuji Takamatsu ◽  
Kazuo Shimada ◽  
Koji Yamaguchi ◽  
Kazuo Chijiiwa ◽  
Masao Tanaka
Keyword(s):  
Nitric Oxide ◽  
Rat Liver ◽  
Ischemia Reperfusion ◽  
Pulmonary Injury

scholarly journals Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 ◽  
Vol 35 (4) ◽  
pp. 709-720
Author(s):  
S Shafi ◽  
S E Brady ◽  
A Bensadoun ◽  
R J Havel
Keyword(s):  
Rat Liver ◽  
Hepatic Lipase ◽  
Chylomicron Remnants
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