Discriminative Stimulus- vs. Conditioned Reinforcer-Induced Reinstatement of Drug-Seeking Behavior and arc mRNA Expression in Dorsolateral Striatum

2009 ◽  
pp. 269-284 ◽  
Author(s):  
Matthew D. Riedy ◽  
Raymond P. Kesner ◽  
Glen R. Hanson ◽  
Kristen A. Keefe
Keyword(s):  
Mrna Expression ◽  
Discriminative Stimulus ◽  
Conditioned Reinforcer ◽  
Drug Seeking ◽  
Dorsolateral Striatum ◽  
Seeking Behavior

Differences Between Accumbens Core and Shell Neurons Exhibiting Phasic Firing Patterns Related to Drug-Seeking Behavior During a Discriminative-Stimulus Task

2004 ◽  
Vol 92 (3) ◽  
pp. 1608-1614 ◽  
Author(s):  
Udi E. Ghitza ◽  
Anthony T. Fabbricatore ◽  
Volodymyr F. Prokopenko ◽  
Mark O. West
Keyword(s):  
Discriminative Stimulus ◽  
Lever Press ◽  
Physiological Activity ◽  
Neuronal Firing ◽  
Differential Distribution ◽  
Drug Seeking ◽  
Firing Patterns ◽  
Single Lever ◽  
Seeking Behavior ◽  
Intertone Interval

The habit-forming effects of abused drugs depend on the mesocorticolimbic dopamine system innervating the nucleus accumbens (NAcc). To examine whether different NAcc subterritories (core and medial shell) exhibit a differential distribution of neurons showing phasic firing patterns correlated with drug-seeking behavior, rats were trained to self-administer cocaine, and activity of single NAcc neurons was recorded. In the presence of a discriminative-stimulus (SD) tone, a single lever press produced an intravenous infusion of cocaine (0.35 mg/kg), terminated the tone, and started an intertone interval ranging from 3 to 6 min. Lever presses during this intertone interval had no programmed consequences. In addition to evaluating neuronal firing patterns associated with cocaine-reinforced presses, we also evaluated firing patterns associated with unreinforced lever presses to allow interpretation of firing free of factors other than the instrumental response (such as tone-off and onset of the pump signaling drug infusion). Core neurons exhibited a greater change in firing than medial shell neurons both in the seconds preceding the reinforced and unreinforced lever press response and in the seconds following the unreinforced response. Core and medial shell neurons exhibited similar changes in firing during the seconds following the cocaine-reinforced press. The differential distribution of neurons exhibiting phasic changes in firing preceding the lever press suggests that the physiological activity of core neurons may play a greater role than that of medial shell neurons in processes related to the execution of conditioned drug-seeking responses.

Care plans reduce ED visits in those with drug-seeking behavior

2015 ◽  
Vol 33 (12) ◽  
pp. 1799-1801 ◽  
Author(s):  
Frederick Fiesseler ◽  
Renee Riggs ◽  
David Salo ◽  
Richard Klemm ◽  
Ashley Flannery ◽  
...  
Keyword(s):  
Drug Seeking ◽  
Care Plans ◽  
Seeking Behavior ◽  
Ed Visits

Effects of buprenorphine sublingual tablet maintenance on opioid drug-seeking behavior by humans

2002 ◽  
Vol 160 (4) ◽  
pp. 344-352 ◽  
Author(s):  
Mark K. Greenwald ◽  
Kory J. Schuh ◽  
John A. Hopper ◽  
Charles R. Schuster ◽  
Chris-Ellyn Johanson
Keyword(s):  
Drug Seeking ◽  
Sublingual Tablet ◽  
Seeking Behavior

Impulsivity and Drug-Seeking Behavior in Substance Misuse

2020 ◽  
pp. 65-86
Author(s):  
Noelle C. Anastasio ◽  
Dennis J. Sholler ◽  
Brionna D. Davis-Reyes ◽  
Amanda E. Price ◽  
Michelle A. Land ◽  
...  
Keyword(s):  
Substance Use ◽  
Cue Reactivity ◽  
Complex Nature ◽  
Psychoactive Drugs ◽  
Negative Consequences ◽  
Drug Seeking ◽  
Drug Cues ◽  
Seeking Behavior ◽  
The Impact ◽  
Substances Of Abuse

Vulnerability to initiate use of psychoactive drugs as well as relapse to drug-seeking in patients with established substance use disorders are precipitated by behavioral disinhibition or impulsivity (a predisposition toward rapid unplanned reactions to stimuli without regard to negative consequences) and attentional bias toward drug cues (cue reactivity). These behavioral phenotypes are not independent mechanistically nor neurobiologically, and preclinical analyses have demonstrated the complex nature of the interactions between these interlocked phenotypic behaviors, including aspects of their shared neurobiology and circuitry. This chapter focuses on impulsivity and drug-seeking behaviors from a preclinical perspective and summarizes studies exploring the impact of substances of abuse in the context of the neurobiology of impulsivity and drug-seeking behaviors in rodents.

scholarly journals Correction to: Role of adolescent-formed, context-drug-associations on reinstatement of drug-seeking behavior in rats

2020 ◽  
Vol 237 (11) ◽  
pp. 3505-3506
Author(s):  
Bo Ram Cho ◽  
Jennifer Gerena ◽  
Doris I. Olekanma ◽  
Aneesh Bal ◽  
André N. Herrera Charpentier ◽  
...  
Keyword(s):  
Drug Seeking ◽  
Seeking Behavior

scholarly journals A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior

2020 ◽  
Vol 102 ◽  
pp. 109961 ◽  
Author(s):  
Katherine E. Larrimore ◽  
Latha Kannan ◽  
R. Player Kendle ◽  
Tameem Jamal ◽  
Matthew Barcus ◽  
...  
Keyword(s):  
Drug Seeking ◽  
Seeking Behavior

Compulsive Drug-Seeking Behavior and Relapse

2006 ◽  
Vol 937 (1) ◽  
pp. 1-26 ◽  
Author(s):  
FRIEDBERT WEISS ◽  
ROBERTO CICCOCIOPPO ◽  
LOREN H. PARSONS ◽  
SIMON KATNER ◽  
XIU LIU ◽  
...  
Keyword(s):  
Drug Seeking ◽  
Seeking Behavior
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