Conditioned reinstatement of drug-seeking behavior with a discrete compound stimulus classically conditioned with intravenous cocaine.

2001 ◽  
Vol 115 (5) ◽  
pp. 1086-1092 ◽  
Author(s):  
Paul J. Kruzich ◽  
Kimberly M. Congelton ◽  
Ronald E. See
2004 ◽  
Vol 91 (1) ◽  
pp. 314-323 ◽  
Author(s):  
Laura L. Peoples ◽  
Kevin G. Lynch ◽  
Jamie Lesnock ◽  
Nidhi Gangadhar

During a chronic extracellular recording session, animals with a history of cocaine self-administration were allowed to initiate drug seeking under drug-free conditions. Later, in the same recording session, animals engaged in intravenous cocaine self-administration. During the drug-free period, 31% of 70 accumbal neurons showed a significant increase in average firing rate in association with either or both the exposure to cues that signaled the onset of cocaine availability and the subsequent onset of drug-seeking behavior. The neurons that showed an average excitatory response during the drug-free period were the only group of neurons that showed an average excitatory phasic response to cocaine-reinforced lever presses during the drug self-administration session. A majority of the neurons that were activated during the drug-free period, like the majority of other neurons, showed decreases in average firing in response to self-administered cocaine. However, the neurons that were activated during the drug-free period maintained a higher rate of firing throughout the self-administration session than did other accumbal neurons. The data of the present study are consistent with the conclusion that accumbal neurons contribute to, or otherwise process, initiation of drug seeking under drug-free conditions and that they do so via primarily excitatory responses. Furthermore, there is continuity between the drug-free and -exposed conditions in neural responses associated with drug seeking. Finally, the data have potential implications for understanding mechanisms that transduce accumbal-mediated drug effects that contribute to drug addiction.


2015 ◽  
Vol 33 (12) ◽  
pp. 1799-1801 ◽  
Author(s):  
Frederick Fiesseler ◽  
Renee Riggs ◽  
David Salo ◽  
Richard Klemm ◽  
Ashley Flannery ◽  
...  

2002 ◽  
Vol 160 (4) ◽  
pp. 344-352 ◽  
Author(s):  
Mark K. Greenwald ◽  
Kory J. Schuh ◽  
John A. Hopper ◽  
Charles R. Schuster ◽  
Chris-Ellyn Johanson

2020 ◽  
pp. 65-86
Author(s):  
Noelle C. Anastasio ◽  
Dennis J. Sholler ◽  
Brionna D. Davis-Reyes ◽  
Amanda E. Price ◽  
Michelle A. Land ◽  
...  

Vulnerability to initiate use of psychoactive drugs as well as relapse to drug-seeking in patients with established substance use disorders are precipitated by behavioral disinhibition or impulsivity (a predisposition toward rapid unplanned reactions to stimuli without regard to negative consequences) and attentional bias toward drug cues (cue reactivity). These behavioral phenotypes are not independent mechanistically nor neurobiologically, and preclinical analyses have demonstrated the complex nature of the interactions between these interlocked phenotypic behaviors, including aspects of their shared neurobiology and circuitry. This chapter focuses on impulsivity and drug-seeking behaviors from a preclinical perspective and summarizes studies exploring the impact of substances of abuse in the context of the neurobiology of impulsivity and drug-seeking behaviors in rodents.


2020 ◽  
Vol 237 (11) ◽  
pp. 3505-3506
Author(s):  
Bo Ram Cho ◽  
Jennifer Gerena ◽  
Doris I. Olekanma ◽  
Aneesh Bal ◽  
André N. Herrera Charpentier ◽  
...  

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