Delayed Neuronal Death Following Acute Focal Brain Ischemia

2003 ◽  
pp. 101-102
Author(s):  
Eugene Gusev ◽  
Veronica I. Skvortsova
Keyword(s):  
Brain Ischemia ◽  
Neuronal Death ◽  
Delayed Neuronal Death ◽  
Focal Brain Ischemia

scholarly journals Phagocytosis executes delayed neuronal death after focal brain ischemia

2013 ◽  
Vol 110 (43) ◽  
pp. E4098-E4107 ◽  
Author(s):  
J. J. Neher ◽  
J. V. Emmrich ◽  
M. Fricker ◽  
P. K. Mander ◽  
C. Thery ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Neuronal Death ◽  
Delayed Neuronal Death ◽  
Focal Brain Ischemia

scholarly journals Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia

2006 ◽  
Vol 98 (1) ◽  
pp. 310-320 ◽  
Author(s):  
Norifumi Shioda ◽  
Shigeki Moriguchi ◽  
Yasufumi Shirasaki ◽  
Kohji Fukunaga
Keyword(s):  
Mouse Brain ◽  
Brain Ischemia ◽  
Neuronal Death ◽  
Delayed Neuronal Death ◽  
Constitutively Active

scholarly journals Protein Aggregation after Focal Brain Ischemia and Reperfusion

2001 ◽  
Vol 21 (7) ◽  
pp. 865-875 ◽  
Author(s):  
Bing-Ren Hu ◽  
Shorena Janelidze ◽  
Myron D. Ginsberg ◽  
Raul Busto ◽  
Miguel Perez-Pinzon ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Protein Aggregation ◽  
Brain Ischemia ◽  
Neuronal Death ◽  
Laser Scanning ◽  
Protein Aggregates ◽  
Laser Scanning Confocal Microscopy ◽  
Artery Occlusion ◽  
Western Blots ◽  
Focal Brain Ischemia

Two hours of transient focal brain ischemia causes acute neuronal death in the striatal core region and a somewhat more delayed type of neuronal death in neocortex. The objective of the current study was to investigate protein aggregation and neuronal death after focal brain ischemia in rats. Brain ischemia was induced by 2 hours of middle cerebral artery occlusion. Protein aggregation was analyzed by electron microscopy, laser-scanning confocal microscopy, and Western blotting. Two hours of focal brain ischemia induced protein aggregation in ischemic neocortical neurons at 1 hour of reperfusion, and protein aggregation persisted until neuronal death at 24 hours of reperfusion. Protein aggregates were found in the neuronal soma, dendrites, and axons, and they were associated with intracellular membranous structures during the postischemic phase. High-resolution confocal microscopy showed that clumped protein aggregates surrounding nuclei and along dendrites were formed after brain ischemia. On Western blots, ubiquitinated proteins (ubi-proteins) were dramatically increased in neocortical tissues in the postischemic phase. The ubi-proteins were Triton-insoluble, indicating that they might be irreversibly aggregated. The formation of ubi-protein aggregates after ischemia correlated well with the observed decrease in free ubiquitin and neuronal death. The authors concluded that proteins are severely damaged and aggregated in neurons after focal ischemia. The authors propose that protein damage or aggregation may contribute to ischemic neuronal death.

Erythropoietin prevents nitric oxide and cathepsin-mediated neuronal death in focal brain ischemia

2011 ◽  
Vol 1370 ◽  
pp. 185-193 ◽  
Author(s):  
Hilmi Ozden ◽  
Ramazan Durmaz ◽  
Güngör Kanbak ◽  
Kubilay Uzuner ◽  
Erinc Aral ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Brain Ischemia ◽  
Neuronal Death ◽  
Focal Brain Ischemia

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

2009 ◽  
Vol 12 (10) ◽  
pp. 1300-1307 ◽  
Author(s):  
Hong-Shuo Sun ◽  
Michael F Jackson ◽  
Loren J Martin ◽  
Karen Jansen ◽  
Lucy Teves ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Neuronal Death ◽  
Delayed Neuronal Death
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