The Hair Cell Synapse

2011 ◽  
pp. 43-60 ◽  
Author(s):  
Teresa Nicolson
Keyword(s):  
Hair Cell ◽  
Cell Synapse

scholarly journals Fast Ca 2+ signals at mouse inner hair cell synapse: a role for Ca 2+ ‐induced Ca 2+ release

2002 ◽  
Vol 539 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Helen J. Kennedy ◽  
Robert W. Meech
Keyword(s):  
Hair Cell ◽  
Inner Hair Cell ◽  
Cell Synapse

scholarly journals Ca2+ and Ca2+-Activated K+ Channels That Support and Modulate Transmitter Release at the Olivocochlear Efferent-Inner Hair Cell Synapse

2010 ◽  
Vol 30 (36) ◽  
pp. 12157-12167 ◽  
Author(s):  
J. Zorrilla de San Martin ◽  
S. Pyott ◽  
J. Ballestero ◽  
E. Katz
Keyword(s):  
Hair Cell ◽  
Transmitter Release ◽  
Inner Hair Cell ◽  
K Channels ◽  
Cell Synapse

scholarly journals Synaptic mitochondria regulate hair-cell synapse size and function

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Hiu-tung C Wong ◽  
Qiuxiang Zhang ◽  
Alisha J Beirl ◽  
Ronald S Petralia ◽  
Ya-Xian Wang ◽  
...  
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Direct Application ◽  
Structural Protein ◽  
Ribbon Synapses ◽  
Presynaptic Function ◽  
Sensory Hair Cells ◽  
Synaptic Mitochondria ◽  
And Function ◽  
Cell Synapse

Sensory hair cells in the ear utilize specialized ribbon synapses. These synapses are defined by electron-dense presynaptic structures called ribbons, composed primarily of the structural protein Ribeye. Previous work has shown that voltage-gated influx of Ca2+ through CaV1.3 channels is critical for hair-cell synapse function and can impede ribbon formation. We show that in mature zebrafish hair cells, evoked presynaptic-Ca2+ influx through CaV1.3 channels initiates mitochondrial-Ca2+ (mito-Ca2+) uptake adjacent to ribbons. Block of mito-Ca2+ uptake in mature cells depresses presynaptic-Ca2+ influx and impacts synapse integrity. In developing zebrafish hair cells, mito-Ca2+ uptake coincides with spontaneous rises in presynaptic-Ca2+ influx. Spontaneous mito-Ca2+ loading lowers cellular NAD+/NADH redox and downregulates ribbon size. Direct application of NAD+ or NADH increases or decreases ribbon size respectively, possibly acting through the NAD(H)-binding domain on Ribeye. Our results present a mechanism where presynaptic- and mito-Ca2+ couple to confer proper presynaptic function and formation.

Large Releasable Pool of Synaptic Vesicles in Chick Cochlear Hair Cells

2004 ◽  
Vol 91 (6) ◽  
pp. 2422-2428 ◽  
Author(s):  
Marc D. Eisen ◽  
Maria Spassova ◽  
Thomas D. Parsons
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Neurotransmitter Release ◽  
Metabotropic Glutamate Receptors ◽  
Cochlear Hair Cells ◽  
Metabotropic Glutamate ◽  
Cochlear Hair Cell ◽  
Cytoplasmic Vesicles ◽  
Vesicle Pool ◽  
Cell Synapse

Hearing requires the hair cell synapse to maintain notable temporal fidelity (≤1 ms) while sustaining neurotransmitter release for prolonged periods of time (minutes). Here we probed the properties and possible anatomical substrate of prolonged neurotransmitter release by using electrical measures of cell surface area as a proxy for neurotransmitter release to study hair cell exocytosis evoked by repetitive stimuli. We observed marked depression of exocytosis by chick tall hair cells. This exocytic depression cannot be explained by calcium current inactivation, presynaptic autoinhibition by metabotropic glutamate receptors, or postsynaptic receptor desensitization. Rather, cochlear hair cell exocytic depression resulted from the exhaustion of a functional vesicle pool. This releasable vesicle pool is large, totaling approximately 8,000 vesicles, and is nearly 10 times greater than the number of vesicles tethered to synaptic ribbons. Such a large functional pool suggests the recruitment of cytoplasmic vesicles to sustain exocytosis, important for maintaining prolonged, high rates of neural activity needed to encode sound.

scholarly journals Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: Correlations with spontaneous rate

2013 ◽  
Vol 521 (14) ◽  
pp. 3260-3271 ◽  
Author(s):  
Albena Kantardzhieva ◽  
M. Charles Liberman ◽  
William F. Sewell
Keyword(s):  
Quantitative Analysis ◽  
Hair Cell ◽  
Inner Hair Cell ◽  
Spontaneous Rate ◽  
Cell Synapse

scholarly journals The efferent medial olivocochlear-hair cell synapse

2012 ◽  
Vol 106 (1-2) ◽  
pp. 47-56 ◽  
Author(s):  
Ana Belén Elgoyhen ◽  
Eleonora Katz
Keyword(s):  
Hair Cell ◽  
Medial Olivocochlear ◽  
Cell Synapse

Transmission at the hair cell synapse

2002 ◽  
Vol 5 (2) ◽  
pp. 85-86 ◽  
Author(s):  
Laurence O. Trussell
Keyword(s):  
Hair Cell ◽  
Cell Synapse
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