scholarly journals Quantitative analysis of ribbons, vesicles, and cisterns at the cat inner hair cell synapse: Correlations with spontaneous rate

2013 ◽  
Vol 521 (14) ◽  
pp. 3260-3271 ◽  
Author(s):  
Albena Kantardzhieva ◽  
M. Charles Liberman ◽  
William F. Sewell
Keyword(s):  
Quantitative Analysis ◽  
Hair Cell ◽  
Inner Hair Cell ◽  
Spontaneous Rate ◽  
Cell Synapse

scholarly journals Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse

2019 ◽  
pp. 2746-18 ◽  
Author(s):  
Graciela Kearney ◽  
Javier Zorrilla de San Martín ◽  
Lucas G. Vattino ◽  
Ana Belén Elgoyhen ◽  
Carolina Wedemeyer ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Hair Cell ◽  
Synaptic Changes ◽  
Cell Synapse

scholarly journals Sensory transduction is required for normal development and maturation ofcochlear inner hair cell synapses

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
John Lee ◽  
Kosuke Kosuke Kawai ◽  
Jeffrey R Holt ◽  
Gwenaelle Geleoc
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Synapse Formation ◽  
Sensory Transduction ◽  
Recessive Mutation ◽  
Inner Hair Cell ◽  
Auditory Hair Cells ◽  
Transmembrane Channel ◽  
Cell Synapse ◽  
Insight Into

Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as synaptopathy. These insults may also damage hair bundles and the sensory transduction apparatus in auditory hair cells. However, a connection between sensory transduction and synaptopathy has not been established. To evaluate potential contributions of sensory transduction to synapse formation and development, we assessed inner hair cell synapses in several genetic models of dysfunctional sensory transduction, including mice lacking Transmembrane Channel-like (Tmc) 1, Tmc2 or both, in Beethoven mice which carry a dominant Tmc1 mutation and in Spinner mice which carry a recessive mutation in Transmembrane inner ear (Tmie). Our analyses reveal loss of synapses in the absence of sensory transduction and preservation of synapses in Tmc1-null mice following restoration of sensory transduction via Tmc1 gene therapy. These results provide insight into the requirement of sensory transduction for hair cell synapse development and maturation.

Transfer characteristic of the inner hair cell synapse: Steady‐state analysis

1994 ◽  
Vol 95 (6) ◽  
pp. 3430-3434 ◽  
Author(s):  
Mark Zagaeski ◽  
Alan R. Cody ◽  
Ian J. Russell ◽  
David C. Mountain
Keyword(s):  
Steady State ◽  
Hair Cell ◽  
Transfer Characteristic ◽  
Inner Hair Cell ◽  
Steady State Analysis ◽  
Cell Synapse ◽  
State Analysis
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