Mechanisms of resistance to cisplatin and alkylating agents

1989 ◽  
pp. 151-169 ◽  
Author(s):  
Thomas C. Hamilton ◽  
Gi-Ming Lai ◽  
Mace L. Rothenberg ◽  
Antonio T. Fojo ◽  
Robert C. Young ◽  
...  
Keyword(s):  
Alkylating Agents ◽  
Mechanisms Of Resistance

Enzymatic mechanisms of resistance to alkylating agents in tumor cells and normal tissues

1988 ◽  
Vol 27 ◽  
pp. 193-198 ◽  
Author(s):  
Michael Colvin ◽  
James E. Russo ◽  
John Hilton ◽  
Deanne M. Dulik ◽  
Catherine Fenselau
Keyword(s):  
Tumor Cells ◽  
Alkylating Agents ◽  
Mechanisms Of Resistance ◽  
Normal Tissues ◽  
Enzymatic Mechanisms

Mechanisms of Resistance to Alkylating Agents

1996 ◽  
pp. 65-81 ◽  
Author(s):  
Philip G. Penketh ◽  
Krishnamurthy Shyam ◽  
Alan C. Sartorelli
Keyword(s):  
Alkylating Agents ◽  
Mechanisms Of Resistance

Molecular mechanisms of resistance to anti-angiogenic drugs

2020 ◽  
Author(s):  
Arianna Filippelli ◽  
Valerio Ciccone ◽  
Sandra Donnini ◽  
Lucia Morbidelli
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Resistance

Photocatalytic Alkylation of Pyrroles and Indoles with α-Diazo Esters

2019 ◽  
Author(s):  
Łukasz Ciszewski ◽  
Jakub Durka ◽  
Dorota Gryko
Keyword(s):  
Aromatic Compounds ◽  
Reaction Pathway ◽  
Alkylating Agents ◽  
Catalytic Amount ◽  
Radical Formation ◽  
Reaction Selectivity ◽  
Diazo Esters ◽  
Electron Withdrawing Substituents

This article describes direct photoalkylation of electron-rich aromatic compounds with diazo compoiunds. C-2 alkylated indoles and pyrroles are obtained with good yields even though the photocatalyst (Ru(bpy)3Cl2) loading is as low as 0.075 mol %. For substrates bearing electron-withdrawing substituents the addition of a catalytic amount of N,N-dimethyl-4-methoxyaniline is required. Both EWG-EWG and EWG-EDG substituted diazo esters are suitable as alkylating agents. The reaction selectivity and mechanistic experiments suggest that carbenes/carbenoid intermediates are not involved in the reaction pathway, instead radical formation is proposed.

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