Clinical Use of Interferons in the Treatment of Malignant Brain Tumors

1988 ◽  
pp. 183-194 ◽  
Author(s):  
M. Nagai
Keyword(s):  
Brain Tumors ◽  
Clinical Use ◽  
Malignant Brain Tumors

Deleted in Malignant Brain Tumors 1 (DMBT1) is differentially expressed in cholangiocarcinogenesis and shows influence on patient survival

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
B Goeppert ◽  
L Frauenschuh ◽  
M Zucknick ◽  
S Roessler ◽  
A Stenzinger ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Patient Survival ◽  
Differentially Expressed ◽  
Malignant Brain Tumors

LOCAL HYPERTHERMIA IN TREATMENT FOR MALIGNANT BRAIN TUMORS

2018 ◽  
Vol 64 (1) ◽  
pp. 54-61
Author(s):  
A. Ryabova ◽  
O. Gribova ◽  
V. Novikov ◽  
E. Choinzonov ◽  
Zh. Starceva ◽  
...  
Keyword(s):  
Experimental Data ◽  
Radiation Therapy ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Combined Treatment ◽  
Complex Treatment ◽  
Local Hyperthermia ◽  
Malignant Brain Tumors ◽  
Sensitizing Effect ◽  
Methods Of Treatment

Unsatisfactory results of complex treatment for malignant brain tumors stimulate search of new effective methods of treatment. Radiation therapy is an integral part of the combined treatment but often does not influence lethally on resistant tumor cells. Thereby in recent decades there has been an active search for different modifiers, which can increase the sensitivity of tumors to chemotherapy and radiotherapy. One of the universal sensitizers is the local hyperthermia. Experimental data showed that the effect of high temperatures had both a direct damaging effect on tumor cells and a sensitizing effect. The literature review given in the article provides an overview of the existing methods of the local hyperthermia for brain tumors treatment.

scholarly journals The Challenge of Diagnosing Constitutional Mismatch Repair Deficiency Syndrome in Brain Malignancies from Young Individuals

2021 ◽  
Vol 22 (9) ◽  
pp. 4629
Author(s):  
Cristina Carrato ◽  
Carolina Sanz ◽  
Ana María Muñoz-Mármol ◽  
Ignacio Blanco ◽  
Marta Pineda ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Mismatch Repair ◽  
Rare Event ◽  
Deficiency Syndrome ◽  
Mismatch Repair Deficiency ◽  
Malignant Brain Tumors ◽  
Repair Deficiency ◽  
Clinical Awareness ◽  
High Degree ◽  
Constitutional Mismatch Repair Deficiency

Biallelic germline mismatch repair (MMR) gene (MLH1, MSH2, MSH6, and PMS2) mutations are an extremely rare event that causes constitutional mismatch repair deficiency (CMMRD) syndrome. CMMRD is underdiagnosed and often debuts with pediatric malignant brain tumors. A high degree of clinical awareness of the CMMRD phenotype is needed to identify new cases. Immunohistochemical (IHC) assessment of MMR protein expression and analysis of microsatellite instability (MSI) are the first tools with which to initiate the study of this syndrome in solid malignancies. MMR IHC shows a hallmark pattern with absence of staining in both neoplastic and non-neoplastic cells for the biallelic mutated gene. However, MSI often fails in brain malignancies. The aim of this report is to draw attention to the peculiar IHC profile that characterizes CMMRD syndrome and to review the difficulties in reaching an accurate diagnosis by describing the case of two siblings with biallelic MSH6 germline mutations and brain tumors. Given the difficulties involved in early diagnosis of CMMRD we propose the use of the IHC of MMR proteins in all malignant brain tumors diagnosed in individuals younger than 25 years-old to facilitate the diagnosis of CMMRD and to select those neoplasms that will benefit from immunotherapy treatment.

scholarly journals Cytogenetic landscape of paired neurospheres and traditional monolayer cultures in pediatric malignant brain tumors

2014 ◽  
Vol 17 (7) ◽  
pp. 965-977 ◽  
Author(s):  
Xiumei Zhao ◽  
Yi-Jue Zhao ◽  
Qi Lin ◽  
Litian Yu ◽  
Zhigang Liu ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Malignant Brain Tumors ◽  
Monolayer Cultures

Detection of deleted in malignant brain tumors 1 and runt-related transcription factor 3 gene expressions in bladder carcinoma

2011 ◽  
Vol 39 (4) ◽  
pp. 4691-4695 ◽  
Author(s):  
Yavuz Dodurga ◽  
Çığır Biray Avcı ◽  
N. Lale Satiroglu-Tufan ◽  
Canten Tataroglu ◽  
Zehra Kesen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Brain Tumors ◽  
Bladder Carcinoma ◽  
Gene Expressions ◽  
Malignant Brain Tumors ◽  
Related Transcription Factor ◽  
Transcription Factor 3
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