Quantitative Autoradiography of Drug Binding Sites: Methodological Considerations

1985 ◽  
pp. 397-406
Author(s):  
G. F. Wooten ◽  
W. A. Geary
Keyword(s):  
Binding Sites ◽  
Drug Binding ◽  
Quantitative Autoradiography ◽  
Drug Binding Sites ◽  
Methodological Considerations

scholarly journals Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites

2018 ◽  
Vol 14 ◽  
pp. 155-160 ◽  
Author(s):  
Keishi Yamasaki ◽  
Koji Nishi ◽  
Makoto Anraku ◽  
Kazuaki Taguchi ◽  
Toru Maruyama ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Sites ◽  
Drug Binding ◽  
Drug Binding Sites ◽  
Metal Catalyzed Oxidation ◽  
Metal Catalyzed ◽  
Catalyzed Oxidation

scholarly journals Systematic exploration of multiple drug binding sites

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Mónika Bálint ◽  
Norbert Jeszenői ◽  
István Horváth ◽  
David van der Spoel ◽  
Csaba Hetényi
Keyword(s):  
Binding Sites ◽  
Drug Binding ◽  
Multiple Drug ◽  
Systematic Exploration ◽  
Drug Binding Sites

scholarly journals Footprinting studies on the effect of echinomycin on the structure of a bent DNA fragment

1990 ◽  
Vol 269 (1) ◽  
pp. 217-221 ◽  
Author(s):  
K R Fox ◽  
E Kentebe
Keyword(s):  
Binding Sites ◽  
Dna Structure ◽  
Drug Binding ◽  
Micrococcal Nuclease ◽  
Kinetoplast Dna ◽  
Bent Dna ◽  
Diethyl Pyrocarbonate ◽  
Drug Binding Sites ◽  
Dna Fragment

The interaction of echinomycin with a kinetoplast DNA fragment which contains phased runs of adenine residues has been examined by various footprinting techniques. DNAase I footprinting confirms that all drug-binding sites contain the dinucleotide CpG. However, not all such sequences are protected. Three sites, each of which is located between two adenine tracks in the sequence GCGA, are not protected from DNAase I attack. Enhanced cleavage by DNAase I, DNAase II and micrococcal nuclease is observed in regions surrounding drug-binding sites. The results suggest that echinomycin alters the conformation of the AT tracks, making them more like an average DNA structure. Echinomycin renders adenine residues in the sequence CGA hyper-reactive to diethyl pyrocarbonate.

Mutations in Ebola Not Disrupting Drug Binding Sites—So Far

2015 ◽  
Vol 10 (4) ◽  
pp. 140-141
Author(s):  
David C. Holzman
Keyword(s):  
Binding Sites ◽  
Drug Binding ◽  
Drug Binding Sites

scholarly journals Location of drug binding sites on human serum albumin.

1986 ◽  
Vol 34 (7) ◽  
pp. 2989-2993 ◽  
Author(s):  
KAZUO MARUYAMA ◽  
HIDEO NISHIGORI ◽  
MOTOHARU IWATSURU
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Sites ◽  
Drug Binding ◽  
Drug Binding Sites
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