Inferring Hydraulic Connectivity of Induced Fractures in the Near-wellbore Region Using DAS-recorded Tube Waves Excited by Perforation Shots

We present a novel use of tube waves exited by perforation (or “perf”) shots and recorded on distributed acoustic sensing (DAS) to infer and compare the hydraulic connectivity of induced fractures near the wellbore on a stage-by-stage basis. Evaluating the fracture connectivity near the wellbore is critical since it controls the flow of the hydrocarbons from the formation to the wellbore. Currently, there are no established methods used to assess this property. However, we discuss how tube wave decay rates can be used to infer relative differences in fracture connectivity between stages and, through field observations on DAS, demonstrate the correlation between decay rates and frac effectiveness. Additionally, we consider other potential uses of this data in unconventional wells such as assessing plug integrity and constraining fracture geometry with Krauklis waves. DAS data is commonly acquired during the perf shots but primarily for fiber depth calibration purposes and has not been well studied. Our work illustrates the untapped potential of this data and how it can be easily repurposed to bring new insights about fracture characteristics in the near-wellbore region.

Impact of Using a New High-Resolution Solar Reference Spectrum on OMI Ozone Profile Retrievals

We evaluated a new high-resolution solar reference spectrum for characterizing space-borne Ozone Monitoring Instrument (OMI) measurements as well as for retrieving ozone profile retrievals over the ultraviolet (UV) wavelength range from 270 to 330 nm. The SAO2010 solar reference has been a standard for use in atmospheric trace gas retrievals, which is a composite of ground-based and balloon-based solar measurements from the Kitt Peak National Observatory (KPNO) and Air Force Geophysics Laboratory (AFGL), respectively. The new reference spectrum, called the TSIS-1 Hybrid Solar Reference Spectrum (HSRS), spans 202–2730 nm at a 0.01 to ~0.001 nm spectral resolution. The TSIS-1 HSRS in the UV region of interest in this study is a composite of AFGL and ground-based solar measurements from the Quality Assurance of Spectral Ultraviolet Measurements In Europe (QASUME) campaign, with a radiometric calibration that used the lower resolution Spectral Irradiance Monitor (SIM) instrument on the space-based Total and Spectral Solar Irradiance Sensor-1 (TSIS-1) mission. The TSIS-1 HSRS radiometric uncertainties were below 1% whereas those of SAO2010 ranged from 5% in the longer UV part to 15% in the shorter UV part. In deriving slit functions and wavelength shifts from OMI solar irradiances, the resulting fitting residuals showed significant improvements of 0.5–0.7% (relatively, 20–50%) due to switching from the SAO2010 to the TSIS-1 HSRS. Correspondingly, in performing ozone profile retrievals from OMI radiances, the fitting residuals showed relative improvements of up to ~5% in 312–330 nm with relative differences of 5–7% in the tropospheric layer column ozone; the impact on stratospheric ozone retrievals was negligible.

Evaluation of lithostratigraphic units and groundwater potential using the resolution capacities of two different electrical tomographic electrodes at dual-spacing

The selection of a choice electrode is pertinent to attenuating noise and improving geophysical tomographic inversion results. Besides, the detailed understanding of the geodynamic condition of subsurface formation is crucial to sustainable potable groundwater abstraction. Hence, the subsurface lithostratigraphic units and groundwater potential of two sites (i.e., Site 1 and Site 2) within the Universiti Sains Malaysia were evaluated using borehole-constrained electrical resistivity tomography (ERT) and induced polarisation (IP) tomography. Both methods employed the resolution capacities of stainless-steel and copper electrodes at dual-spacing. The ERT and IP field data and inversion results for copper electrodes were generally robust due to the generated higher positive data points and lower RMS errors, percentage relative differences, and mean absolute percentage errors (MAPE) than the stainless-steel electrodes, especially at Site 1 with a profile length of 200 m and an electrode spacing of 5 m. However, both electrodes tend to produce inversion models with almost the same parameters at Site 2, using half the profile length and electrode spacing of Site 1, i.e., 100 m and 2.5 m, respectively. Thus, the sensitivities and resolution capacities of the tomographic electrodes are heavily influenced by electrode spacing, profile length, amount of injected current, and depth of investigation. The borehole lithostratigraphic units, typically sandy silt, sand, and silty sand, have good correlations with the ERT and IP inversion results. The variability in observed resistivity and chargeability values were due to heterogeneous weathered materials and saturating water fills within the fractured and deeply-weathered granitic bedrock, with <200 Ωm and a chargeability of >1.8 msec. The models' median depth of >40 m mapped for the weathered and/or fractured sections was suggestive of high groundwater-yielding capacity in boreholes to sustain a part of the university community.

World and European Rowing Medallists Pace With Smaller Variation Than Their Competitors

Purpose: To establish the relation between pacing pattern and performance, within sex, and number of crew members, at the very highest performance level in World class rowing.Methods: Pacing profiles based on official 500 m split times in 106 A-finals with six contesting boat crews (n = 636 crews), in recent World (2017–2019) and European (2017–2021) championships, were analyzed. The coefficient of variation (CV) and sum of relative differences (SRD) of the split times, and normalized velocities in the four segments of the race, were compared between performance levels, that is, placement (1st–6th), and subgroups based on sex (female or male) and number of crew members (one, two, or four). Statistical tests and resulting p-values and effect sizes (Cohen's d) were used to assess differences between groups.Results: The pacing profiles of the medallists had smaller variation than those of the non-podium finishers (CV = 1.72% vs. CV = 2.00%; p = 4 × 10−7, d = 0.41). Compared to the non-podium finishers, the medallists had lower normalized velocities in the first and second segments of the race, slightly higher in the third segment and higher in the fourth segment. Female crews paced somewhat more evenly than male crews. No significant differences were found in the evenness of pacing profiles between singles, doubles/pairs and quads/fours. Analyses of SRD were overall consistent with analyses of CV.Conclusion: Medal winners in major rowing championships use a more even pacing strategy than their final competitors, which could imply that such a strategy is advantageous in rowing.

Diminished GAD67 Terminals and Ambient GABA Inhibition Associated with Reduced Motor Neuron Recruitment Threshold in the SOD1G93A ALS mouse

Pre-symptomatic studies in mouse models of the neurodegenerative motor neuron (MN) disease, Amyotrophic Lateral Sclerosis (ALS) highlight early alterations in intrinsic and synaptic excitability and have supported an excitotoxic theory of MN death. However, a role for synaptic inhibition in disease development is not sufficiently explored among other mechanisms. Since inhibition plays a role in both regulating motor output and in neuroprotection, we examined the age-dependent anatomical changes in inhibitory presynaptic terminals on MN cell bodies using fluorescent immunohistochemistry for GAD67 (GABA) and GlyT2 (glycine) presynaptic proteins comparing ALS-vulnerable trigeminal jaw closer (JC) motor pools with the ALS-resistant extraocular (EO) MNs in the SOD1G93A mouse model for ALS. Our results indicate differential patterns of temporal changes of these terminals in vulnerable versus resilient MNs and relative differences between SOD1G93A and wild-type (WT) MNs. Notably, we found pre-symptomatic up-regulation in inhibitory terminals in the EO MNs while the vulnerable JC MNs mostly showed a decrease in inhibitory terminals. Specifically, there was a statistically significant decrease in the GAD67 somatic abuttal in the SOD1G93A JC MNs compared to WT around P12. Using in vitro patch-clamp electrophysiology, we found a parallel decrease in the ambient GABA-dependent tonic inhibition in the SOD1G93A JC MNs. While it is unclear if the two mechanisms are directly related, pharmacological blockade of specific subtype of GABAA-a5 receptors suggests that tonic inhibition can control MN recruitment threshold. Furthermore, reduction in tonic GABA current as observed here in the mutant, identifies a putative molecular mechanism explaining our observations of hyperexcitable shifts in JC MN recruitment threshold in the SOD1G93A mouse. Lastly, we showcase non-parametric resampling-based bootstrap statistics for data analyses, and provide the Python code on GitHub for wider reuse.

Pre- and post-treatment image-based dosimetry in 90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit

Objective: To evaluate the pre-treatment and post-treatment imaging-based dosimetry of patients treated with 90Y-microspheres, including accurate estimations of dose to tumor, healthy liver and lung. To do so, the Monte Carlo (MC) TOPAS platform is in this work extended towards its utilization in radionuclide therapy. Approach: Five patients treated at the Massachusetts General Hospital were selected for this study. All patients had data for both pre-treatment SPECT-CT imaging using 99mTc-MAA as a surrogate of the 90Y-microspheres treatment and SPECT-CT imaging immediately after the 90Y activity administration. Pre- and post-treatment doses were computed with TOPAS using the SPECT images to localize the source positions and the CT images to account for tissue inhomoegeneities. We compared our results with analytical calculations following the voxel-based MIRD scheme. Main results: TOPAS results largely agreed with the MIRD-based calculations in soft tissue regions: the average difference in mean dose to the liver was 0.14 Gy/GBq (2.6%). However, dose distributions in the lung differed considerably: absolute differences in mean doses to the lung ranged from 1.2 Gy/GBq to 6.3 Gy/GBq and relative differences from 153% to 231%. We also found large differences in the intra-hepatic dose distributions between pre- and post-treatment imaging, but only limited differences in the pulmonary dose. Significance: Doses to lung were found to be higher using TOPAS with respect to analytical calculations which may significantly underestimate dose to the lung, suggesting the use of MC methods for 90Y dosimetry. According to our results, pre-treatment imaging may still be representative of dose to lung in these treatments.

Definitive Dynamic MWD Surveys Generate Rig Time Savings and Flat Time Reductions in the Middle East

Wellbore surveying is a critical component of any well construction project. Understanding the position of a well in 3D space allows for the wells geological objectives to be carried out while safely avoiding other wellbores. Wellbore surveys are generally conducted using a magnetically referenced measurement while drilling tool (MWD) and taken while static, either before, after or sometimes during the connection. The drillstring is often worked to release trapped torque and time is often taken waiting for the survey to be pumped up. All of this consumes rig time and opens the wellbore up to wellbore instability issues. The application of definitive dynamic surveys (DDS) which are static MWD quality surveys taken while drilling and updated continuously. There is no longer a need to stop and take a static survey eliminating MWD surveying related rig time, reducing drilling risks from additional pumps off time and improving TVD accuracy and directional control. The rig time taken for surveying with and without DDS will be compared between similar wells in the field, and detailed analysis of relative tortuosity between DDS and non-DDS wells will also be conducted. Trajectory control analysis will be reviewed by looking at the difference in the number of downlinks between DDS and no DDS wells and also the deviation from the planned trajectory. An overall analysis of on bottom ROP will be made and an analysis as to the relative differences in TVD between static and DDS survey will be carried out. This abstract will outline the rig time and operational savings from DDS, it will detail the surveying time savings, directional control improvements, TVD placement differences to static surveys and provide costs savings as a comparison to previous similar wells. This will be outlined over a number of wells, divided by sections as the wells are batch drilled and provide an insight into the benefits of DDS on a drilling campaign. Some discussion will be made as to the efficacy of the DDS surveys and how their error model has been developed. DDS is a unique and novel way of taking surveys while drilling, providing static MWD quality without the added rig time costs but at a much higher frequency that the typical once a stand survey program. This paper outlines the cost and process savings associated with using the DDS surveys.

Towards a Cognitively Based Quantification of Metrical Dissonance

Metrical dissonance is a powerful tool for creating and manipulating musical tension. The relative extent of tension can be more or less acute depending (in part) on the type of dissonance used and moving among those dissonance types can contribute to the shape of a musical work. This chapter sets out a model for quantifying relative dissonance that incorporates experimentally substantiated principles of cognitive science. A supplementary webpage [**html page] provides an interactive guide for testing out these ideas, and a further online supplement [**URL—included in the main text as Section \ref{sec:online}] provides mathematical formalizations for the principles discussed. We begin with a basic model of metre where a metrical position’s weight is given simply by the number of pulse levels coinciding there. This alone enables a telling categorization of displacement dissonances for simple metres and a first sense of the relative differences between them. These arbitrary weighting ‘values’ are then refined on the basis of tempo and pulse salience. This provides a more subtle set of gradations that reflect the cognitive experience of metre somewhat better while still retaining a clear sense of the simple principles that govern relative dissonance. Additionally, this chapter sees the model applied in a brief, illustrative analysis and in a preliminary extension to ‘mixed’ metres (5s, 7s,…). This sheds light on known problems such as the relative stability of mixed metres in different rotations, and suggests a new way of thinking about mixed metres’ relative susceptibility to metrical dissonance.

Variation in Laboratory Utilization and Correlation with Hospital Bed Utilization: Experience of a Trauma-Care Hospital during the COVID-19 Pandemic

Objectives The present study was planned with the following objectives: (i) to calculate the difference in frequency of laboratory test ordered and use of consumables between the prepandemic and pandemic phases, (ii) to determine and compare the monthly average number of tests ordered per patient between the prepandemic and pandemic phases, and (iii) to correlate the monthly test ordering frequency with the monthly bed occupancy rate in both phases. Materials and Methods Records of laboratory tests ordered and use of consumables were collected for the prepandemic phase (1.8.2019 to 31.3.2020) and the pandemic phase (1.4.2020 to 31.10.2020). The absolute and relative differences were calculated. Monthly average number of tests ordered per patient and bed occupancy rate between prepandemic and pandemic phases was determined, compared, and correlated. Statistical Analysis The absolute and the relative differences between the two periods were calculated. The continuous variables were analyzed between groups using Mann–Whitney U test. Spearman correlation was used to correlate the monthly test ordering frequency with the monthly bed occupancy rate in both phases. Results A total of 946,421 tests were ordered, of which 370,270 (39%) tests were ordered during the pandemic period. There was a decrease in the number of the overall laboratory tests ordered (12%), and in the use of blood collection tubes (34%), and an increase in the consumption of sanitizers (18%), disinfectants (3%), masks (1633%), and gloves (7011%) during the pandemic period. Also, the monthly average number of tests ordered per patients significantly reduced (p-value < 0.001). Test ordering frequency had strong positive correlation with bed occupancy rate during pandemic (Spearman co-efficient = 0.73, p-value = 0.03). Conclusions An overall decline in laboratory utilization during pandemic period was observed. Understanding and correlating the trends with hospital bed utilization can maximize the productivity of the laboratory and help in better preparedness for the challenges imposed during similar exigencies.