Modulation of Presynaptic Transmitter Release by ATP Derived from Postsynaptic Sources

Author(s):  
D. O. Smith ◽  
C. A. Lindgren
Keyword(s):  
Author(s):  
F.T. Llados ◽  
V. Krlho ◽  
G.D. Pappas

It Is known that Ca++ enters the muscle fiber at the junctional area during the action of the neurotransmitter, acetylcholine (ACh). Pappas and Rose demonstrated that following Intense stimulation, calcium deposits are found In the postsynaptic muscle membrane, Indicating the existence of calcium uptake In the postsynaptic area following ACh release. In addition to this calcium uptake, when mammal Ian skeletal muscles are exposed to a sustained action of the neurotransmitter, muscle damage develops. These same effects, l.e., Increased transmitter release, calcium uptake and finally muscle damage, can be obtained by Incubating the muscle with lonophore A23178.


2010 ◽  
Vol 4 (2) ◽  
pp. 86-92 ◽  
Author(s):  
Sunitha Ayers ◽  
Khajak Berberian ◽  
Kevin D. Gillis ◽  
Manfred Lindau ◽  
Bradley A. Minch
Keyword(s):  

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