Abnormal Lipid Metabolism in Primary Nephrotic Syndrome

1987 ◽  
pp. 33-43
Author(s):  
Gaston Zilleruelo ◽  
S. L. Hsia ◽  
Michael Freundlich ◽  
Carolyn Abitbol ◽  
Milan Novak ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Lipid Metabolism ◽  
Primary Nephrotic Syndrome ◽  
Abnormal Lipid Metabolism

Studies on Abnormal Lipid Metabolism in Experimental Nephrotic Syndrome

Nephron ◽  
1993 ◽  
Vol 64 (2) ◽  
pp. 256-261 ◽  
Author(s):  
E.D. Agbedana ◽  
T. Yamamoto ◽  
Y. Moriwaki ◽  
M. Suda ◽  
S. Takahashi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Lipid Metabolism ◽  
Abnormal Lipid Metabolism

STEROID THERAPY EFFICACY FOR PRIMARY NEPHROTIC SYNDROME DEBUT IN CHILDREN

2018 ◽  
Vol 97 (5) ◽  
pp. 61-66
Author(s):  
T.L. Nastausheva ◽  
◽  
O.A. Zhdanova ◽  
G.A. Batishcheva ◽  
Yu.N. Chernov ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Therapy ◽  
Primary Nephrotic Syndrome ◽  
Therapy Efficacy

scholarly journals Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines

2021 ◽  
Author(s):  
Liping Yang ◽  
Yixuan Hou ◽  
Yan-e Du ◽  
Qiao Li ◽  
Fanlin Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lipid Metabolism ◽  
Gastric Cancer Cell ◽  
Cancer Metastasis ◽  
Host Gene ◽  
Diagnostic Biomarker ◽  
Invasion And Metastasis ◽  
Gastric Cancer Cells ◽  
Tumor Progress ◽  
Abnormal Lipid Metabolism

AbstractThe aberrant classical miRNAs are considered to play significant roles in tumor progression. However, it remains unclear for nonclassical miRNAs, a set of Drosha-independent miRNAs in the process of various biology. Here, we reveal that a nonclassical miR-4646-5p plays a pivotal role in gastric cancer (GC) metastasis. MiR-4646-5p, one of Drosha-independent mirtronic miRNA, is aberrant up-regulated in Drosha-low expressed GC and Drosha-knockdown gastric cancer cells. Mirtronic miR-4646-5p is a specific transcription splicing product of intron 3 of the host gene Abhd16a with the aid of SRSF2. The enhanced miR-4646-5p can stabilize HIF1A by targeting PHD3 to positive feedback regulate Abhd16a and miR-4646-5p itself expressions. ABHD16A, as an emerging phosphatidylserine-specific lipase, involves in lipid metabolism leading to lysophosphatidylserines (lyso-PSs) accumulation, which stimulates RhoA and downstream LIMK/cofilin cascade activity through GPR34/Gi subunit, thus causes metastasis of gastric cancer. In addition, miR-4646-5p/PHD3/HIF1A signaling can also up-regulate RhoA expression and synergistically promote gastric cancer cell invasion and metastasis. Our study provides new insights of nonclassical mirtronic miRNA on tumor progress and may serve as a new diagnostic biomarker for gastric cancer. MiR-4646-5p and its host gene Abhd16a mediated abnormal lipid metabolism may be a new target for clinical treatment of gastric cancer.

Sign in / Sign up

Export Citation Format

Share Document