Evaluation of Blood Volume State Using the Quotient of Urine Sodium and Potassium Excretion in Primary Nephrotic Syndrome in Children

The present investigation was designed to determine whether peptides derived from the NH(2)-terminal portion of the 126-amino acid prohormone (pro) of atrial natriuretic factor (ANF) have natriuretic and diuretic properties similar to ANF. Three peptides consisting of amino acids 1-30 [(proANF-(1-30)], 31-67 [proANF-(31-67)], and 79-98 (proANF-(79-98)] of the ANF prohormone were tested and compared with the COOH-terminus peptide (ANF) with respect to their ability to increase urine volume, urine sodium and potassium excretion, and glomerular filtration rate (GFR) in anesthetized Munich-Wistar rats. Each of these peptides except proANF-(79-98) caused a significant diuresis (P less than 0.05) when infused at their respective 100 ng.kg body wt-1.min-1 concentrations for 120 min. ProANFs-(1-30), (31-67), (79-98), and (99-126) (ANF) increased sodium excretion by 231, 973, 167, and 1,405%, respectively. The fractional excretion of sodium compared with control was significant at P less than 0.05, P less than 0.01, and P less than 0.05 for proANFs (1-30), (31-67), and (99-126), respectively. ProANF-(79-98) did not significantly increase the fractional excretion of sodium, but it was the only peptide from the NH(2)-terminus of the prohormone that significantly increased the fractional excretion of potassium's ProANF-(31-67) did not increase urinary potassium excretion. ProANF-(1-30), (79-98), and ANF significantly (P less than 0.05) increased urinary potassium excretion. None of these peptides significantly enhanced GFR. In conclusion, three peptides from the NH(2)-terminus of the ANF prohormone as well as ANF (the COOH-terminus) have either natriuretic, kaliuretic, and/or diuretic properties, but the respective ability of each of these peptides to produce these effects varies considerably.

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Low correlation between morning spot and 24-hour urine samples for estimating sodium intake in an Iranian population: Isfahan Salt Study

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000558 ◽

2019 ◽

Vol 89 (3-4) ◽

pp. 185-191

Author(s):

Alireza Khosravi ◽

Noushin Mohammadifard ◽

Mojagn Gharipour ◽

Zahra Abdollahi ◽

Fatemeh Nouri ◽

...

Keyword(s):

Sodium Excretion ◽

Salt Intake ◽

Iranian Population ◽

Urine Samples ◽

Potassium Excretion ◽

Urine Sodium ◽

Gold Standard Method ◽

Spot Urine ◽

Sodium And Potassium ◽

Tanaka Formula

Abstract. Introduction: Although difficult, the 24-hour urine sodium excretion is still considered as the gold standard method to estimate salt intake. The current study aimed to assess the validity of using spot urine samples in comparison with the standard 24-hour urine collection to estimate sodium and potassium intake in healthy Iranian adults. Methods and subjects: This cross-sectional study was performed on 1099 healthy Iranians aged 18–69 years. Samples of 24-hour and fasting morning spot urine were collected to measure sodium and potassium excretions. Tanaka’s formula was utilized to predict the 24-hour sodium and potassium urinary excretions based on the spot values. Results: The difference between measured and estimated sodium excretion values was 4265 mg/day (95% CI: 4106–4424; P < 0.001) and 2242 mg/day in case of potassium excretion (95% CI: 2140–2344; P < 0.001). There was a weak significant correlation between the 24-hour urine sodium and potassium excretion and the predicted values (intraclass correlations: 0.22 and 0.28, respectively; both P < 0.001). Conclusion: The weak association between the predicted and measured values of sodium and potassium along with the marked overestimation of daily sodium and potassium excretions based on the spot urine and using Tanaka formula indicates that Tanaka formula is not practical for the prediction of sodium and potassium or salt intake in Iranian adults. Using other spot urine sampling times and/or adopting a formula designed based on the characteristics of the Iranian population may increase the validity of spot urine tests.

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Association between 24-hour urine sodium and potassium excretion and diet quality in six-year-old children: a cross sectional study

Nutrition Journal ◽

10.1186/1475-2891-11-94 ◽

2012 ◽

Vol 11 (1) ◽

Cited By ~ 14

Author(s):

Oddny K Kristbjornsdottir ◽

Thorhallur I Halldorsson ◽

Inga Thorsdottir ◽

Ingibjorg Gunnarsdottir

Keyword(s):

Diet Quality ◽

Cross Sectional Study ◽

Potassium Excretion ◽

Sectional Study ◽

Urine Sodium ◽

Cross Sectional ◽

Sodium And Potassium

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Effect of spironolactone on diuresis and urine sodium and potassium excretion in healthy dogs

Journal of Veterinary Cardiology ◽

10.1016/j.jvc.2007.10.002 ◽

2007 ◽

Vol 9 (2) ◽

pp. 63-68 ◽

Cited By ~ 13

Author(s):

E. Jeunesse ◽

F. Woehrle ◽

M. Schneider ◽

H.P. Lefebvre

Keyword(s):

Potassium Excretion ◽

Urine Sodium ◽

Healthy Dogs ◽

Sodium And Potassium

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SP446IS THERE ANY RELATIONSHIP BETWEEN DIABETIC MICROVASCULAR COMPLICATIONS AND DAILY INTAKE OF SODIUM AND POTASSIUM CALCULATED BY URINE SODIUM AND POTASSIUM EXCRETION

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfy104.sp446 ◽

2018 ◽

Vol 33 (suppl_1) ◽

pp. i498-i498

Author(s):

Tolgahan Sevimli ◽

Belgin Sevimli ◽

Murvet Yilmaz ◽

Yildiz Okuturlar ◽

Suheyla Apaydin

Keyword(s):

Microvascular Complications ◽

Daily Intake ◽

Potassium Excretion ◽

Urine Sodium ◽

Diabetic Microvascular Complications ◽

Sodium And Potassium

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Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion

Annals of Laboratory Medicine ◽

10.3343/alm.2015.35.2.238 ◽

2015 ◽

Vol 35 (2) ◽

pp. 238-241 ◽

Cited By ~ 9

Author(s):

Hyunmin Koo ◽

Sang-Guk Lee ◽

Jeong-Ho Kim

Keyword(s):

Urinary Sodium ◽

Potassium Excretion ◽

Urine Sodium ◽

Sodium And Potassium

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Sodium and potassium exchanges in adrenalectomized rats administered deoxycorticosterone chronically

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y70-106 ◽

1970 ◽

Vol 48 (11) ◽

pp. 735-744

Author(s):

Melvin J. Fregly ◽

Ku Ja Kim

Keyword(s):

Body Weight ◽

Control Period ◽

Distilled Water ◽

Potassium Excretion ◽

Nacl Solution ◽

Urine Sodium ◽

Potassium Intake ◽

The Relationship ◽

Sodium And Potassium ◽

Adrenalectomized Rats

Fifteen male adrenalectomized rats were divided into three equal groups and given powdered Purina diet and a choice between 0.30 M NaCl solution and distilled water. Body weight, intakes of food and fluids, urine output, and urine sodium and potassium concentrations were measured daily during a 7-day control period. At this time, two of the groups were administered 250 and 500 μg deoxycorticosterone acetate (DOCA) per kg body weight per day s.c. in oil. Controls received oil. The measurements listed above were taken for an additional 11 days of treatment. All groups ingested more NaCl solution than water during the control period. When DOCA was begun, both sodium output (meq/day) and intake (meq/day) were reduced proportionately and the linear relationship between them observed before treatment was maintained. Under these conditions adrenalectomized rats failed to escape from the sodium-retaining effects of DOCA. Furthermore, both the reduced output and intake of sodium remained for 10 days after drug administration ceased. Although administration of DOCA increased potassium excretion, food intake also increased such that the relationship between potassium intake and output observed before treatment was maintained. The urinary Na/K ratio was reduced significantly during drug treatment. The results suggest that mineralo-corticoid hormones are important in the control of both output and intake of sodium in the rat.

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