Diagnosis of Poorly Differentiated Carcinoma of the Lung

1983 ◽  
pp. 87-108
Author(s):  
John M. Lukeman ◽  
Bruce Mackay
Keyword(s):  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated

scholarly journals Challenging Diagnosis in NUT Carcinoma

2021 ◽  
pp. 106689692110195
Author(s):  
Grosse Claudia ◽  
Grosse Alexandra
Keyword(s):  
Nuclear Protein ◽  
Hematological Malignancy ◽  
Undifferentiated Carcinoma ◽  
Squamous Differentiation ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated ◽  
Nut Carcinoma ◽  
Disseminated Disease ◽  
Generation Sequencing

Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene. The histomorphological appearance ranges from entirely undifferentiated carcinoma to carcinoma with prominent squamous differentiation. NUT carcinoma can display neuroendocrine features. Although it is typically distributed along the midline axis, it may manifest in nonmidline locations. The majority of patients develop rapidly disseminated disease. We illustrate 2 cases of NUT carcinoma, one located in the lung, which closely resembled a neuroendocrine carcinoma, and the other one with assumed lung origin demonstrating metastatic dissemination with diffuse bone involvement, which was clinically first suspected to be a hematological malignancy. Due to its undifferentiated nature, NUT carcinoma may be confused with many entities. NUT immunohistochemistry is considered to be sufficient for the diagnosis. Fluorescence in-situ hybridization analysis and next-generation sequencing are currently used to confirm the diagnosis.

The Thyroid Gland: Recurring Problems in Histologic and Cytologic Evaluation

2008 ◽  
Vol 132 (4) ◽  
pp. 622-632
Author(s):  
William C. Faquin
Keyword(s):  
Thyroid Gland ◽  
Follicular Adenoma ◽  
Endocrine System ◽  
Follicular Carcinoma ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Poorly Differentiated Carcinoma ◽  
Different Types ◽  
Poorly Differentiated ◽  
Common Malignancy

Abstract Nodules of the thyroid gland are frequently encountered, occurring in up to 7% of the population, and although most of these nodules are benign, carcinomas of the thyroid gland are the most common malignancy of the endocrine system. Although the different types of thyroid carcinoma are few, a wide variety of recurring problems exists in both their histologic and cytologic evaluation. Here, I will review a selected group of problematic areas, including unusual histologic variants of follicular adenoma, criteria for diagnosing minimally invasive follicular carcinoma, the use of fine-needle aspiration as a screening test for follicular neoplasia, challenging variants of papillary carcinoma, and features of poorly differentiated carcinoma.

Poorly Differentiated Carcinoma and Anaplastic Carcinoma of the Thyroid

2019 ◽  
pp. 371-384
Author(s):  
Francesca Maletta ◽  
Jasna Metovic ◽  
Marco Volante ◽  
Mauro Papotti
Keyword(s):  
Anaplastic Carcinoma ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated

scholarly journals Highlighting the importance of multidisciplinary approach: A rare case of primary periurethral poorly differentiated carcinoma

2020 ◽  
Vol 59 (1) ◽  
pp. 150-153
Author(s):  
Kallirhoe Kalinderi ◽  
Michail Kalinderis ◽  
Konstantinos Linos ◽  
Georgios Salpigidis ◽  
Evangelos Papanikolaou ◽  
...  
Keyword(s):  
Rare Case ◽  
Multidisciplinary Approach ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated

scholarly journals Mouse Model of Thyroid Cancer Progression and Dedifferentiation Driven by STRN-ALK Expression and Loss of p53: Evidence for the Existence of Two Types of Poorly Differentiated Carcinoma

Thyroid ◽  
2019 ◽  
Vol 29 (10) ◽  
pp. 1425-1437
Author(s):  
Alyaksandr V. Nikitski ◽  
Susan L. Rominski ◽  
Vincenzo Condello ◽  
Cihan Kaya ◽  
Mamta Wankhede ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Mouse Model ◽  
Cancer Progression ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated

scholarly journals Poorly differentiated carcinoma of the thyroid retrospective clinical and morphologic evaluation

1990 ◽  
Vol 5 (1) ◽  
pp. 47 ◽  
Author(s):  
Tae Sook Hwang ◽  
Jin Suk Suh ◽  
Yong Il Kim ◽  
Seong Hoe Park ◽  
Chang Soon Koh ◽  
...  
Keyword(s):  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated

scholarly journals Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour?

2020 ◽  
Vol 8 ◽  
pp. 2050313X2092203
Author(s):  
Susanne Flach ◽  
Aaron SJ Ferguson ◽  
Sharon White ◽  
Paul S White ◽  
Jaiganesh Manickavasagam
Keyword(s):  
Malignant Transformation ◽  
Inverted Papilloma ◽  
High Rate ◽  
Unique Case ◽  
Solitary Lesion ◽  
Poorly Differentiated Carcinoma ◽  
Nasopharyngeal Biopsy ◽  
Poorly Differentiated ◽  
The Right

Inverted papilloma is a rare and benign tumour. It affects the nasal cavity and paranasal sinuses, has a high rate of recurrence and is associated with malignant transformation. Only few cases of a poorly differentiated carcinoma arising from inverted papilloma have been reported, none of which in the nasopharynx. We report a case of a 37-year-old female, who presented originally in 2012 with inverted papilloma of the nasal septum which was surgically resected. Nasopharyngeal biopsy from 2014 was reported as carcinoma in situ and treated with local endoscopic resection. Three years later she presented with a solitary lesion of the right Eustachian tube opening, confirmed as invasive poorly differentiated carcinoma. Imaging revealed T4 N2b M0 malignancy with skull base and prevertebral space invasion, likely extension into right temporal lobe and malignant adenopathy. Although rare, malignant transformation of inverted papilloma in unusual places should be considered during workup and monitoring of patients.

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