Neurohypophyseal Hormones: Old and New Slants on the Relationship of Chemical Structure to Biological Activity

1973 ◽  
pp. 297-313
Author(s):  
Irving L. Schwartz
Keyword(s):  
Biological Activity ◽  
Chemical Structure ◽  
Neurohypophyseal Hormones ◽  
Relationship Of ◽  
The Relationship

scholarly journals Computing Eccentricity Based Topological Indices of Octagonal Grid Omn

Mathematics ◽  
2018 ◽  
Vol 6 (9) ◽  
pp. 153 ◽  
Author(s):  
Xiujun Zhang ◽  
Muhammad Siddiqui ◽  
Muhammad Naeem ◽  
Abdul Baig
Keyword(s):  
Biological Activity ◽  
Chemical Structure ◽  
Acid Hydrazide ◽  
Graph Invariants ◽  
Eccentric Connectivity Index ◽  
Zagreb Index ◽  
Carboxylic Acid Hydrazide ◽  
Relationship Of ◽  
The Relationship ◽  
Connective Index

Graph theory is successfully applied in developing a relationship between chemical structure and biological activity. The relationship of two graph invariants, the eccentric connectivity index and the eccentric Zagreb index are investigated with regard to anti-inflammatory activity, for a dataset consisting of 76 pyrazole carboxylic acid hydrazide analogs. The eccentricity ε v of vertex v in a graph G is the distance between v and the vertex furthermost from v in a graph G. The distance between two vertices is the length of a shortest path between those vertices in a graph G. In this paper, we consider the Octagonal Grid O n m . We compute Connective Eccentric index C ξ ( G ) = ∑ v ∈ V ( G ) d v / ε v , Eccentric Connective Index ξ ( G ) = ∑ v ∈ V ( G ) d v ε v and eccentric Zagreb index of Octagonal Grid O n m , where d v represents the degree of the vertex v in G.

The relationship of chemical structure of urea derivatives to antispasmodic activity

1979 ◽  
Vol 13 (5) ◽  
pp. 497-499
Author(s):  
A. G. Pechenkin ◽  
L. G. Tugnibidina ◽  
V. K. Gorshkova ◽  
L. A. Tikhonova
Keyword(s):  
Chemical Structure ◽  
Antispasmodic Activity ◽  
Urea Derivatives ◽  
Relationship Of ◽  
The Relationship

Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

2019 ◽  
Vol 4 (42) ◽  
pp. 12386-12390
Author(s):  
Armen S. Galstyan ◽  
Tariel V. Ghochikyan ◽  
Melanya A. Samvelyan ◽  
Vardges R. Frangyan ◽  
Muhammad Sarfraz
Keyword(s):  
Biological Activity ◽  
Triazole Derivatives ◽  
Relationship Of ◽  
The Relationship

Structure—activity relationships for in vitro oxime reactivation of chlorpyrifos-inhibited acetylcholinesterase

2007 ◽  
Vol 61 (4) ◽  
Author(s):  
K. Kuča ◽  
V. Račáková ◽  
D. Jun
Keyword(s):  
Biological Activity ◽  
Active Site ◽  
Ache Activity ◽  
Chemical Structure ◽  
Organophosphorus Pesticides ◽  
Ache Inhibitors ◽  
Structure Activity ◽  
The Relationship ◽  
Representative Member

AbstractOrganophosphorus pesticides parathion, chlorpyrifos, and malathion inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of intoxication by these AChE inhibitors. In this work, chlorpyrifos, a representative member of this pesticide family, was used to inhibit the AChE activity of rat brain. The effect of twenty-one structurally different AChE reactivators was tested in vitro and subsequently, the relationship between their chemical structure and biological activity was outlined.

Identification of a reticuloendothelial stimulating agent in zymosan

1961 ◽  
Vol 200 (2) ◽  
pp. 297-300 ◽  
Author(s):  
S. J. Riggi ◽  
N. R. Di Luzio
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Intravenous Injection ◽  
Functional Activity ◽  
Chemical Structure ◽  
Reticuloendothelial System ◽  
Yeast Cell Wall ◽  
Bound Lipids ◽  
Relationship Of ◽  
The Relationship

The functional activity of the reticuloendothelial system (RES), as determined by the intravascular clearance of colloidal carbon, and the degree of induced RE hyperplasia were studied following the intravenous injection of various constituents of zymosan. The readily extractable lipid component from the yeast cell wall was inactive, as was the polysaccharide, mannan. Stimulatory activity was still present in the zymosan residue after removal of free and bound lipids. The administration of glucan derived either from yeast, or its cell wall, resulted in marked RE activation and induced hyperplasia, demonstrating it to be the active RE stimulating agent. The relationship of glucan's chemical structure to its ability to induce RE hyperfunction and hyperplasia is discussed.

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