Amyloid-β Precursor Protein Induces Glial Differentiation of Neural Progenitor Cells by Activation of the IL-6/gp130 Signaling Pathway

2010 ◽  
pp. 131-141
Author(s):  
Young-Don Kwak ◽  
Elise Dantuma ◽  
Stephanie Merchant ◽  
Sergey Bushnev ◽  
Kiminobu Sugaya
Keyword(s):  
Progenitor Cells ◽  
Signaling Pathway ◽  
Neural Progenitor Cells ◽  
Amyloid Β ◽  
Neural Progenitor ◽  
Precursor Protein ◽  
Glial Differentiation

Amyloid-β Precursor Protein Induces Glial Differentiation of Neural Progenitor Cells by Activation of the IL-6/gp130 Signaling Pathway

2010 ◽  
Vol 18 (3-4) ◽  
pp. 328-338 ◽  
Author(s):  
Young-Don Kwak ◽  
Elise Dantuma ◽  
Stephanie Merchant ◽  
Sergey Bushnev ◽  
Kiminobu Sugaya
Keyword(s):  
Progenitor Cells ◽  
Signaling Pathway ◽  
Neural Progenitor Cells ◽  
Amyloid Β ◽  
Neural Progenitor ◽  
Precursor Protein ◽  
Glial Differentiation

scholarly journals Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice

Neuroscience ◽  
2014 ◽  
Vol 261 ◽  
pp. 52-59 ◽  
Author(s):  
S. Kanemoto ◽  
J. Griffin ◽  
K. Markham-Coultes ◽  
I. Aubert ◽  
A. Tandon ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Amyloid Β ◽  
Neural Progenitor ◽  
Tgcrnd8 Mice

Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells

Hippocampus ◽  
2011 ◽  
Vol 22 (7) ◽  
pp. 1517-1527 ◽  
Author(s):  
Sara Baratchi ◽  
Jane Evans ◽  
Warren P. Tate ◽  
Wickliffe C. Abraham ◽  
Bronwen Connor
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Amyloid Precursor Proteins ◽  
Glial Differentiation ◽  
Precursor Proteins

Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells

Epigenomics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1143-1161 ◽  
Author(s):  
Deepika Kandilya ◽  
Silambarasan Maskomani ◽  
Sukanya Shyamasundar ◽  
Paul Anantharajah Tambyah ◽  
Chan Shiao Yng ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Zika Virus ◽  
Neural Progenitor Cells ◽  
Methylation Status ◽  
Neural Progenitor ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Human Neural Progenitor Cells

Aim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly.

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