Golgi Cells

2003 ◽  
pp. 45-49
Author(s):  
Orlando J. Castejón
Keyword(s):  
Golgi Cells

scholarly journals Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Angela K Nietz ◽  
Jada H Vaden ◽  
Luke T Coddington ◽  
Linda Overstreet-Wadiche ◽  
Jacques I Wadiche
Keyword(s):  
Feedback Inhibition ◽  
Mossy Fiber ◽  
Molecular Layer ◽  
Cell Activity ◽  
Climbing Fiber ◽  
Climbing Fibers ◽  
In Vivo Studies ◽  
Golgi Cell ◽  
Golgi Cells ◽  
Fiber Stimulation

Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by climbing fiber stimulation, yet there is little functional or anatomical evidence for synapses between climbing fibers and Golgi cells. Here, we show that glutamate released from climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-mediated transmission. The interplay of excitatory and inhibitory conductances provides flexible control over Golgi cell spiking, allowing either excitation or a biphasic sequence of excitation and inhibition following single climbing fiber stimulation. Together with prior studies of spillover transmission to molecular layer interneurons, these results reveal that climbing fibers exert control over inhibition at both the input and output layers of the cerebellar cortex.

Exploiting multi-core and many-core architectures for efficient simulation of biologically realistic models of Golgi cells

2019 ◽  
Vol 126 ◽  
pp. 48-66
Author(s):  
Giordana Florimbi ◽  
Emanuele Torti ◽  
Stefano Masoli ◽  
Egidio D’Angelo ◽  
Giovanni Danese ◽  
...  
Keyword(s):  
Golgi Cells ◽  
Efficient Simulation ◽  
Many Core

Golgi cells, granule cells and synaptic glomeruli in the molecular layer of the rabbit cerebellar cortex

1973 ◽  
Vol 2 (4) ◽  
pp. 407-428 ◽  
Author(s):  
J. Spačer ◽  
J. Pařízek ◽  
A. R. Lieberman
Keyword(s):  
Cerebellar Cortex ◽  
Granule Cells ◽  
Molecular Layer ◽  
Golgi Cells

scholarly journals Heterosynaptic GABAergic plasticity bidirectionally driven by the activity of pre- and postsynaptic NMDA receptors

2016 ◽  
Vol 113 (35) ◽  
pp. 9898-9903 ◽  
Author(s):  
Jonathan Mapelli ◽  
Daniela Gandolfi ◽  
Antonietta Vilella ◽  
Michele Zoli ◽  
Albertino Bigiani
Keyword(s):  
Nmda Receptor ◽  
Granule Cells ◽  
Dynamic Control ◽  
Long Term Potentiation ◽  
Receptor Activation ◽  
Network Activity ◽  
Inhibitory Synapses ◽  
Golgi Cells ◽  
Neural Information

Dynamic changes of the strength of inhibitory synapses play a crucial role in processing neural information and in balancing network activity. Here, we report that the efficacy of GABAergic connections between Golgi cells and granule cells in the cerebellum is persistently altered by the activity of glutamatergic synapses. This form of plasticity is heterosynaptic and is expressed as an increase (long-term potentiation, LTPGABA) or a decrease (long-term depression, LTDGABA) of neurotransmitter release. LTPGABA is induced by postsynaptic NMDA receptor activation, leading to calcium increase and retrograde diffusion of nitric oxide, whereas LTDGABA depends on presynaptic NMDA receptor opening. The sign of plasticity is determined by the activation state of target granule and Golgi cells during the induction processes. By controlling the timing of spikes emitted by granule cells, this form of bidirectional plasticity provides a dynamic control of the granular layer encoding capacity.

scholarly journals Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine

2009 ◽  
Vol 55 (8) ◽  
pp. 775-782 ◽  
Author(s):  
W. Michael Bullock ◽  
Federico Bolognani ◽  
Paolo Botta ◽  
C. Fernando Valenzuela ◽  
Nora I. Perrone-Bizzozero
Keyword(s):  
Gene Expression ◽  
Low Dose ◽  
Golgi Cells

scholarly journals Dynamics of Fast and Slow Inhibition from Cerebellar Golgi Cells Allow Flexible Control of Synaptic Integration

Neuron ◽  
2009 ◽  
Vol 63 (6) ◽  
pp. 843-853 ◽  
Author(s):  
John J. Crowley ◽  
Diasynou Fioravante ◽  
Wade G. Regehr
Keyword(s):  
Synaptic Integration ◽  
Golgi Cells ◽  
Flexible Control

scholarly journals Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent sensory inputs

2006 ◽  
Vol 574 (2) ◽  
pp. 491-507 ◽  
Author(s):  
Tahl Holtzman ◽  
Thimali Rajapaksa ◽  
Abteen Mostofi ◽  
Steve A. Edgley
Keyword(s):  
Purkinje Cells ◽  
Golgi Cells ◽  
Sensory Inputs ◽  
Cerebellar Purkinje Cells
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