Genetics of Osteoporosis

2002 ◽  
pp. 31-42
Author(s):  
Luigi Gennari ◽  
Lucia Becherini ◽  
Alberto Falchetti ◽  
Laura Masi ◽  
Maria Luisa Brandi
Keyword(s):  
Genetics Of Osteoporosis

scholarly journals Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Basel M. Al-Barghouthi ◽  
Larry D. Mesner ◽  
Gina M. Calabrese ◽  
Daniel Brooks ◽  
Steven M. Tommasini ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Strength ◽  
Human Genetics ◽  
Association Studies ◽  
Systems Genetics ◽  
Genome Wide Association Studies ◽  
Mineral Density ◽  
Diversity Outbred ◽  
Wide Range ◽  
Genetics Of Osteoporosis

AbstractGenome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we use Diversity Outbred (DO) mice to directly address these limitations by performing a systems genetics analysis of 55 complex skeletal phenotypes. We apply a network approach to cortical bone RNA-seq data to discover 66 genes likely to be causal for human BMD GWAS associations, including the genes SERTAD4 and GLT8D2. We also perform GWAS in the DO for a wide-range of bone traits and identify Qsox1 as a gene influencing cortical bone accrual and bone strength. In this work, we advance our understanding of the genetics of osteoporosis and highlight the ability of the mouse to inform human genetics.

Genetics of Osteoporosis

1997 ◽  
pp. 126-144 ◽  
Author(s):  
P.J. Kelly ◽  
P.N. Sambrook ◽  
N.A. Morrison ◽  
T. Nguyen ◽  
J.A. Eisman
Keyword(s):  
Genetics Of Osteoporosis

Defining the Genetics of Osteoporosis: Using the Mouse to Understand Man

2001 ◽  
Vol 12 (10) ◽  
pp. 803-810 ◽  
Author(s):  
C. J. Rosen ◽  
W. G. Beamer ◽  
L. R. Donahue
Keyword(s):  
Genetics Of Osteoporosis

Defining the Genetics of Osteoporosis

2002 ◽  
pp. 1657-1665
Author(s):  
C.J. Rosen ◽  
L.R. Donahue ◽  
W.G. Beamer
Keyword(s):  
Genetics Of Osteoporosis

Genetics of osteoporosis

2014 ◽  
Vol 452 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Tomohiko Urano ◽  
Satoshi Inoue
Keyword(s):  
Genetics Of Osteoporosis

Unveiling the mysteries of the genetics of osteoporosis

2014 ◽  
Vol 37 (10) ◽  
pp. 925-934 ◽  
Author(s):  
N. Alonso ◽  
S. H. Ralston
Keyword(s):  
Genetics Of Osteoporosis

scholarly journals Genetics of Osteoporosis

1999 ◽  
Vol 20 (6) ◽  
pp. 788-804 ◽  
Author(s):  
John A. Eisman
Keyword(s):  
Genetics Of Osteoporosis
Sign in / Sign up

Export Citation Format

Share Document