Advances in Cytomegalovirus Diagnostic Testing and Their Implications for Management of Cytomegalovirus Infec tion in Transplant Recipients

Author(s):  
Paolo Grossi
2016 ◽  
Vol 54 (5) ◽  
pp. 1223-1227 ◽  
Author(s):  
Ruth Hall Sedlak ◽  
Joshua A. Hill ◽  
Thuy Nguyen ◽  
Michelle Cho ◽  
Greg Levin ◽  
...  

The presence of inherited chromosomally integrated human herpesvirus 6 (ciHHV-6) in hematopoietic cell transplant (HCT) donors or recipients confounds molecular testing for HHV-6 reactivation, which occurs in 30 to 50% of transplants. Here we describe a multiplex droplet digital PCR clinical diagnostic assay that concurrently distinguishes between HHV-6 species (A or B) and identifies inherited ciHHV-6. By applying this assay to recipient post-HCT plasma and serum samples, we demonstrated reactivation of HHV-6B in 25% (4/16 recipients) of HCT recipients with donor- or recipient-derived inherited ciHHV-6A, underscoring the need for diagnostic testing for HHV-6 infection even in the presence of ciHHV-6.


2011 ◽  
Vol 21 (3) ◽  
pp. 89-99
Author(s):  
Michael F. Vaezi

Gastroesophageal reflux disease (GERD) is a commonly diagnosed condition often associated with the typical symptoms of heartburn and regurgitation, although it may present with atypical symptoms such as chest pain, hoarseness, chronic cough, and asthma. In most cases, the patient's reduced quality of life drives clinical care and diagnostic testing. Because of its widespread impact on voice and swallowing function as well as its social implications, it is important that speech-language pathologists (SLPs) understand the nature of GERD and its consequences. The purpose of this article is to summarize the nature of GERD and GERD-related complications such as GERD-related peptic stricture, Barrett's esophagus and adenocarcinoma, and laryngeal manifestations of GERD from a gastroenterologist's perspective. It is critical that SLPs who work with a multidisciplinary team understand terminology, diagnostic tools, and treatment to ensure best practice.


2001 ◽  
Vol 120 (5) ◽  
pp. A92-A92
Author(s):  
A HABIB ◽  
B BACON ◽  
A BEFELER ◽  
S RAMRAKHIANI ◽  
S RAMRAKHIANI

2001 ◽  
Vol 120 (5) ◽  
pp. A562-A562
Author(s):  
A HABIB ◽  
B BACON ◽  
S RAMRAKHIANI

2001 ◽  
Vol 120 (5) ◽  
pp. A562-A562
Author(s):  
R ROMERO ◽  
K MELDE ◽  
T PILLEN ◽  
G SMALLWOOD ◽  
C ONEILL ◽  
...  

2005 ◽  
Vol 173 (4S) ◽  
pp. 441-442
Author(s):  
Peter C. Fisher ◽  
Jeffrey S. Montgomery ◽  
Willam K. Johnston ◽  
J. Stuart Wolf

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