A Role for Medium-Chain Fatty Acids in the Regulation of Lipid Synthesis in Milk Stasis?

The effects of a series of medium-chain fatty acids (C6-C12) on glucose metabolism in isolated acini from lactating rat mammary glands have been studied. Hexanoate (C6) octanoate (C8) and decanoate (C10), but not laurate (C12), decreased [1-14C]glucose conversion into [14C]lipid and the production of 14CO2 (an index of the pentose phosphate pathway). With hexanoate and octanoate, glucose utilization was decreased, whereas decanoate had a slight stimulatory effect on glucose utilization, but there was a large accumulation of lactate. Addition of dichloroacetate (an inhibitor of pyruvate dehydrogenase kinase) decreased this accumulation of lactate and stimulated the conversion of [1-14C]glucose into [14C]lipid and 14CO2. Insulin had no effect on the rate of glucose utilization in the presence of hexanoate. It stimulated the rate in the presence of octanoate and laurate and increased the conversion of [1-14C]glucose into [14C]lipid in the presence of octanoate, decanoate or laurate. The major fate of 1-14C-labelled medium-chain fatty acids (C6, C8 and C12) was conversion into [14C]lipid. The proportion converted into 14CO2 decreased with increasing chain length, whereas the rate of [14C]lipid formation increased. It is concluded that the interactions between medium-chain fatty acids and glucose metabolism represent a feed-back mechanism to control milk lipid synthesis, and this may be important when milk accumulates in the gland.

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Acyl CoA profiles of transgenic plants that accumulate medium-chain fatty acids indicate inefficient storage lipid synthesis in developing oilseeds

The Plant Journal ◽

10.1046/j.1365-313x.2002.01440.x ◽

2002 ◽

Vol 32 (4) ◽

pp. 519-527 ◽

Cited By ~ 56

Author(s):

Tony R. Larson ◽

Teresa Edgell ◽

James Byrne ◽

Katayoon Dehesh ◽

Ian A. Graham

Keyword(s):

Fatty Acids ◽

Transgenic Plants ◽

Lipid Synthesis ◽

Medium Chain ◽

Medium Chain Fatty Acids ◽

Storage Lipid ◽

Chain Fatty Acids

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Enhanced Bioavailability of Curcumin Nanoemulsions Stabilized with Phosphatidylcholine Modified with Medium Chain Fatty Acids

Current Drug Delivery ◽

10.2174/1567201813666160919142811 ◽

2017 ◽

Vol 14 (3) ◽

pp. 377-385 ◽

Cited By ~ 8

Author(s):

Angelica A. Ochoa-Flores ◽

Josafat A. Hernández-Becerra ◽

Adriana Cavazos-Garduño ◽

Ida Soto-Rodríguez ◽

Maria Guadalupe Sanchez-Otero ◽

...

Keyword(s):

Fatty Acids ◽

Medium Chain ◽

Medium Chain Fatty Acids ◽

Chain Fatty Acids

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Effects of ketogenic diet containing medium-chain fatty acids on serum inflammatory factor and mTOR signaling pathway in rats

Chemical and Biological Technologies in Agriculture ◽

10.1186/s40538-020-00194-4 ◽

2020 ◽

Vol 7 (1) ◽

Author(s):

Huan Liu ◽

Jingwei Huang ◽

Hui Liu ◽

Feng Li ◽

Quansheng Peng ◽

...

Keyword(s):

Fatty Acids ◽

Caloric Restriction ◽

Ketogenic Diet ◽

Mtor Pathway ◽

Inflammatory Factor ◽

Medium Chain ◽

Medium Chain Fatty Acids ◽

Sd Rats ◽

Anti Inflammatory ◽

Chain Fatty Acids

Abstract Background The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats. Results Male SD rats were assigned to five groups: control diet (C), 20% caloric restriction diet (LC), 20% caloric restriction ketogenic diet (containing MCFAs) (LCKD1), 20% caloric restriction ketogenic diet (LCKD2) and 20% caloric restriction foreign ketogenic diet (LCKD3), and fed for 30 d. LC and KD could significantly reduce the body weight of rats; LC and KD containing MCFAs showed anti-inflammatory effects; KD without MCFAs decreased the concentration of mTOR1, while KD containing MCFAs decreased the expression of AMPK, mtor1 and P70sk. Conclusions KD containing MCFAs showed better effects on the mTOR pathway and anti-inflammation than that without MCFAs.

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