Comparison of Technetium-99m-Labelled Human Polyclonal Immunoglobulin Scintigraphy with Conventional Bone Scintigraphy in Patients with Rheumatoid Arthritis and Osteoarthritis

A retrospective analysis of bone scans of 381 children with unexplained skeletal pain was made. Of these, findings are reported on 358 for whom there were sufficient clinical data. The bone scan results suggested trauma as the cause of pain in 43 patients, inflammatory disease in 73 patients, and neoplasia in ten patients. There was only one false-positive bone scan. Normal findings were obtained from 227 patients, in whom no significant skeletal disease was detected on follow-up, except for juvenile rheumatoid arthritis in 23 patients. Bone scintigraphy is, therefore, an important, noninvasive diagnostic test for evaluating children with obscure bone or joint pain. We recommend that this test be performed early in the evaluation of these children to arrive at the diagnosis expeditiously and with minimal patient discomfort and morbidity.

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Scintigraphic evaluation of synovial inflammation in rheumatoid arthritis with 99m technetium-labelled human polyclonal immunoglobulin G

Rheumatology International ◽

10.1007/s002960000081 ◽

2001 ◽

Vol 20 (2) ◽

pp. 71-77 ◽

Cited By ~ 12

Author(s):

Abdullah Cindaş ◽

Yeşim Gökçe-Kutsal ◽

Pınar Özgen Kırtlı ◽

Biray Caner

Keyword(s):

Rheumatoid Arthritis ◽

Immunoglobulin G ◽

Synovial Inflammation ◽

Polyclonal Immunoglobulin

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The Role of Bone Scintigraphy in the Diagnosis of Rheumatoid Arthritis According to the 2010 ACR/EULAR Classification Criteria

Journal of Korean Medical Science ◽

10.3346/jkms.2014.29.2.204 ◽

2014 ◽

Vol 29 (2) ◽

pp. 204 ◽

Cited By ~ 6

Author(s):

Ji Young Kim ◽

Soo-Kyung Cho ◽

Minkyung Han ◽

Yun Young Choi ◽

Sang-Cheol Bae ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Bone Scintigraphy ◽

Classification Criteria

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Comparison of Bone Scintigraphy and PET/CT for the Evaluation of Disease Activity in Patients with Rheumatoid Arthritis: Application of Bone Scintigraphy

10.21203/rs.3.rs-138444/v1 ◽

2021 ◽

Author(s):

Sang Jin Lee ◽

Chae Moon Hong ◽

Il Cho ◽

Byeong-Cheol Ahn ◽

Jung Su Eun ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Bone Scintigraphy ◽

Clinical Assessment ◽

Tender Joint ◽

Positron Emission ◽

Pet Ct ◽

Active Arthritis ◽

Development Group ◽

Joint Assessment

Abstract Background: We aimed to compare the reliability of bone scintigraphy (BS) and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)–derived parameters in the detection of active arthritis in 28-joint areas and evaluate the reliability of joint counts between BS and clinical assessment in patients with rheumatoid arthritis (RA). Methods: We enrolled 106 patients (67 in the development group and 39 in the validation groups) with active RA who underwent BS, 18F-FDG PET/computed tomography (CT), and clinical evaluation of disease activity. We compared the results of BS-derived joint assessment with those of PET-derived and clinical joint assessments. Subsequently we developed a disease activity score (DAS) using BS-positive joints and validated it in an independent group.Results: The number of BS-positive joints in 28-joint areas significantly correlated with the swollen /tender joint counts (SJC/TJC) and PET-derived joint counts. A BS uptake score of 2 (strong positive) was significantly more sensitive compared with a BS uptake score of 1 (weak positive) in detecting a PET-positive joint among the 28-joints. After conducting multivariate analyses including erythrocyte sediment rate (ESR) and patient global assessment (PGA) in addition to BS-derived parameters, BS/DAS was obtained as follows: 0.056 × number of BS-positive joints in 28 joints + 0.012 × ESR + 0.030 × PGA. A significant correlation between BS/DAS and DAS28-ESR was confirmed in the validation group. Conclusion: Strong positive uptake of BS is sensitive and reproducible for the detection of active joints, and can complement the clinical assessment of disease activity in RA.

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