Scintigraphic evaluation of synovial inflammation in rheumatoid arthritis with 99m technetium-labelled human polyclonal immunoglobulin G

2001 ◽  
Vol 20 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Abdullah Cindaş ◽  
Yeşim Gökçe-Kutsal ◽  
Pınar Özgen Kırtlı ◽  
Biray Caner
Keyword(s):  
Rheumatoid Arthritis ◽  
Immunoglobulin G ◽  
Synovial Inflammation ◽  
Polyclonal Immunoglobulin

Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G

1991 ◽  
Vol 18 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Peter A. H. M. van der Lubbe ◽  
Jan W. Arndt ◽  
Wim Calame ◽  
Teresa C. Ferreira ◽  
Ernest K. J. Pauweis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immunoglobulin G ◽  
Synovial Inflammation ◽  
Technetium 99M ◽  
Polyclonal Immunoglobulin

Amidase and Peptidase Activities of Polyclonal Immunoglobulin G Present in the Sera of Patients with Rheumatoid Arthritis

2000 ◽  
Vol 83 (1-3) ◽  
pp. 107-114 ◽  
Author(s):  
kinji Matsuura ◽  
Shinya Ikoma ◽  
Masafumi Sugiyama ◽  
Masanori Funauchi ◽  
Hyogo Sinohara
Keyword(s):  
Rheumatoid Arthritis ◽  
Immunoglobulin G ◽  
Polyclonal Immunoglobulin

scholarly journals Purification of rabbit polyclonal immunoglobulin G using anion exchangers

2011 ◽  
Vol 46 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Rattana Wongchuphan ◽  
Beng Ti Tey ◽  
Wen Siang Tan ◽  
Senthil Kumar Subramanian ◽  
Farah Saleena Taip ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Anion Exchangers ◽  
Polyclonal Immunoglobulin

scholarly journals Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhongde Ye ◽  
Yi Shen ◽  
Ke Jin ◽  
Jingtao Qiu ◽  
Bin Hu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Arachidonic Acid ◽  
Lupus Erythematosus ◽  
Calcium Influx ◽  
Cell Receptor ◽  
Synovial Inflammation ◽  
Chimeric Mouse ◽  
T Cell Receptor Signaling ◽  
Chimeric Mouse Model

AbstractRheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show that CD4+ T cells from patients with RA and PsA have increased expression of the pore-forming calcium channel component ORAI3, thereby increasing the activity of the arachidonic acid-regulated calcium-selective (ARC) channel and making T cells sensitive to arachidonic acid. A similar increase does not occur in T cells from patients with systemic lupus erythematosus. Increased ORAI3 transcription in RA and PsA T cells is caused by reduced IKAROS expression, a transcriptional repressor of the ORAI3 promoter. Stimulation of the ARC channel with arachidonic acid induces not only a calcium influx, but also the phosphorylation of components of the T cell receptor signaling cascade. In a human synovium chimeric mouse model, silencing ORAI3 expression in adoptively transferred T cells from patients with RA attenuates tissue inflammation, while adoptive transfer of T cells from healthy individuals with reduced expression of IKAROS induces synovitis. We propose that increased ARC activity due to reduced IKAROS expression makes T cells more responsive and contributes to chronic inflammation in RA and PsA.

Detection of inflammation/infection with human polyclonal immunoglobulin G labelled with99Tcm

1994 ◽  
Vol 67 (800) ◽  
pp. 770-774 ◽  
Author(s):  
A Jiménez-Heffernan ◽  
J L Villanueva ◽  
A Moral ◽  
A Rebollo ◽  
F M González ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Polyclonal Immunoglobulin

scholarly journals Monoclonal and polyclonal immunoglobulin G deposits on tubular basement membranes of native and pretransplant kidneys: A retrospective study

2020 ◽  
Author(s):  
Anri Sawada ◽  
Masayoshi Okumi ◽  
Shigeru Horita ◽  
Tomomi Tamura ◽  
Sekiko Taneda ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Immunoglobulin G ◽  
Basement Membranes ◽  
Polyclonal Immunoglobulin

Abstract The authors have withdrawn this preprint due to author disagreement.

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